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Method for extracting chlorogenic acid

An extraction method, a technology of chlorogenic acid, applied in chemical instruments and methods, separation/purification of carboxylate, preparation of carboxylate, etc., can solve the problems of high production cost and low purity of the extract, and achieve simple extraction steps , The effect of easy process control

Inactive Publication Date: 2017-06-13
内蒙古昶辉生物科技股份有限公司
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the technical problems of high production cost and low purity of the extract existing in the existing chlorogenic acid extraction process, the present invention uses cheap and easy-to-obtain coffee beans as raw materials, and obtains the extracted chlorogenic acid containing chlorogenic acid through a relatively simplified extraction method. material, and the low-cost and non-toxic extractant is used, which is very suitable for industrial production. At the same time, the parameters in the extraction are adjusted, which can save energy consumption in the extraction process and achieve the purpose of saving production costs.

Method used

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  • Method for extracting chlorogenic acid

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Embodiment 1

[0023] After 20kg of green coffee beans were pulverized, 70% ethanol solution was added as an extractant, the mass ratio of extractant to green coffee beans was 6:1, after soaking for 1 hour, 500W microwave extraction was performed three times at a temperature of 55°C to obtain the primary extract.

[0024] The primary extract was added to simulated moving bed chromatography for separation. Wherein the adsorbent is SP207 macroporous resin, the desorbent is 50% ethanol solution, and its consumption is 3 times of the resin volume; the resin adsorption regeneration solvent is 95% ethanol solution; the elution rate is 1.5BV / h, and the temperature is 55 ℃, the pressure is 0.5MPa. Using an external heating single-effect decompression vacuum concentrator to separate the extractant from the separated extract to obtain a chlorogenic acid concentrate.

[0025] The chlorogenic acid concentrate is spray-dried, the air inlet temperature of the spray drying unit is 125°C, the air outlet te...

Embodiment 2

[0027] After 20kg of green coffee beans are crushed, add 65% ethyl acetate solution as an extractant, the mass ratio of extractant to green coffee beans is 7.5:1, after soaking for 0.5 hours, extract with 500W microwave three times at a temperature of 65°C to obtain the initial extraction liquid.

[0028] The primary extract was added to simulated moving bed chromatography for separation. Wherein the adsorbent is SP207 macroporous resin, the desorbent is 45% ethanol solution, and its consumption is 3 times of the resin volume; the resin adsorption regeneration solvent is 95% ethanol solution; the elution rate is 2.0BV / h, and the temperature is 55 ℃, the pressure is 0.5MPa. Using an external heating single-effect decompression vacuum concentrator to separate the extractant from the separated extract to obtain a chlorogenic acid concentrate.

[0029] The chlorogenic acid concentrated solution is spray-dried, the air inlet temperature of the spray drying unit is 120°C, the air ...

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Abstract

The invention relates to a method for extracting chlorogenic acid. The method is characterized by comprising the following steps: soaking the crushed green coffee bean in an extracting tank filled with an extracting agent for a preset period of time; extracting a mixture of the crushed green coffee bean and the extracting agent in the extracting tank, thereby acquiring a primary extracting solution; separating and purifying the primary extracting solution through a simulated moving bed chromatography, thereby acquiring a chlorogenic acid extracting solution; performing vacuum concentration on the chlorogenic acid extracting solution, thereby acquiring a concentrated chlorogenic acid solution and recovering the extracting agent; and spray-drying the concentrated chlorogenic acid solution, thereby acquiring the end product of chlorogenic acid. In the extracting manner of the scheme provided by the invention, the purity of the extracted chlorogenic acid is increased and the production energy consumption and the production cost are lowered.

Description

technical field [0001] The invention relates to a method for continuously extracting chlorogenic acid from green coffee beans, in particular to a method for extracting ultrahigh-purity chlorogenic acid. Background technique [0002] Chlorogenic acid (CGA), also known as coffee tannin, is widely distributed in nature and mainly exists in plants such as coffee beans and honeysuckle. Chlorogenic acid has physiological activities such as anti-oxidation, scavenging free radicals in the body, inhibiting mutations, anti-cancer, anti-leukemia, protecting cardiovascular, antibacterial and anti-virus, etc. It is one of the main active ingredients of many medicinal materials and Chinese patent medicines. The research on the biological activity of ortho acid has gradually penetrated into many fields such as food, health care products, medicine and daily chemical industry. [0003] At present, the production of green coffee bean extract mostly adopts organic solvent extraction after cru...

Claims

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Application Information

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IPC IPC(8): C07C67/48C07C67/56C07C69/732
CPCC07C67/48C07C67/56C07C69/732
Inventor 王岩贾洪涛赵永强张成亮高瑞张湃
Owner 内蒙古昶辉生物科技股份有限公司
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