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Application of militarine in preparation of heparin antagonist

A technology of heparin and drugs, applied in the directions of drug combination, pharmaceutical formula, antidote, etc., can solve the problem of patients not being able to perform surgery normally and affecting the recovery of patients.

Active Publication Date: 2017-07-07
GUIZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, as a standing drug for heart surgery, protamine is often in short supply in hospitals, and even the country is out of stock without substitutes, which causes many patients to be unable to perform normal operations, seriously affecting the recovery of patients.

Method used

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  • Application of militarine in preparation of heparin antagonist
  • Application of militarine in preparation of heparin antagonist
  • Application of militarine in preparation of heparin antagonist

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Experimental program
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Embodiment Construction

[0017] The technical solutions in the embodiments of the present invention are clearly and completely described below. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making creative efforts belong to the protection scope of the present invention.

[0018] The rhizoma glucoside used in this example is extracted from the plant Rhizoma Radix or obtained through synthesis, and its molecular formula is C 34 h 46 o 17 , the chemical name is bis[4-(β-D-glucopyranose oxygen) benzyl]-2-isobutyl malate.

[0019] The chemical structure is:

[0020]

[0021] The prepared medicine may contain pharmaceutical excipients or carriers, which are used to antagonize the effect of heparin for clinical use; the medicine can be prepared into pharmaceutical preparations suitable for clinical use, including injections, granules, capsules, tablets , powder, drop pill, sustained-release preparation; the administration form of ...

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PUM

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Abstract

The invention discloses new application of militarine in preparation of heparin antagonist. The molecular formula of the militarine in the invention is C34H46O17 and the chemical name is bis [4-(beta-D-glucopyranosoxy) benzyl]-2-isobutyl malate. The militarine provided by the invention can be prepared into dosage form suitable for clinical application, mainly including injection, granule, capsule, tablet, powder, pill, drug implants and etc. The effect of antagonize heparin is obvious. The pharmacological effect is similar to or identical with protamine. The invention has the advantage of no adverse reactions to human such as allergy and safety, and can be developed into the substitute of the protamine to be applied in clinic with good application prospect.

Description

technical field [0001] The present invention relates to the use of active ingredients of Chinese medicinal materials, in particular to the new application of rhizoside in the preparation of heparin antagonistic drugs. Background technique [0002] With the development of surgical technology, the application of heparin in surgery is becoming more and more frequent. It is mainly used clinically for thromboembolic diseases, myocardial infarction, cardiovascular surgery, cardiac catheterization, extracorporeal circulation, hemodialysis, etc., especially in cardiac surgery. Fields are used more generally. At the same time, the use of heparin can easily cause spontaneous bleeding, manifested as various mucosal bleeding, hemarthrosis, and wound bleeding. In severe cases, it will endanger the life of the patient. At this time, heparin antidote must be injected. [0003] Among the existing drugs, protamine is the only antidote to heparin, and since it was discovered in 1937, it has ...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61P39/02
CPCA61K31/7034
Inventor 廖尚高何迅王永林赵菲菲李靖周孟徐国波关焕玉李勇军兰燕宇黄勇
Owner GUIZHOU MEDICAL UNIV
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