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Aegiceras corniculatum leaf n-butyl alcohol extract and preparation method and application thereof to prostatic cancer treatment

A technology for prostate cancer and n-butanol, which can be used in drug combinations, plant raw materials, medical preparations containing active ingredients, etc., and can solve problems such as disappointing clinical effects

Active Publication Date: 2017-09-19
GUANGXI UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, clinical results were disappointing

Method used

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  • Aegiceras corniculatum leaf n-butyl alcohol extract and preparation method and application thereof to prostatic cancer treatment
  • Aegiceras corniculatum leaf n-butyl alcohol extract and preparation method and application thereof to prostatic cancer treatment
  • Aegiceras corniculatum leaf n-butyl alcohol extract and preparation method and application thereof to prostatic cancer treatment

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Embodiment Construction

[0021] One, the preparation of tung flower leaf n-butanol part extract (NACL)

[0022] 1. Medicinal materials: Tung flower leaves are collected in Fangchenggang, Guangxi, and identified by Xu Mingben, Guangxi Beibu Gulf Marine Research Center as the leaves of the Tung flower tree of the family Taurus.

[0023] 2. Extraction and separation: Dried the leaves of tung flower and beat them into coarse powder (2500g), added 25 times the amount (62.5L) of 95% ethanol and soaked them for 7 days; Add pure water to the total extract to dissolve into a suspension, volatilize until there is no ethanol smell, add petroleum ether for extraction, obtain the lower aqueous phase, add ethyl acetate to the lower aqueous phase to continue extraction, and continue to add n-butyl acetate to the obtained lower aqueous phase Continue the extraction with alcohol to obtain the extract of the n-butanol part of the upper layer, and dry the extract of the n-butanol part of the upper layer in a water bath ...

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Abstract

The invention discloses an aegiceras corniculatum leaf n-butyl alcohol extract and a preparation method thereof. The method includes: soaking aegiceras corniculatum leaves into ethanol to obtain aegiceras corniculatum leaf ethanol extract; after volatilization of ethanol in the aegiceras corniculatum leaf ethanol extract, adding petroleum ether for extraction to obtain a lower water phase; adding ethyl acetate into the lower water phase to extract, then adding n-butyl alcohol after the lower water phase is obtained, continuing extraction to obtain upper n-butyl alcohol part extract, and performing water bath drying to obtain the aegiceras corniculatum leaf n-butyl alcohol extract. According to in-vitro molecular biological experiment researches, the aegiceras corniculatum leaf n-butyl alcohol extract has an anti-proliferation effect on human prostatic cancer cells PC3 and DU145 and is capable of evidently inhibiting metastasis of the human prostatic cancer cells PC3 and DU145. Therefore, the aegiceras corniculatum leaf n-butyl alcohol extract has a potential application prospect in preparation of medicines for treating prostatic cancer and can be used for preparation of the medicines for treating prostatic cancer. Deeply developing the aegiceras corniculatum leaf n-butyl alcohol extract can expand an aegiceras corniculatum utilization range to create a novel approach for cancer treatment.

Description

technical field [0001] The invention belongs to the technical field of tung flower tree, and in particular relates to a n-butanol extract of tung flower tree leaves and its preparation and application for treating prostate cancer. Background technique [0002] Mangrove plant Tung flower tree (Aegiceras corniculatum), also known as candle fruit, Langchai, red capsule, etc., is a plant of the genus Aegiceras corniculatum, which is one of the widely distributed plants of mangrove plants, generally distributed in the tropics and subtropics The middle beach and inner beach of the coast. Folk medicine records that its stem bark and leaf juice have certain curative effects on diseases such as diabetes, asthma and rheumatism. Modern pharmacological research has found that the extract of tung flower has cytotoxicity, antifungal, antidiarrheal, anti-oxidation and hepatoprotective pharmacological effects, but there is no report on the anti-cancer research of the extract of n-butanol p...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P13/08A61P35/00A61K127/00
CPCA61K36/185A61K2236/333A61K2236/35A61K2236/39A61K2236/51
Inventor 邓家刚罗花侯小涛郝二伟杜正彩易湘西谢滟谭德超冯小慧
Owner GUANGXI UNIV OF CHINESE MEDICINE
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