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A drug for preventing and treating epidemic hemorrhagic fever and its application

A technology of epidemic hemorrhagic fever and drugs, applied in the field of medicine, can solve problems such as shortening the course of the disease

Active Publication Date: 2019-10-29
MUDANJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, ribavirin and interferon are commonly used antiviral drugs for the treatment of epidemic hemorrhagic fever, dexamethasone and hydrocortisone are commonly used glucocorticoids for the treatment of epidemic hemorrhagic fever, and these drugs are mostly used alone in clinical practice , but the effect of relieving symptoms and shortening the course of disease is effective

Method used

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  • A drug for preventing and treating epidemic hemorrhagic fever and its application
  • A drug for preventing and treating epidemic hemorrhagic fever and its application
  • A drug for preventing and treating epidemic hemorrhagic fever and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Ribavirin, prednisone and enalapril are added with pharmaceutically acceptable excipients in a mass ratio of 2:3:1 and 0.5% (weight) of the total mass of the pharmaceutical composition. Conventional preparation method, made into injection.

Embodiment 2

[0023] Ribavirin, prednisone and enalapril are added with pharmaceutically acceptable excipients in a mass ratio of 1:4:2 and 1% (weight) of the total mass of the pharmaceutical composition, Conventional preparation methods, made into oral tablets.

Embodiment 3

[0025] Ribavirin, prednisone and enalapril are added with pharmaceutically acceptable adjuvants at a mass ratio of 1:1:1 and 0.1% (weight) of the total mass of the pharmaceutical composition. Conventional preparation method, made into infusion solution.

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PUM

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Abstract

The invention relates to a medicine for preventing and treating the epidemic hemorrhagic fever. The medicine comprises the active pharmaceutical ingredients of ribavirin, prednisone and enalapril, and the three active pharmaceutical ingredients produce a synergetic effect. The medicine effectively kills the virus, the attach time of the symptom is remarkably shortened, the crossing stage rate is increased, the occurrence rate of the complication is reduced, and the treatment needs of a patient are better met.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for preventing and treating epidemic hemorrhagic fever and its application. Background technique [0002] Epidemic hemorrhagic fever, also known as hemorrhagic fever with renal syndrome, is an acute infectious disease characterized by extensive damage to small blood vessels and capillaries throughout the body caused by Hantavirus infection, and rodents are the main source of infection. Clinically, the main manifestations are fever, hypotension, hemorrhage and kidney damage, and severe cases may die of shock. The course of the disease typically includes a fever period, a hypotensive shock period, an oliguria period, a polyuria period, and a recovery period. The course of the disease is mostly 1-3 months, and it will take longer for the complete recovery of renal function. China is a high incidence area of ​​epidemic hemorrhagic fever. The disease is pron...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7056A61K31/573A61K38/05A61P29/00A61P31/14A61P31/20A61P9/00A61P13/12A61P31/22
CPCA61K31/573A61K31/7056A61K38/05A61K2300/00
Inventor 王惠琦范景辉李慧影宋懿玲张秀梅王珺于春艳
Owner MUDANJIANG MEDICAL UNIV
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