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Nitration method of aromatic compounds

A technology for aromatic compounds and mixtures, which is applied in the field of nitration of aromatic compounds, can solve the problems of uneven mixing of tank reactors, flammable and explosive organic substances, complicated processes, etc., so as to improve production efficiency and product quality and avoid side effects. The effect of less reaction and material accumulation

Active Publication Date: 2017-08-11
北京化工大学苏州(相城)研究院 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, most of the reactors used for nitration reaction are multi-tank series stirred tank reactors. Tank reactors have disadvantages such as uneven mixing, more by-products, and complicated processes.
In addition, most of the nitrification reactions are violent and exothermic, and the heat dissipation of ordinary kettle-type nitrification equipment is not good, and a large amount of materials are accumulated in the nitrification reactor equipment, and most of the organic matter is flammable and explosive, so there is a huge potential safety hazard

Method used

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Examples

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Embodiment 1

[0031] Example 1 uses a high-gravity rotating packed bed as the core reactor device, and sets the high-gravity level to 2g-5g. Take a certain amount of sulfuric acid, nitric acid, and water to form a mixed acid, and input the benzene and mixed acid into the supergravity reactor 1 at the same time. The materials are efficiently mixed in the supergravity reactor and nitrated. After heat exchange, it enters the stratifier 3. After stratification, the crude product in the upper layer is treated as the final product through subsequent purification, and the waste acid obtained by stratification enters the waste acid recovery device 4. After concentration, the waste acid is mixed with nitric acid to obtain mixed acid. , to be recycled again, and will be input into the high-gravity reactor 1 simultaneously with benzene. Relevant conditions of the reaction are shown in Table 1. After analysis and detection, the yield was 99%.

Embodiment 2

[0032] Example 2 uses a supergravity rotating packed bed as the core reactor device, and sets the supergravity level to 800g. Take a certain amount of sulfuric acid, nitric acid, and water to form a mixed acid, and input the toluene and the mixed acid into the supergravity reactor 1 at the same time. The materials are efficiently mixed in the supergravity reactor and nitrated. After heat exchange, it enters the stratifier 3. After stratification, the crude product in the upper layer is treated as the final product through subsequent purification, and the waste acid obtained by stratification enters the waste acid recovery device 4. After concentration, the waste acid is mixed with nitric acid to obtain mixed acid. , recycle, and will be input in the high-gravity reactor 1 simultaneously with toluene. Relevant conditions of the reaction are shown in Table 1. After analysis and detection, the yield was 99.2%.

Embodiment 3

[0033] Embodiment 3 uses a baffle type supergravity device as the core reactor device, and sets the supergravity level to 150g. A certain amount of sulfuric acid, nitric acid, and water are mixed to form a mixed acid, and the chlorobenzene and the mixed acid are simultaneously input into the supergravity reactor 1, and the materials are efficiently mixed in the hypergravity reactor and nitration reaction occurs, and the reacted materials enter the heat exchanger 2, After heat exchange, it enters the stratifier 3. After stratification, the crude product in the upper layer is treated as a final product through subsequent purification. The waste acid obtained by stratification enters the waste acid recovery device 4, and the waste acid is concentrated and mixed with nitric acid to obtain Mixed acid, recycled, will be input in the high gravity reactor 1 simultaneously with chlorobenzene. Relevant conditions of the reaction are shown in Table 1. After analysis and detection, the yi...

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Abstract

The invention discloses a nitration method of aromatic compounds and particularly relates to a method for nitrating aromatic compounds in a supergravity reactor. The method comprises steps as follows: the aromatic compounds and mixed acid are input into the supergravity reactor, mixed and subjected to a nitration reaction to produce a nitration product. The nitration method of the aromatic compounds has the characteristics of being high in production efficiency, low in energy consumption and the like and is environment-friendly, safe, efficient and low-cost.

Description

technical field [0001] The invention relates to a method for nitrating aromatic compounds, in particular to a method for nitrating aromatic compounds using a high-gravity reactor, and belongs to the technical field of organic synthesis. Background technique [0002] Aromatic nitro compounds, the products of nitration of aromatic compounds, are important organic reaction intermediates, which are widely used in the fields of medicine, pesticides, dyes, spices, explosives, and organic synthesis reagents. The deep-processing products of their derivatives have high Therefore, the development and application of aromatic nitro compounds can create certain economic benefits and good social benefits. For example, the nitro group can be converted into other substituents, especially amino compounds, which are the monomers of some dyes, drugs, and polymers, and can also use the strong electron-withdrawing properties of the nitro group to activate nucleophilic reactions. The strong pola...

Claims

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Application Information

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IPC IPC(8): C07C201/08C07C205/11C07C205/12C07C205/57
CPCY02P20/10
Inventor 陈建峰黄熙赵宏高立东初广文
Owner 北京化工大学苏州(相城)研究院
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