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Application of pepper plant essential oil

A plant essential oil, the technology of the genus Piper, which is applied in the field of the preparation of medicines and health products for the treatment and prevention of Alzheimer's disease of the essential oil of the genus Piper, can solve the problems such as the treatment or prevention of Alzheimer's disease that have not been reported in the literature, and achieve improvement Toxicological safety, improvement of metabolic stability, effect of inhibiting acetylcholinesterase activity

Active Publication Date: 2017-07-21
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the literature has mainly reported that the essential oils of the genus Piper have biological activities such as insecticidal, antibacterial, antioxidant, and mosquito repellent activities, but there is no report in the literature that the essential oils of the genus Piper can treat or prevent Alzheimer’s disease in this patent
In addition, there is no previous patent related to the use of the essential oil of pepper plants in this patent to treat or prevent Alzheimer's disease

Method used

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  • Application of pepper plant essential oil
  • Application of pepper plant essential oil
  • Application of pepper plant essential oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Preparation of essential oil from plants of the genus Piper by steam distillation

[0029] South China pepper (Piper.austrosinense), mountain betel (false betel, P.sarmentosum Roxb), mountain betel (P.hancei Maxim), heather vine (P.wallichii), large leaf beetle (P.laetispicum), gland vein Betel (P.bavinnum), betel (P.puberulum), betel leaf (P.betle), betel leaf (P.senporeiense Yamam.inContrib.Fl.Kainan.), American tree pepper (P.aduncum), Hainan Betel (P.hainanense), peppercorns (P.thomsonii (C.DC.) Hook.f.), betel (P.boehmeriaefolium (Miq.) C.DC), peppercorns (P.flaviflorum C. DC.), pepper (P.nigrum L.), stems and leaves of pepper (P.hispidimervium C.DC.) were crushed by a small pulverizer, and 2kg of powder was weighed and placed in a steam distillation bottle. Soak in a large amount of pure water overnight, reflux on the volatile oil extractor for 6 hours (keep slightly boiling), collect the refluxed liquid and extract it with ether for 3 times, then dry ...

Embodiment 2

[0030] Example 2: Preparation of essential oil from plants of the genus Piper by carbon dioxide supercritical extraction

[0031] South China pepper (Piper.austrosinense), mountain betel (false betel, P.sarmentosum Roxb), mountain betel (P.hancei Maxim), heather vine (P.wallichii), large leaf beetle (P.laetispicum), gland vein Betel (P.bavinnum), betel (P.puberulum), betel leaf (P.betle), betel leaf (P.senporeiense Yamam.inContrib.Fl.Kainan.), American tree pepper (P.aduncum), Hainan Betel (P.hainanense), peppercorns (P.thomsonii (C.DC.) Hook.f.), betel (P.boehmeriaefolium (Miq.) C.DC), peppercorns (P.flaviflorum C. DC.), pepper (P.nigrum L.), stems and leaves of pepper (P.hispidimervium C.DC.) were crushed by a small pulverizer, and 2kg of powder was weighed and placed in a carbon dioxide supercritical extractor for extraction. Get pepper essential oil.

Embodiment 3

[0032] Example 3: Preparation of essential oils from plants of the genus Piper by solvent extraction

[0033] South China pepper (Piper.austrosinense), mountain betel (false betel, P.sarmentosum Roxb), mountain betel (P.hancei Maxim), heather vine (P.wallichii), large leaf beetle (P.laetispicum), gland vein Betel (P.bavinnum), betel (P.puberulum), betel leaf (P.betle), betel leaf (P.senporeiense Yamam.inContrib.Fl.Kainan.), American tree pepper (P.aduncum), Hainan Betel (P.hainanense), peppercorns (P.thomsonii (C.DC.) Hook.f.), betel (P.boehmeriaefolium (Miq.) C.DC), peppercorns (P.flaviflorum C. DC.), pepper (P.nigrum L.), stems and leaves of pepper (P.hispidimervium C.DC.) were crushed by a small pulverizer, weighed 2kg of powder and placed in an extractor, and added 4 times the amount of petroleum Ether, extract by cold immersion three times, each time for 48 hours, combine the extracts, reduce the pressure to recover the solvent, and obtain the essential oil of the pepper...

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Abstract

The invention discloses application of pepper plant essential oil, namely application of pepper plant essential oil in the preparation of drugs or health products for treating and preventing Alzheimer's disease; the application of the pepper plant essential oil in the preparation of drugs or health products for treating and preventing Alzheimer's disease is attributed to the action mechanism of the pepper plant essential oil in significantly inhibiting acetylcholinesterase activity, and in-vivo activity experiment further verifies that the pepper plant essential oil can significantly improve Alzheimer's disease and its symptoms, and the application is totally different from that of existing drugs or health products of pepper plant essential oil.

Description

technical field [0001] The invention relates to a new application of the essential oil of plants of the genus Piper, in particular to the application of the essential oil of the genus Piper in preparing medicines and health products for treating and preventing Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a neurodegenerative disease with insidious onset and progressive development. Clinically, it is characterized by comprehensive dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, personality and behavior changes, and severe negative social, occupational and life functions. The etiology of AD is still unknown. In recent years, many researchers at home and abroad have proposed various pathogenic hypotheses from different angles, such as hypocholinergic hypofunction hypothesis, inflammation and immunity hypothesis, gene mutation hypothesis, amyl...

Claims

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Application Information

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IPC IPC(8): A61K36/67A61P25/28
CPCA61K36/67
Inventor 许敏韩佳欣向彩朋李海舟杨崇仁
Owner KUNMING UNIV OF SCI & TECH
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