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Controllable preparation method for switch nano porphyrin fluorescent sensor

A fluorescent sensor and nanotechnology, applied in chemical instruments and methods, fluorescence/phosphorescence, instruments, etc., to achieve high switch sensitivity, high controllability, and good stability

Active Publication Date: 2017-07-04
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the existing literature methods, the porphyrin fluorescence sensor method based on self-assembled and nano-sized porphyrins and quantum dots to prepare switch dual nano-effects has not been reported in the literature. The present invention proposes a self-assembled and nano-sized tetra-(4 -pyridyl)zinc porphyrin and CdTe quantum dots can controlly prepare a new type of highly sensitive switch nanoporphyrin fluorescent sensor with dual composite nanoeffects in a specific loading sequence and a buffer solution system with a suitable pH. The preparation method is simple, the process is green and environmentally friendly, the cost is low, and it is suitable for mass preparation and industrialization

Method used

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  • Controllable preparation method for switch nano porphyrin fluorescent sensor
  • Controllable preparation method for switch nano porphyrin fluorescent sensor
  • Controllable preparation method for switch nano porphyrin fluorescent sensor

Examples

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Effect test

Embodiment 1

[0023] Example 1: The schematic diagram of the preparation method of the switch nanoporphyrin fluorescent sensor is shown in 1, and the steps are as follows:

[0024] (1) Synthesis of CdTe quantum dot fluorescent probe

[0025] Dissolve cadmium dichloride (0.1142g, 12.5mM) and N-acetyl-L-cysteine ​​(0.0979g, 15mM) in 40mL of ultrapure water, stir at room temperature and pressure for 15 minutes, and then oxidize with hydrogen The pH of the solution was adjusted to 8.00 with sodium solution, and then the solution was filled with nitrogen and stirred in an ice bath for 20 minutes. Add sodium tellurite (0.0216g, 2.5mM) and stir for 15 minutes; then add sodium borohydride (0.0113g, 7.5mM) and stir for 15 minutes. Finally, the solution was put into a reaction kettle and reacted in an oven at 200° C. for 50 minutes. Cooling to room temperature yielded 2.9×10 -7 mol / LCdTe quantum dot fluorescent probe.

[0026] (2) Synthesis of tetrakis-(4-pyridyl)zinc porphyrin self-assembly solu...

Embodiment 2

[0030] Example 2: The schematic diagram of the preparation method of the switch nanoporphyrin fluorescent sensor is shown in 1, and the steps are as follows:

[0031] (1) Synthesis of CdTe quantum dot fluorescent probe

[0032] Adopt the method for step (1) in the embodiment 1 to synthesize 9 * 10 -7 mol / LCdTe quantum dot fluorescent probe, difference: replace the concentration of N-acetyl-L-cysteine ​​with: 18.75mM.

[0033] (2) Synthesis of tetrakis-(4-pyridyl)zinc porphyrin self-assembly solution

[0034] Adopt the method for step (2) in the embodiment 1 to synthesize 3.42 * 10 -5 mol / L tetrakis-(4-pyridyl)zinc porphyrin self-assembly solution.

[0035] (3) Preparation of switch nanoporphyrin fluorescent sensor

[0036] In a 1.5mL cuvette, add 200μL of 2.9×10 -8 mol / L step (1) synthesized CdTe quantum dots and the Tris-HCl buffer solution of 800 μ LpH=4.02, carry out fluorescence spectrum measurement at 540-720nm place, obtain the peak that fluorescence intensity is 86...

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Abstract

A controllable preparation method for a switch nano porphyrin fluorescent sensor. The invention belongs to the field of preparation of nano-materials. In the method, the switch nano porphyrin fluorescent sensor, which has dual-composite nano effect, can be controllably prepared by means of the photosensitive effect of self-assembled nano-crystallization tetra(4-pyridyl)zinc porphyrin and CdTe quantum dots at a specific sample adding sequence and in a buffer solution system having proper pH value. The composite sensing interface, based on the nano porphyrin and the quantum dots, is higher in switch sensitivity and better in stability than a composite sensing interface formed from common porphyrin and quantum dots. The preparation method is carried out at normal temperature and under normal pressure all the time, is simple and quick, has good controllability and has wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, and in particular relates to the controllable preparation of a novel switch nanoporphyrin fluorescence sensor. Background technique [0002] Porphyrin compounds have good photosensitivity, good chemical stability and thermal stability, and are ideal model compounds for studying sensor sensitive components. At present, optical sensors based on porphyrin compounds are mainly prepared by synthesizing materials such as nano-gold, nano-silver, metal oxides, carbon nanotubes and graphene. Quantum dots are semiconductor nanocrystals with unique optical and electronic properties. Due to quantum effects, they have discrete electronic energy levels and high fluorescence quantum yields. Therefore, there are also reports in the literature that porphyrin and quantum dots are synthesized to prepare composite nanomaterials to further improve their fluorescence properties. However, due to the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/22C09K11/06G01N21/64
CPCC07D487/22C09K11/06C09K2211/188G01N21/6428G01N2021/6432
Inventor 付海燕胡鸥杨天鸣尹桥波郭晓明范尧佘远斌
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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