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A gold nanosphere/melanin composite nano-photoacoustic probe with super-strong photoacoustic effect and its preparation

A technology of gold nanospheres and photoacoustic effects, which is applied in the direction of nanotechnology, nanotechnology, nanotechnology, etc. for sensing, can solve the problems of high biological toxicity, damage, and poor biocompatibility, and achieve high biological inertia, Low biological toxicity, strong photoacoustic signal effect

Inactive Publication Date: 2019-10-01
TONGJI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the composite probe has poor biocompatibility, high biotoxicity, and is easy to accumulate in biological tissues and cause damage.

Method used

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  • A gold nanosphere/melanin composite nano-photoacoustic probe with super-strong photoacoustic effect and its preparation
  • A gold nanosphere/melanin composite nano-photoacoustic probe with super-strong photoacoustic effect and its preparation
  • A gold nanosphere/melanin composite nano-photoacoustic probe with super-strong photoacoustic effect and its preparation

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Abstract

The invention relates to a gold nanosphere / melanin composite nanometer opto-acoustic probe with ultra-strong opto-acoustic effect and preparation thereof. The gold nanosphere / melanin composite nanometer opto-acoustic probe is prepared by compounding dodecylamine-modified gold nanospheres with melanin nanometer particles coating the dodecylamine-modified gold nanospheres, wherein a mass ratio of the dodecylamine-modified gold nanospheres to the melanin nanometer particles is 0.1-10: 1. Compared with the prior art, the composite nanometer opto-acoustic probe provided by the invention can realize circulation in the body for a certain period of time and can be disposed at a focus part after completion of opto-acoustic imaging; and the dissociated small-sized gold nanospheres can be removed via metabolism of the kidney and are thus prevented from accumulation in biological tissue and incurrence of damage.

Description

technical field The invention relates to the field of photoacoustic detection of tumors, in particular to a gold nanosphere / melanin composite nano-photoacoustic probe with super-strong photoacoustic effect and its preparation. Background technique Photoacoustic imaging is an emerging biodetection technology. Because of its high spatial resolution and imaging depth, real-time dynamic imaging, and simple and convenient operation, it has great potential in clinical applications. In photoacoustic imaging tests, the signal strength of photoacoustic probes plays a key role in imaging quality, so the research and development of photoacoustic probes with super-strong photoacoustic signals has attracted extensive attention. According to the source, photoacoustic probes are divided into endogenous photoacoustic probes and exogenous photoacoustic probes. Endogenous photoacoustic probes are derived from living organisms and have good biocompatibility and low biotoxicity. Exogenous phot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/17B82Y15/00
Inventor 刘萍李永勇任天斌董海青
Owner TONGJI UNIV
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