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Double-layer sticking sheet for treating canker sore

A technology for oral ulcers and adhesive tablets, applied in the field of adhesive tablets, can solve problems such as drug resistance, and achieve the effects of pain relief, pain relief, and increased medication convenience.

Active Publication Date: 2017-09-08
SHIJIAZHUANG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotic drugs, but also bring a series of problems such as drug resistance

Method used

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  • Double-layer sticking sheet for treating canker sore
  • Double-layer sticking sheet for treating canker sore
  • Double-layer sticking sheet for treating canker sore

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Prescription (100,000 tablets):

[0039]

[0040]

[0041] Preparation Process:

[0042] Take 50g of iodine clathrate, weigh 5000g of dextrin, 40g of hydroxypropyl methylcellulose, mix in a V-type mixer for 15min, add 2000ml of distilled water to wet the powder, and make soft material; granulate with 18 mesh nylon sieve, 110℃ Fluidized bed drying for 7 minutes, granulation with 24-mesh nylon sieve; then add 2000g carbomer, 100-mesh sieve and mix in magnesium stearate with a total particle weight of 50g, as drug-containing layer powder; use 5mm round shallow concave punch to press tablet The weight of the sheet is about 0.071g, and the adhesive layer is obtained; take 300g of polyvinyl alcohol and add it to a three-neck bottle, add 5000ml of distilled water, stir for 2 hours at 75°C-85°C, add 1g of lemon yellow pigment after the PVA is completely dissolved, and ultrasonically remove air bubbles , to obtain a uniform yellow liquid, which is sprayed on the surface o...

Embodiment 2

[0044] Prescription (100,000 tablets):

[0045]

[0046] Preparation Process:

[0047] Take 50g of iodine clathrate, weigh 5000g of dextrin, 50g of hydroxypropyl methylcellulose, mix in a V-type mixer for 15min, add 2000ml of distilled water to wet the powder, and make soft material; granulate with 18 mesh nylon sieve, 110℃ Fluidized bed drying for 7 minutes, granulation with 24-mesh nylon sieve; then add 2000g carbomer, 100-mesh sieve and mix in magnesium stearate with a total particle weight of 50g, as drug-containing layer powder; use 5mm round shallow concave punch to press tablet The weight of the sheet is about 0.071g, and the adhesive layer is obtained; take 300g of polyvinyl alcohol and add it to a three-neck bottle, add 4000ml of distilled water, stir for 2 hours at 75°C-85°C, add 1g of lemon yellow pigment after the PVA is completely dissolved, and ultrasonically remove air bubbles , to obtain a uniform yellow liquid, which is sprayed on the surface of the adhesi...

Embodiment 3

[0049] Prescription (100,000 tablets):

[0050]

[0051]

[0052] Process:

[0053] Take 50 grams of iodine clathrate, weigh 6000 grams of dextrin, 40 g of hydroxypropyl methylcellulose, mix in a V-type mixer for 15 minutes, add 2000 ml of distilled water to wet the powder, and make soft materials; granulate with 18-mesh nylon sieve, 110 Dry on a fluidized bed at ℃ for 6 minutes, granulate with a 24-mesh nylon sieve; then add 2000 g of carbomer, and mix in a 100-mesh sieve with magnesium stearate with a total particle weight of 60 g as the drug-containing layer powder; press with a 5 mm round shallow concave punch piece. The weight of the sheet is about 0.070g, and the adhesive layer is obtained; take 300g of polyvinyl alcohol and add it to a three-neck bottle, add 5000ml of distilled water, and stir for 2 hours at 75°C-85°C; after the PVA is completely dissolved, add 2g of lemon yellow pigment, and ultrasonically remove air bubbles. Obtain a uniform yellow liquid; spr...

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PUM

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Abstract

The invention relates to a sticking sheet for treating canker sore. The sticking sheet comprises a sticking layer and a protection layer, wherein the sticking layer is prepared from iodine inclusion compounds, disintegrants, bonding agents and glidants; the protection layer is prepared from hydrophobic materials. The sticking sheet for treating canker sore is prepared by combining the materials according to a certain ingredient proportioning ratio; the cooperated effect of all ingredients can be sufficiently achieved, so that the treatment period of the canker sore can be shortened; the treatment pain of patients with canker sore can be reduced, so that the canker sore symptom of the patient can be fast and effectively relieved.

Description

technical field [0001] The invention relates to an iodine-containing pasting tablet for treating oral ulcers, which belongs to the technical field of medicine, in particular to the technical field of pharmaceutical preparations in the medical technology. Background technique [0002] Oral ulcer is commonly called as aphtha, is a kind of common oral mucosa disease. Recurrent oral ulcers refer to a class of unexplained, recurrent but self-healing, elliptical or oval ulcers. Also known as recurrent aphthous ulcer or recurrent aphthous ulcer. Clinically, it can be divided into three types according to the size, depth and number of ulcers: recurrent mild oral ulcers, recurrent stomatitis ulcers and recurrent necrotizing mucosal periadenitis. [0003] Recurrent oral ulceration is one of modal diseases in oral mucosa disease. In a person's life, there are almost no oral ulcers that do not occur, but someone happens occasionally, and someone shows up frequently; about 20% of peop...

Claims

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Application Information

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IPC IPC(8): A61K9/32A61K33/18A61K47/69A61K47/32A61K47/38A61K47/36A61P1/02
CPCA61K9/0002A61K9/006A61K9/2027A61K9/2054A61K9/2059A61K9/284A61K33/18
Inventor 常明郧海丽李铮周冉
Owner SHIJIAZHUANG UNIVERSITY
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