Detection method of carbostyril drug residue in veterinary drug

Abstract

The invention provides a detection method of a carbostyril drug residue in a veterinary drug. The method comprises the following steps of: determining the carbostyril drug residue in the veterinary drug by means of liquid chromatography-tandem mass spectrometry; firstly, sampling a standard working liquid and a sample solution in a set liquid chromatography-tandem mass spectrometry condition; judging whether the sample contains corresponding detected objects or not, wherein the following conditions need to be met: a mass chromatographic peak retaining time in the sample solution is consistent to a mixed matrix standard working liquid with the allowable deviation of being smaller than + / -2.5%; and if the relative abundance of the set mass spectrum qualitative ions of the drug corresponding to the chromatographic peak is consistent to the relative ion abundance of the matrix standard working liquid equivalent in concentration, and the relative abundance deviation does not exceed the set specification, determining that the drug is contained. During pre-treatment of the sample by the method, the purifying process is cancelled, and the method has the characteristics of being simple in processing program, quick and high in determining accuracy rate and the like. Analyzed from a veterinary drug source, the medicinal safety of breeding industry is effectively ensured, and the animal food safety is improved.

Description

technical field [0001] The invention relates to the technical field of analytical chemistry, in particular to a detection method for quinolone drug residues in veterinary medicines. Background technique [0002] Quinolones (4-quinolones), also known as quinolones, pyruvate acids or pyridone acids, are a class of artificially synthesized antibacterial agents containing 4-quinolone basic structures that selectively inhibit bacterial DNA helicase. Since quinolones are neither microbial secretions nor analogues of microbial secretions, strictly speaking they are only synthetic antibacterial agents (Antibacterial). [0003] Quinolones antibiotics are a class of common drugs for humans and animals. Because of its broad antibacterial spectrum, strong antibacterial activity, no cross-resistance with other antibacterial drugs, and low toxic and side effects, it is widely used in animal husbandry, aquaculture and other aquaculture industries, including chickens, ducks, geese, pigs, c...

AI Technical Summary

Problems solved by technology

Due to the residues of quinolones in animal tissues, quinolones will accumulate in the human body after human consumption of animal tissues, resulting in serious resistance to the drugs in human diseases and affecting the treatment of human diseases

Long-term human consumption of animal foods containing low concentrations of quinolones can easily induce the transmission of drug resistance, thereby affecting the clinical efficacy of such drugs

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