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Traditional Chinese medicine composition for preventing neonatal jaundice and application

A technology for neonatal jaundice and composition, which can be applied in directions such as drug combination, pharmaceutical formula, plant raw material, etc., can solve the problems of thrombocytopenia, liver function damage and the like, and achieve the effects of low cost, less medicinal taste and easy quality control.

Inactive Publication Date: 2017-08-29
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Phototherapy, exchange transfusion, or improving glucuronosyltransferase activity in early birth are the main means to prevent neonatal jaundice at present, all of which have certain curative effects, but often have adverse reactions such as nausea, vomiting, rash, and diarrhea
In addition, for neonatal jaundice caused by viral infection, ganciclovir is selected as the first-line drug for human cytomegalovirus (HCMV) infection in infants, but long-term prevention of this drug may cause peripheral blood leukopenia and thrombocytopenia, liver damage, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1 Granule preparation of the present invention

[0011] The composition of the pharmaceutical composition: 100 parts of honeysuckle, 100 parts of skullcap, and 100 parts of gardenia.

[0012] Preparation:

[0013] (1) The above three herbs, honeysuckle, scutellaria, gardenia plus 10 times the amount of 70% ethanol reflux extraction for 1.0 hour, a total of two extractions, combined extracts, recovery of ethanol. Concentrate under reduced pressure at 60°C until the relative density of the medicinal solution is 1.05 (measured at 30°C), and remove impurities by centrifugation at 14,000 rpm in a tubular centrifuge. The centrifuged liquid was combined with the alcohol-extracted drug solution, concentrated under reduced pressure at 60°C to a relative density of the drug solution of 1.15 (measured at 60°C). The concentrated solution is prepared into extract powder with a spray drier (controlling the spray speed to be 2000ml / min, the temperature of the air inlet is...

Embodiment 2

[0015] Embodiment 2 tablet preparation of the present invention

[0016] The composition of the pharmaceutical composition: 100 parts of honeysuckle, 100 parts of skullcap, and 100 parts of gardenia.

[0017] Preparation:

[0018] (1) The above three herbs, honeysuckle, scutellaria, gardenia plus 10 times the amount of 70% ethanol reflux extraction for 1.0 hour, a total of two extractions, combined extracts, recovery of ethanol. Concentrate under reduced pressure at 60°C until the relative density of the medicinal solution is 1.05 (measured at 30°C), and remove impurities by centrifugation at 14,000 rpm in a tubular centrifuge. The centrifuged liquid was combined with the alcohol-extracted drug solution, concentrated under reduced pressure at 60°C to a relative density of the drug solution of 1.15 (measured at 60°C). The concentrated solution is prepared into extract powder with a spray drier (controlling the spray speed to be 2000ml / min, the temperature of the air inlet is ...

Embodiment 3

[0020] Embodiment 3 capsule preparation of the present invention

[0021] The composition of the pharmaceutical composition: 100 parts of honeysuckle, 100 parts of skullcap, and 100 parts of gardenia.

[0022] Preparation:

[0023] (1) The above three herbs, honeysuckle, scutellaria, gardenia plus 10 times the amount of 70% ethanol reflux extraction for 1.0 hour, a total of two extractions, combined extracts, recovery of ethanol. Concentrate under reduced pressure at 60°C until the relative density of the medicinal solution is 1.05 (measured at 30°C), and remove impurities by centrifugation at 14,000 rpm in a tubular centrifuge. The centrifuged liquid was combined with the alcohol-extracted drug solution, concentrated under reduced pressure at 60°C to a relative density of the drug solution of 1.15 (measured at 60°C). The concentrated solution is prepared into extract powder with a spray drier (controlling the spray speed to be 2000ml / min, the temperature of the air inlet is...

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PUM

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Abstract

The invention provides a traditional Chinese medicine composition for preventing neonatal jaundice. The traditional Chinese medicine composition is prepared from the following crude drugs in parts by weight: 100 parts of flos lonicerae, 100 parts of radix scutellariae and 100 parts of fructus gardeniae. A preparation form of the medicine can be capsules, granules, tablets or powder. Based on clinical research, the security and the effectiveness of the traditional Chinese medicine composition for preventing the neonatal jaundice are verified; medicine flavor of the composition is little, the quality is easy to control, and the cost is also low. The traditional Chinese medicine composition is applied to the preparation of the traditional Chinese medicine composition for preventing the neonatal jaundice.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine composition, and relates to a traditional Chinese medicine composition for preventing neonatal jaundice, which can be used in preparing medicine for preventing neonatal jaundice. Background technique [0002] Neonatal jaundice is one of the most common diseases in neonatology. It refers to the abnormal metabolism of bilirubin in the body during the neonatal period, which causes the level of bilirubin in the blood to increase, resulting in yellow staining of the skin, mucous membrane and sclera. characteristic disease. According to the epidemiological survey of hospitalized neonates in my country, neonatal jaundice occurred in full-term infants accounted for 48.8% of all hospitalized full-term infants, and the incidence rate in China tended to increase. Neonatal jaundice can be divided into physiological and pathological. Pathological jaundice accounts for about 20% to 40% of neonatal jaundice. Du...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P1/16
CPCA61K36/355A61K36/539A61K36/744A61K2300/00
Inventor 曲凡徐鑫芬马冬梅李秋芳徐萌艳朱冰花邓庆期黄婕
Owner ZHEJIANG UNIV
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