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Polysaccharide composition capable of adjusting structure of intestinal floras and applications thereof

A technology for regulating intestinal flora and composition, applied in the directions of application, drug combination, polysaccharide/gum-containing food ingredients, etc., to achieve good technical effect, improve intestinal health, and good regulating effect.

Active Publication Date: 2017-07-14
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a single konjac polysaccharide or ginseng polysaccharide can only regulate specific intestinal bacteria, and cannot be used to regulate the structural disorder of intestinal flora under different physiological or disease states, which has certain limitations.

Method used

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  • Polysaccharide composition capable of adjusting structure of intestinal floras and applications thereof
  • Polysaccharide composition capable of adjusting structure of intestinal floras and applications thereof
  • Polysaccharide composition capable of adjusting structure of intestinal floras and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of konjac polysaccharide:

[0029] Crush konjac into fine powder, dissolve in distilled water, filter to obtain konjac polysaccharide aqueous extract, add 0.005g.L -1 ~0.025g.L -1 β-glucanase, hydrolyze at 40°C-50°C for 0.5h-2h, inactivate the enzyme at 100°C, then concentrate under reduced pressure, add ethanol to the concentrated solution to make the ethanol concentration reach 45%-75%, let stand, After the precipitation, it is centrifuged to obtain an alcohol precipitation precipitate, and the ethanol is evaporated from the precipitate, and freeze-dried to obtain konjac polysaccharide.

[0030] Preparation of ginseng polysaccharide:

[0031] Take the dried ginseng decoction pieces and add distilled water, decoct 2-3 times, each time for 1.0-2.0h, filter, combine the filtrate, concentrate under reduced pressure, add ethanol to the concentrated solution to make the concentration of ethanol reach 55%-75%, let stand, After the precipitation, centrifuge to ...

Embodiment 2

[0033] Effects of the composition of konjac polysaccharide and ginseng polysaccharide (weight ratio 5:1) on the composition of intestinal flora in obese mice

[0034] Take 50 male C57BL / 6J mice, weighing 20±2g, provided by Shanghai Slack Experimental Animal Co., Ltd. 10 animals were randomly selected as the blank control group and given normal feed; the remaining 40 were given high-fat feed for 8 weeks and then divided into model control group, konjac polysaccharide group prepared in Experiment 1, ginseng polysaccharide group, konjac polysaccharide and ginseng polysaccharide group. Composition groups made according to the ratio (weight ratio 5:1), 10 in each group. Animals in the konjac polysaccharide group, ginseng polysaccharide group and composition group were given konjac polysaccharide, ginseng polysaccharide and the composition of konjac polysaccharide and ginseng polysaccharide (5:1) for 4 weeks, and the blank control group and the model control group were given equal v...

Embodiment 3

[0044] Effects of the composition of konjac polysaccharide and ginseng polysaccharide (weight ratio 1:7) on the composition of intestinal bacteria in mice with deficiency of spleen-qi and intestinal flora disorder

[0045] Male Kunming mice weighing 20±2 g were provided by Shanghai Slack Experimental Animal Co., Ltd.

[0046] They were randomly divided into blank control group, model group, konjac polysaccharide, ginseng polysaccharide and the composition group prepared in the ratio of (1:7) konjac polysaccharide and ginseng polysaccharide prepared in Experimental Example 1, with 10 animals in each group. Except for the blank group, 40 mice were hung with a weight of 5% of their own body weight on their tails. Put the weight-bearing mice into a container with a water temperature of 25±5°C and force them to swim, twice a day, with an interval of 0.5h, until exhausted each time: that is, the swimming range of the mice is gradually reduced, and the head is submerged in the water ...

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Abstract

The invention discloses a polysaccharide composition capable of adjusting the structure of intestinal floras and applications thereof. The composition is composed of konjak polysaccharide and ginseng polysaccharide according to a weight ratio of 1-99:1-99. The results of a large amount of tests show that konjak polysaccharide and ginseng polysaccharide are combined according to a specific ratio, the composition can change the intestinal floras specifically, the structure of intestinal floras is regulated, the health of intestinal tracts is improved; the konjak polysaccharide and ginseng polysaccharide are used together to generate a synergistic effect on regulating the structure of intestinal floras; and the composition can be used to treat enteric flora disturbance, is safe, and does not have any side or toxic effect.

Description

technical field [0001] The invention relates to a polysaccharide composition, in particular to a polysaccharide composition capable of regulating intestinal flora structure and application thereof. Background technique [0002] There are a large number of microorganisms living symbiotically in the human body, especially the intestinal microorganisms are the most important "endogenous environmental factors" of the human body. There are more than 100 bacterial genera and more than 400 bacterial species, and their number is about 10 times that of the human body's own cells. Modern research shows that human health is inextricably linked with gut microbes. The imbalance of intestinal flora caused by various reasons will affect the health of the human body and lead to various diseases. In recent years, the gut microbiota has been recognized as a possible pathogenic factor and therapeutic target for a variety of diseases. Prebiotics can affect the health of the body by selectivel...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P1/00A23L33/10A23L33/125
CPCA23V2002/00A61K31/715A61K2236/19A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00A23V2200/3202A23V2250/51
Inventor 李松林伍城颖沈红周姗姗龙芳张蔚周静
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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