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Nanometer grade extract wall breaking technology

An extract, nano-level technology, applied in the direction of plant raw materials, plant/algae/fungus/moss ingredients, medical preparations containing active ingredients, etc. To solve problems such as large damage to mechanical equipment, it can facilitate the control of grinding parameters, ensure hygroscopicity and adsorption, and achieve uniform grinding effects.

Inactive Publication Date: 2017-10-10
蒋冰冰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, for plant-based Chinese medicinal materials with more fibers, their toughness is strong, and they are easy to deform and not easily broken after being subjected to external mechanical forces, and their strong cohesive force can offset part of external mechanical forces, and also It will increase the difficulty of crushing; thus, when crushing and grinding this type of Chinese herbal medicine, the shearing force is too small to be fully crushed, and the shearing force is too large to damage the mechanical equipment, so it is difficult to determine the parameters of crushing and grinding
In addition, the control of the water content of Chinese herbal medicines before crushing and grinding directly determines the quality of grinding and dispersion. If the humidity is too high, it will not be easily broken, and the particle size will be uneven. If the humidity is too low, it will be easy to agglomerate and difficult to disperse. Uniform nanoscale extract wall breaking technology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A nanoscale extract wall-breaking technology, comprising the following steps:

[0028] (1) Dry the ginseng in the sun or dry it at 50°C to keep the water content at 5%; in this step, if the water content is too high after drying, it is not conducive to the crushing of ginseng, and if the water content is too low, the ginseng powder with small particle size will be agglomerated , reduce the dispersibility of the powder.

[0029] (2) Put the dried ginseng in a grinder and carry out rough grinding at 1000r / min, so that the D50 of ginseng powder is lower than 2mm, pass through a 10-mesh sieve after rough grinding, and mix the ginseng fiber particles with the small powder Sieve to facilitate the secondary drying of fiber particles.

[0030] (3) Finely grind the ginseng powder that has passed through a 10-mesh sieve in step (2) at 1000 r / min, so that the D90 of the ginseng powder is lower than 0.1 mm.

[0031] (4) Carry out secondary drying to the fiber particle that has no...

Embodiment 2

[0037] A nanoscale extract wall-breaking technology, comprising the following steps:

[0038] (1) Dry the puerariae naturally or dry it at 60°C, and keep the water content at 4%; in this step, if the water content is too high after drying, it is not conducive to the pulverization of the puerariae root, and if the water content is too low, it will lead to pueraria powder with small particle size Agglomeration reduces the dispersibility of the powder.

[0039] (2) Put the dried kudzu root in a grinder and carry out coarse grinding at 1500r / min, so that the D50 of the kudzu root powder is lower than 2mm, pass through a 10-mesh sieve after the rough grinding, and sieve the kudzu root fiber particles and the powder with a small particle size Separated to facilitate secondary drying of fiber particles.

[0040] (3) Finely grind the kudzu root powder that has crossed a 10 mesh sieve in step (2) at 1500r / min, so that the D90 of the kudzu root powder is lower than 0.1mm.

[0041] (4)...

Embodiment 3

[0045] A nanoscale extract wall-breaking technology, comprising the following steps:

[0046] (1) Dry the licorice in the sun or dry it at 55°C to keep the water content at 4.5%; in this step, if the water content is too high after drying, it is not conducive to the crushing of the medicinal materials, and if the water content is too low, the licorice powder with small particle size will be agglomerated , reduce the dispersibility of the powder.

[0047] (2) Place the dried licorice in a grinder and carry out rough grinding at 1200r / min, so that the D50 of the licorice powder is lower than 2mm, pass through a 10-mesh sieve after rough grinding, and sieve the licorice fiber particles and the powder with a small particle size Separated to facilitate secondary drying of fiber particles.

[0048] (3) Finely grind the licorice powder that has passed through a 10-mesh sieve in step (2) at 1200r / min, so that the D90 of the licorice powder is lower than 0.1mm.

[0049] (4) Carry out...

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Abstract

The invention discloses a nanometer grade extract wall breaking technology aiming at plant type traditional Chinese medicinal materials with great fiber contents. The traditional Chinese medicinal materials are subjected to drying, coarse grinding, screening, secondary drying, fine grinding, mixing and ultrafine grinding to obtain traditional Chinese medicine powder with D90 being 400 to 800 nm. The powder obtained after the grinding by the method has the advantages that the particle diameter is uniform; the grain fineness distribution is narrow; the wall breaking rate is high; the effective substance dissolution-out quantity is high; the dissolution speed is high; the proper moisture absorption performance and adsorption performance are realized; the storage is convenient.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a nanoscale extract wall-breaking technology for plant fiber traditional Chinese medicines. technical background [0002] The active ingredients of botanical Chinese medicinal materials are mainly distributed in the intracellular and intercellular matrix, and mainly in the intracellular. The materials are crushed and ground to increase the cell wall breaking rate, so that the active ingredients can be released quickly and in large quantities without passing through the cell wall and cell membrane, thereby improving the utilization rate of the medicinal materials and increasing the curative effect. [0003] However, for plant-based Chinese medicinal materials with more fibers, their toughness is strong, and they are easy to deform and not easily broken after being subjected to external mechanical forces, and their strong cohesive force can offset part of exte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K36/258
CPCA61K9/14A61K36/258
Inventor 蒋冰冰
Owner 蒋冰冰
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