New application of gp73 and a detection kit for liver tissue inflammation activity based on it
A liver tissue and kit technology, which is applied in the field of biomedicine to achieve high-efficiency treatment effects, high-efficiency diagnosis, and rapid wound recovery.
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Embodiment 1
[0043] Embodiment 1 experimental design
[0044] 1.1 Research object
[0045] From December 2013 to December 2016, 642 patients with chronic liver disease underwent B-ultrasound-guided liver puncture in Beijing 302 Hospital.
[0046] 1.2 Statistical methods
[0047] The SPSS21.0 (SPSS, Chicago, Illinois, USA) statistical software was used for statistical analysis, the continuous variable was selected according to its distribution characteristics, and the quantitative data approximately obeying the normal distribution was used x ±S means that the median (M) and interquartile range are used to describe the distribution characteristics of the quantitative data showing a skewed distribution, the χ2 test is used for the comparison between qualitative data groups, and the Mann-WhitnyU test is used for the comparison between two independent samples. The Kruskal-Wallis test was used between samples. Receiver operating characteristic curve (ROC curve) was established, and the eval...
Embodiment 2
[0054] Embodiment 2 test result analysis
[0055] 2.1 Expression levels of serum GP73, ALT, AST in different degrees of liver tissue inflammation activity
[0056] The change trend of serum GP73, ALT and AST in different degrees of liver tissue inflammation activity was described by interquartile range. The levels of serum GP73 in different degrees of liver tissue inflammation activity were G0-1 (n=241): 41.43 (24.34-58.08) ng / mL; G2 (n=239): 69.26 (45.66-115.38) ng / mL; G3 / 4 (n=46): 122.54 (72.19-186.51) ng / mL; Spearman correlation analysis showed that serum GP73 was significantly correlated with liver tissue inflammation activity (Spearman correlation coefficient r=0.609, Pfigure 1 and Table 3 below.
[0057] Table 3 Interquartile ranges of GP73, ALT, AST in patients with different liver tissue inflammation activities
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[0059]
[0060] 2.2 The distinguishing value of serum GP73 on the activity of liver tissue inflammation
[0061] Using the pathological ...
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