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A screening method for 108 over-the-counter drugs in veterinary preparations

A technology for prescription drugs and preparations, applied in the field of screening of 108 non-prescription components in veterinary drug preparations, can solve problems such as low separation efficiency, high concentration of illegal antimicrobial drugs, inability to achieve high throughput, and simultaneous detection of multiple antimicrobial drugs

Active Publication Date: 2019-06-04
河南省兽药饲料监察所
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Problems solved by technology

However, due to the shortcomings of low separation efficiency and long analysis time, ordinary liquid chromatography cannot achieve high-throughput and simultaneous detection of multiple antibacterial drugs.
Although liquid chromatography-mass spectrometry can achieve high-throughput qualitative identification, mass spectrometers are expensive, and the concentration of illegal antibacterial drugs in veterinary drug preparations is high, far exceeding the linear range of mass spectrometry detectors, which also limits the application of this method. Promote application

Method used

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  • A screening method for 108 over-the-counter drugs in veterinary preparations
  • A screening method for 108 over-the-counter drugs in veterinary preparations
  • A screening method for 108 over-the-counter drugs in veterinary preparations

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Embodiment Construction

[0100] The 108 over-the-counter drugs tested were:

[0101] (a) Sulfonamides (21 species): sulfamethoxine, sulfamethoxazole, sulfadimethoxine, sulfaquinoxaline, sulfachloropyrazine, sulfamethazine, sulfachloropyridazine, sulfapyridine , sulfamethoxine, sulfamethoxine, sulfadiazine, sulfamethazine, sulfisoxazole, benzosulfonamide, sulfanitrobenzene, sulfamethoxine, sulfathiazole, trimethoprim (synergist ), sulfamethazole (intermediate), sulfamethiadiazole (intermediate), sulfamethoxazole (intermediate); sulfisoxazole is a drug for human use;

[0102] (b) β-lactams (6 species): ampicillin, oxacillin, flucloxacillin, cefotaxime, ceftiofur, penicillin G;

[0103] (c) Tetracyclines (4 types): oxytetracycline, tetracycline, aureomycin, doxycycline;

[0104] (d) Amino alcohols (3 types): chloramphenicol (human drug, veterinary drug prohibited), thiamphenicol, florfenicol;

[0105] (e) Macrolides (8 species): tylosin, tilmicosin, tiamulin, azithromycin, clarithromycin, erythromycin...

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Abstract

The invention discloses a screening method for 122 nonprescription drugs in veterinary medicine preparations. The screening method comprises the following steps specifically: preparation of a standard working solution, analysis pretreatment of a sample to be measured, establishment and qualitative analysis of a database and the like. Through a constructed high-throughput screening and qualitative detection platform, the detection of a single compound is developed into simultaneous detection of various compounds in the field, and compared with the prior art, the technical means for detecting various compounds in one substance is more perfect, so that the cost is greatly reduced, and the work efficiency is greatly improved. The method plays an important role in veterinary medicine illegal addition and bacterial drug resistance plan implemented in the department of agriculture. Sample detection is carried out in provincial animal product quality detection center of our country, and through incomplete statistics, ten thousands of samples are popularized and applied.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug detection, and in particular relates to a screening method for 108 non-prescription ingredients in veterinary drug preparations. Background technique [0002] Veterinary drugs refer to substances (including pharmaceutical feed additives) used to prevent, treat, and diagnose animal diseases or purposely regulate animal physiological functions, mainly including: serum products, vaccines, diagnostic products, micro-ecological products, Chinese medicinal materials, Chinese patent medicines, Chemicals, antibiotics, biochemical drugs, radioactive drugs and topical insecticides, disinfectants, etc. With the continuous improvement of the per capita disposable income of urban and rural residents in my country, the huge demand for meat consumption drives the expansion of the scale of economic animals in my country year by year, which directly promotes the continuous growth of the demand for veterina...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 吴志明吴宁鹏李慧素周红霞韩立李华岑马俊徐坤邱天宝巩丹
Owner 河南省兽药饲料监察所
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