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Nigaichigosides F1 dressing for promoting scarless wound healing and preparation method thereof

A technology of wound healing and ichorberry, which is applied in the field of ichorberry F1 dressing and preparation, to achieve the effects of convenient operation, inhibition of inflammation, and promotion of wound healing

Inactive Publication Date: 2017-10-20
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no other public disclosure about the effect of acheberry glycoside F1 on promoting wound healing and reducing scar formation

Method used

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  • Nigaichigosides F1 dressing for promoting scarless wound healing and preparation method thereof
  • Nigaichigosides F1 dressing for promoting scarless wound healing and preparation method thereof
  • Nigaichigosides F1 dressing for promoting scarless wound healing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: Preparation of acroticin F1 / zein / chitosan dressing

[0035] 99g zein (22-24kDa, Sigma-Aldrich) and 1g chitosan (50-190kDa, 75% deacetylation, Sigma-Aldrich) were dissolved in 300mL aqueous solution containing 70% ethanol and 2% acetic acid, the Add 20mg of aiciticin F1 to the above alkyd solution to obtain aicicticin F1 complex solution. At 25°C and 60% humidity, the spinning solution was placed in a syringe, the spinning speed was set at 0.2mL / h by a micro-syringe pump (KDS250, KD Scientific), and the electrostatic voltage was controlled at 14kV (high-voltage electrostatic emitter, HB -Z503-1AC, Tianjin Hengbo High Voltage Power Supply Factory), the receiving distance was 10cm, and the nanofiber membrane was prepared. Put the nanofibrous membrane in a vacuum drying oven (DZF-1B, Shanghai Yuejin Medical Instrument Factory), set the temperature at 45°C, and vacuum at 0.08MPa, and dry it for 12h to obtain the acheberryin F1 / zein / chitosan Sugar dressing.

Embodiment 2

[0036] Embodiment 2: the application of the dressing of afraiculin F1 / zein / chitosan prepared in embodiment 1

[0037] After adapting New Zealand white rabbits weighing 1.5-2.5 kg for 1 week, the back hair of the rabbits was removed with 8% sodium sulfide (analytical grade, Changzhou Shengfeng Chemical Reagent Co., Ltd.) solution. After 24 hours, 70% ethanol was used to disinfect the skin preparation area, and 0.5% lidocaine injection (medical grade, Wanrong Sanjiu Pharmaceutical Co., Ltd.) was anesthetized by subcutaneous injection at a dose of 60 mg / kg. Using surgical scissors and forceps, cut off three full-thickness layers of skin with a diameter of 1 cm on both sides of the midline on the back of each rabbit.

[0038] Experimental animals were divided into 3 groups, 3 animals in each group: alopein F1 / zein / chitosan dressing (NCC) group, zein / chitosan (CC) dressing group, ethacridine ( Dalian Shuangdao Pharmaceutical Factory) control group. Wherein, the zein / chitosan (CC)...

Embodiment 3

[0041] Example 3: Preparation and application of acroticin F1 / zein / hyaluronic acid dressing

[0042] 95g zein (22-24kDa, Sigma-Aldrich) and 5g sodium hyaluronate (95%, Sigma-Aldrich) were dissolved in 300mL of aqueous solution containing 30% ethanol and 30% acetic acid, and 5mg of acheberryin F1 was added into the above-mentioned alkyd solution to obtain a complex solution of aicartin F1. At 25°C and 60% humidity, the spinning solution was placed in a syringe, the spinning speed was set at 0.1mL / h by a micro syringe pump (KDS250, KD Scientific), and the electrostatic voltage was controlled at 14kV (high voltage electrostatic emitter, HB -Z503-1AC, Tianjin Hengbo High Voltage Power Supply Factory), the receiving distance was 10cm, and the nanofiber membrane was prepared. Put the nanofibrous membrane in a vacuum drying oven (DZF-1B, Shanghai Yuejin Medical Instrument Factory), set the temperature at 55°C, and vacuum at 0.1MPa, and dry it for 12h to obtain Afrabysin F1 / zein / hyal...

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Abstract

The invention discloses a nigaichigosides F1 dressing for promoting scarless wound healing and a preparation method thereof, and belongs to the technical field of biomedical materials. It is proved that nigaichigosides F1 has the function of promoting wound healing and reducing scar formation. Meanwhile, the nigaichigosides F1 dressing for promoting wound healing and reducing scar formation is prepared by electrospinning. The nigaichigosides F1 dressing is a composite fiber membrane comprising the nigaichigosides F1 and zein, wheat gliadin, chitosan, hyaluronic acid or cellulose. he nigaichigosides F1 dressing is prepared by collection of affinity and moisturizing characteristics of a new wet dressing and the effect characteristics of promoting wound healing and reducing scar formation of the nigaichigosides F1, and has great medical application value for treatment of burns, incise injury, ulcers, pressure sores and other wounds.

Description

technical field [0001] The invention relates to an acheberry glycoside F1 dressing for promoting wound healing without scar and a preparation method thereof, belonging to the technical field of biomedical materials. Background technique [0002] The skin is the most important barrier organ of the human body. Due to trauma, ulcers, burns, etc., it may cause acute or chronic extensive damage to the skin, affecting various functions of the skin including barrier protection, absorption metabolism, secretion and excretion, temperature regulation, and immunity, and may lead to complications. life threatening. The fibers of traditional dressings (gauze / gauze) have poor absorption of exudate, and it is easy to cause wound re-injury when replaced, prolonging the wound healing time. At present, a large number of new micro-nano materials with high biocompatibility have emerged, such as silver ion dressings, calcium sodium alginate dressings, hydrogels, foam dressings and other wet dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61K31/704A61P17/02
CPCA61L15/44A61K31/704A61L15/28A61L15/32A61L2300/232A61L2300/412C08L89/00C08L5/08
Inventor 成向荣夏淑芳孙进唐雪乐国伟
Owner JIANGNAN UNIV
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