Preparation method of ropivacaine hydrochloride
A technology of ropivacaine hydrochloride, volume, applied in the field of chemistry, to achieve the effect of simple steps, high purity and high recovery rate
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0020] A kind of preparation method of ropivacaine hydrochloride is characterized in that, comprises the steps:
[0021] (1) Preparation of intermediate (I): 10 parts by weight of 2-piperidinecarboxylic acid and 120 parts by volume of toluene and chloroform mixture with a volume ratio of 2:1 are added to the conical flask, stirred evenly, and HCl gas is introduced to pH2 ; Erlenmeyer flask is placed in ultrasonic instrument (ultrasonic instrument power is set to 300W), add the N,N-dimethylformamide of 1.5 parts by volume, drop the toluene of thionyl chloride of 13 parts by weight and 20 parts by volume Mixed solution, after dropping, ultrasonic at 40°C for 1.5h, nitrogen gas for 1.5h; dropwise add 20 weight parts of 2,6-dimethylaniline and 30 volume parts of toluene mixture, 45°C for 1.2h, filter to obtain brown wet product, dried to obtain a gray solid, the solid was added to 240 parts by volume of purified water, and stirred to obtain a reaction solution; 10% NaOH solution w...
Embodiment 2
[0026] A kind of preparation method of ropivacaine hydrochloride is characterized in that, comprises the steps:
[0027] (1) Preparation of intermediate (I): 12 parts by weight of 2-piperidinecarboxylic acid and 160 parts by volume of toluene and chloroform mixture with a volume ratio of 2:1 are added to the conical flask, stirred evenly, and HCl gas is introduced to pH3 ; Erlenmeyer flask is placed in ultrasonic instrument (ultrasonic instrument power is set to 300W), add the N,N-dimethylformamide of 1.6 parts by volume, drop the toluene of thionyl chloride of 14 parts by weight and 20 parts by volume Mixed solution, after dropping, ultrasonic at 45°C for 1h, nitrogen gas for 2h; dropwise add 25 parts by weight of 2,6-dimethylaniline and 40 parts by volume of toluene, ultrasonically at 50°C for 1h, filter to obtain a brown wet product, bake Dry to obtain a gray solid, add the solid to 300 parts by volume of purified water, and stir to dissolve to obtain a reaction solution; a...
Embodiment 3
[0032] The difference between this example and Example 1 is that the volume ratio of toluene to chloroform is 1:1 to obtain ropivacaine hydrochloride fine-quality sample 3. The purity is as high as 99.5%; the recovery rate is 86%;
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com