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Methods for monitoring CD4+ t-helper type 1 response in cancer and immune restoration

A cancer, cell technology, applied in chemical instruments and methods, immunoglobulins, measuring devices, etc., can solve problems such as unclear role

Inactive Publication Date: 2017-08-18
THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, systemic anti-HER2 CD4 + The role of the Th1 response is unclear

Method used

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  • Methods for monitoring CD4+ t-helper type 1 response in cancer and immune restoration
  • Methods for monitoring CD4+ t-helper type 1 response in cancer and immune restoration
  • Methods for monitoring CD4+ t-helper type 1 response in cancer and immune restoration

Examples

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example

[0176] The preferred embodiments are further described in detail with reference to the following test examples. These examples are provided for illustrative purposes only and are not intended to be limiting unless otherwise specified. Therefore, the preferred embodiments should never be construed as being limited to the following examples, but rather should be construed as including any and all changes, which become obvious as a result of the teaching provided herein.

[0177] Without further description, those skilled in the art believe that they can, using the previous description and the following examples, manufacture and utilize this embodiment and practice the required method. Therefore, the following working examples specifically point out the preferred embodiments, and cannot be interpreted as any manner limited to the rest of the disclosure.

[0178] The following reference examples include methods, results and discussion sections.

[0179] Reference example

[0180] metho...

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Abstract

A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprises: generating a circulating anti-cancer CD4+ Th1response from antigen presenting cells or their precursors and CD4+ T-cells from a sample of said subject's blood which causes secretion of interferon-gamma (IFN-gamma); and detecting said anti-cancer CD4+ Th1 response to determine if said response is depressed. A method for restoring HER2-specific CD4+ Th1immune response in a HER2 -positive breast cancer patient in need thereof, comprises: administering to said patient a therapeutically effective amount of a dendritic cell (DC) vaccine comprising autologous DCs pulsed with HER2 -derived MHC class II binding peptides (DC vaccination) to elevate said patient's anti-HER2 CD4+ Th1 response; and measuring said anti-HER2 Th1 response of said patient pre- and post-DC vaccination to determine the amount of increase in said response.

Description

[0001] This application claims the priority and rights of the U.S. Provisional Patent Application serial number 61 / 953,726 filed on March 14, 2014. [0002] Thanks [0003] This application was developed with partial support from the National Institutes of Health grant number R01 CA096997. The government has certain rights in this application. Technical field [0004] This example addresses the gradual loss of immune response in cancer, especially anti-HER2 / neu CD4 + Type 1 T helper cells ("Th1") respond to the loss in HER2-driven breast cancer and its recovery, and diagnostic monitoring methods, treatment methods and tools based thereon. Background technique [0005] Breast cancer ("BC") is the leading cause of cancer-related mortality worldwide. See, Jemal, A., etc., Global Cancer Statistics. CA: Journal of Cancer Clinicians 61: 69-90 (2011). Through the development of gene expression markers, at least four prominent breast tumor phenotypes are now recognized: luminal A and lumi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/15
CPCG01N33/56972G01N33/57415A61K38/10G01N33/6866A61K2039/57G01N2333/57G01N2800/50A61P15/00A61P35/00A61P37/04A61K39/464406A61K39/4622A61K39/4615A61K2239/38A61K2239/31A61K2239/49A61K2300/00C07K16/32A61K2039/5158A61K2039/5154A61K2039/505C07K2317/24G01N2800/7028A61K35/17A61K39/001106
Inventor 加里·K·科斯基乔休德普·达塔
Owner THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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