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Injectable filler and method for its preparation

A technology for fillers and water for injection, which is applied in the field of injectable fillers and their preparation, can solve the problems of short duration of effect and large side effects of filling materials, and achieves the effects of high safety level, low cost and good application prospects.

Active Publication Date: 2020-12-01
SHANGHAI REBONE BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide an injectable filler and its preparation method in order to overcome the defects of large side effects and short duration of effect of the filling material in the prior art

Method used

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  • Injectable filler and method for its preparation

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Experimental program
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Effect test

Embodiment 1

[0030] (1) Put hydroxyapatite with a particle size of 0.01-80 μm into a high-temperature muffle furnace, raise the temperature to 800°C at a heating rate of 200°C / h in 4 hours, and sinter for 2.5 hours to obtain crystalline calcium phosphate;

[0031] (2) Mix methylcellulose and water for injection, stir in a vacuum mixer at 100 rpm for 30 minutes, and react at 25°C for 24 hours to obtain a hydrogel prepolymer;

[0032] (3) Mix the obtained crystalline calcium phosphate with the obtained hydrogel prepolymer, and stir in a vacuum mixer at 100 rpm for 15 minutes to obtain a calcium phosphate hydrogel;

[0033] Wherein, the mass ratio of the methyl cellulose to the water for injection is 1:15; the mass ratio of the crystalline calcium phosphate to the hydrogel prepolymer is 1:3.

[0034] Effect data: the pH value of the obtained calcium phosphate hydrogel is 7; the elastic modulus at 0.7Hz (closest to the frequency of the human body) is 590Pa; it has good biocompatibility, and th...

Embodiment 2

[0036] (1) Put tricalcium phosphate with a particle size of 0.01-80 μm into a high-temperature muffle furnace, heat up to 950°C at a heating rate of 300°C / h in 3 hours, and sinter for 2 hours to obtain crystalline calcium phosphate;

[0037] (2) Mix sodium alginate and water for injection, stir in a vacuum mixer at 100 rpm for 30 minutes, and react at 50°C for 6 hours to obtain a hydrogel prepolymer;

[0038] (3) Mix the obtained crystalline calcium phosphate with the obtained hydrogel prepolymer, and stir in a vacuum mixer at 100 rpm for 15 minutes to obtain a calcium phosphate hydrogel;

[0039] Wherein, the mass ratio of the sodium alginate to the water for injection is 1:25; the mass ratio of the crystalline calcium phosphate to the hydrogel prepolymer is 1:9.

[0040] Effect data: the pH value of the obtained calcium phosphate hydrogel is 6.7; the elastic modulus at 0.7Hz (closest to the frequency of the human body) is 523Pa; it has good biocompatibility, and the cytotoxi...

Embodiment 3

[0042] (1) Put tricalcium phosphate and hydroxyapatite with a particle size of 0.01-80 μm and a mass ratio of 1:1 into a high-temperature muffle furnace, and raise the temperature to 1050 °C in 2.5 hours at a heating rate of 400 °C / h , sintered for 2.5 hours to obtain crystalline calcium phosphate;

[0043](2) Mix sodium carboxymethylcellulose with water for injection, stir in a vacuum mixer at 100 rpm for 30 minutes, and react at 37°C for 12 hours to obtain a hydrogel prepolymer;

[0044] (3) Mix the obtained crystalline calcium phosphate with the obtained hydrogel prepolymer, and stir in a vacuum mixer at 100 rpm for 20 minutes to obtain a calcium phosphate hydrogel;

[0045] Wherein, the mass ratio of the sodium carboxymethylcellulose to the water for injection is 1:20; the mass ratio of the crystalline calcium phosphate to the hydrogel prepolymer is 1:3.

[0046] Effect data: the pH value of the obtained calcium phosphate hydrogel is 7; the elastic modulus at 0.7Hz (close...

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Abstract

The invention provides an injectable filler and a preparing method thereof. The preparing method comprises the steps of sintering calcium phosphate to obtain crystallized calcium phosphate, mixing a hydrophilic monomer with water for injection to obtain a hydrogel prepolymer through polymerization reaction, and mixing the obtained crystallized calcium phosphate with the obtained hydrogel prepolymer to obtain calcium phosphate hydrogel, wherein the particle size of the calcium phosphate is 0.01-80 [mu]m, the hydrophilic monomer is one or more of methylcellulose, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium alginate, gelatin and glycerinum, the mass ratio of the hydrophilic monomer to the water for injection is (1:99)-(1:4), and the mass ratio of the crystallized calcium phosphate to the hydrogel prepolymer is (1:19)-(1:1). The preparing method is characterized in simple process and low cost, and the prepared injectable filler is long in effect duration and low in complication rate, and can be produced in large scale.

Description

technical field [0001] The invention relates to an injectable filler and a preparation method thereof. Background technique [0002] In the past 10 years, the field of injectable fillers has developed faster and faster, and the demand for filler materials has also increased. At present, the fillers approved for use in China are mainly collagen and hyaluronic acid, but they are all alternative fillers, which cannot stimulate fibroblasts to synthesize collagen and stimulate the growth of soft tissues. The maintenance time is not long and multiple injections are required. Filling materials in the prior art have large side effects and short duration of effect, for example, the effective maintenance period of hyaluronic acid is about half a year. Therefore, how to reduce side effects and improve the duration of the effect is the key to the preparation of novel filling cosmetic products. Contents of the invention [0003] The technical problem to be solved by the present inven...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/52C08J3/075C08L1/28C08L5/04
CPCA61L27/46A61L27/52A61L2400/06C08J3/075C08J2301/28C08J2305/04
Inventor 陈菲
Owner SHANGHAI REBONE BIOMATERIALS
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