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Preparationmethod of enhanced acetanilide compounds

An acetanilide and compound technology, applied in the field of preparation of acetanilide compounds, can solve problems such as many side effects and limitations, and achieve the effects of easing experimental conditions, simple operation, and improving diversity

Active Publication Date: 2017-10-10
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0002] Acetanilides are a common class of non-steroidal anti-inflammatory drugs, but due to their many side effects, the current clinical application is still very limited

Method used

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  • Preparationmethod of enhanced acetanilide compounds

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Embodiment Construction

[0012] Below in conjunction with specific embodiment, further illustrate the present invention.

[0013] A method for preparing an enhanced acetanilide compound, characterized in that the method comprises the following steps:

[0014] Mix acetanilide and diphenyldiselenide, add 5 mol% catalyst, 20 mol% first additive, 20 mol% second additive and oxidant into the reaction tube, add toluene under the protection of argon so that the concentration of the catalyst is 6.25 mmol / L, placed in an oil bath, reacted at 100°C for 24 hours to obtain a mixed liquid; after the reaction, add water and ethyl acetate to extract three times, dry the organic phase with anhydrous sodium sulfate, filter, and rotary evaporate Remove the organic solvent to obtain strengthened acetanilide compounds; the mass ratio of the acetanilide, diphenyldiselenide and oxidant is 1:2:2, and the volume ratio of the mixed liquid, water and ethyl acetate 1:1-5:0.5-1.

[0015] The catalyst is [RuCl 2 (p-cymene)] 2...

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Abstract

The invention provides a preparation method of enhanced acetanilide compounds. The preparation method is characterized by comprising steps as follows: acetanilide and diphenyldiselenide are mixed, a catalyst, a first additive, a second additive and an oxidizing agent are added, the components are subjected to a reaction, water and ethyl acetate are added, and the enhanced acetanilide compounds are obtained. The preparation method is simple to operate, and the defects of tough reaction conditions, functional groupintolerance of a substrate as well as overlong reaction step of a tradition preparation method areovercome.

Description

technical field [0001] The invention relates to a preparation method of enhanced acetanilide compounds. Background technique [0002] Acetanilides are a common class of non-steroidal anti-inflammatory drugs, but due to their many side effects, their current clinical application is still greatly limited. Selenides and thioethers have a wide range of biological activities, such as antiviral, antioxidant and antibacterial, but their unique potential anti-inflammatory activity has been the focus of research on selenides and thioethers. organoselenide compounds [0003] This project uses cheap transition metal ruthenium to catalyze the aryl ortho C-H sulfuration or selenization reaction of acetanilide compounds. The purpose is to strengthen the anti-inflammatory activity of acetanilide compounds and reduce the toxic and side effects. Contents of the invention [0004] The purpose of the patent of the present invention is to provide a method for preparing an enhanced acetanil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C319/14C07C323/41C07C391/02
CPCC07C319/14C07C391/02C07C323/41
Inventor 辜玲慧马文博
Owner CHENGDU UNIV
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