Double-bond-containing cholesterol zwitterionic compound, preparation method thereof and ionic liquid based multiphase emulsion prepared from double-bond-containing cholesterol zwitterionic compound
A zwitterionic and ionic liquid technology, applied in the direction of steroids, organic chemistry, etc., to achieve the effect of stable interface and simple preparation method
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Embodiment 1
[0036] The cholesterol-like zwitterionic compounds containing double bonds shown in Synthesis III-1, the specific synthetic route and synthetic method are as follows:
[0037]
[0038]1. Under nitrogen protection, add 10mL dichloromethane and 0.27g (0.4386mmol) compound of formula I-1 to the three-necked flask, inject 0.3668mL (2.6316mmol) triethylamine with a needle; The acid chloride was dissolved in 10 mL of dichloromethane, stirred in an ice bath, then added dropwise to a three-necked flask, and reacted for 4 hours under an ice bath. After the reaction was completed, it was extracted with saturated saline (twice), and extracted with secondary water ( 2 times), rotary evaporation removes dichloromethane, obtains yellow colloidal solid, room temperature vacuum drying, obtains the compound of formula II-1, and its structural characterization result is: 1 H-NMR (400MHz, CDCl 3 )δ (ppm): 6.44 (1H, CHHCHCOO-), 6.16 (1H, CHHCHCOO-), 5.83 (1H, CHHCHCOO-), 5.35 (1H, -CH-(choles...
Embodiment 2
[0041] The ionic liquid multiphase emulsion was prepared by adopting the cholesterol-like zwitterionic compound containing double bonds in Example 1, and the specific method was as follows:
[0042] Dissolve 0.005g of cholesterol-like zwitterionic compounds containing double bonds in 100 μL of cyclohexane, and dissolve 0.01 g of 1-butyl-3-methylimidazole chloride in 100 μL of distilled water, then mix the two solutions, and place at room temperature Under mechanical stirring for 2 minutes, the rotating speed was 11400 rpm to obtain the ionic liquid multiphase emulsion (see figure 1 ), it can be seen from the figure that the droplet size in the obtained multiphase emulsion is uniform.
Embodiment 3
[0044] In Example 2, the chlorinated 1-butyl-3-methylimidazole used was replaced with an equal mass of 1-allyl-3-vinylimidazolium chloride salt, and the other steps were the same as in Example 2 to obtain an ionic liquid poly phase emulsion (see figure 2 ).
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