Keratoconjunctivitis sicca preventing and treating eye drop and preparation and application method thereof

Abstract

The invention relates to a keratoconjunctivitis sicca preventing and treating eye drop and a preparation and application method thereof. The keratoconjunctivitis sicca preventing and treating eye drop is composed of cyoloalliin, anthocyanin, dextranum, hydroxypropyl methyl cellulose, sodium chloride, potassium chloride, sodium borate, pH regulator and purified water. During application, the keratoconjunctivitis sicca preventing and treating eye drop can supplement water for eyes, form protective films on the surfaces of eyes and reduce water evaporation to effective relieve the symptoms caused by keratoconjunctivitis sicca such as dry eyes, and meanwhile, can stimulate secretion of lacrimal glands and increase the number of times of blinking; the cyoloalliin can inhibit secretion of inflammatory factors to release the clinical symptom of dry eyes and meanwhile fundamentally cure the keratoconjunctivitis sicca; besides, the keratoconjunctivitis sicca preventing and treating eye drop is free from preservatives, safe, non-irritative to eyes, high in long-term stability and applicable to wide application of prevention and treatment of various kinds of keratoconjunctivitis sicca.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to an eye drop for preventing and treating keratitis sicca / conjunctivitis and its preparation method and application. Background technique [0002] Keratoconjunctivitis sicca, also known as dry eye, refers to the abnormal tear quality and quantity or dynamics caused by various reasons, leading to tear film instability and ocular surface tissue lesions, and is characterized by ocular discomfort symptoms It is a general term for a class of diseases, and it is one of the most common eye diseases in today's society. The most common symptoms include dryness, foreign body sensation, and visual fatigue. In severe cases, the eyes will be congested and the corneal epithelium will peel off. Progressive corneal clouding and even blindness develop. There are many factors that cause keratitis sicca / conjunctivitis, mainly including aging, excessive tear evaporation caused by unreasonable use...

AI Technical Summary

Problems solved by technology

[0003] At present, clinically, the prevention and treatment of keratitis sicca / conjunctivitis mostly use artificial tears to relieve the clinical symptoms of keratoconjunctivitis sicca, or use steroid hormones or non-steroidal anti-inflammatory drugs locally to relieve ocular surface pain. Inflammation, the above treatment methods can alleviate some clinical symptoms of keratoconjunctivitis sicca to a certain extent, but they can only treat the symptoms but not the root cause, and may even lead to dependence on exogenous eye drops, and the eye drops should be avoided for long-term preservation. Eye infections caused by the application of eye drops often contain preservatives, and long-term use of eye drops containing preservatives is not conducive to the treatment of keratitis sicca / conjunctivitis, and even makes the eyes feel dry and itchy, thus aggravating dryness Clinical symptoms of chronic keratitis / conjunctivitis, severe cases cause damage to the corneal epithelium

[0004] At present, Lairan and Xinlairan eye drops, which are widely used clinically, can only form a protective film on the surface of the eyeball to slow down the evaporation of liquid on the surface of the eyeball while exogenously supplementing artificial tears, which is effective for keratitis sicca / conjunctivitis. To relieve the symptoms of discomfort, it can not fundamentally treat keratitis sicca / conjunctivitis

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