MMT (montmorillonite)-Gd-DTPA (diethylenetriaminepentaacetic acid) compound, synthetic method thereof and application of MMT-Gd-DTPA compound to magnetic resonance diagnosis for digestive tract
A synthesis method and compound technology are applied in the fields of chemical preparation and drug research and development, and can solve the problems of high price, low synthesis yield, poor biocompatibility of MR oral contrast agents, etc., and achieve simple method and high synthesis yield. , the effect of large clinical application potential
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Embodiment 1
[0030] The present embodiment carries out the preparation of MMT-Gd-DTPA complex according to the following steps:
[0031] a. Weigh 1 g of MMT powder into a beaker, add 20 mL of deionized water, and disperse evenly to obtain solution A;
[0032] b. Add 0.5 g of GdCl to solution A 3 Disperse uniformly to obtain solution B;
[0033] C, put into baking oven after the solution B is transferred into the high-temperature reaction kettle, place 12 hours at 150 ℃, obtain reaction solution C;
[0034] d, the reaction solution C is centrifuged, and the product obtained is transferred to a freeze dryer and taken out after 24 hours of freeze drying to obtain a MMT-Gd complex;
[0035] e. Weigh 0.5 g of MMT-Gd complex into a beaker, add 20 mL of deionized water, and disperse evenly to obtain solution D;
[0036] f. Add 0.5 g of DTPA to solution D, and after stirring and ultrasonically dispersing uniformly, solution E is obtained;
[0037] g. At 60°C, the solution E prepared in step f ...
Embodiment 2
[0044] The present embodiment carries out the preparation of MMT-Gd-DTPA complex according to the following steps:
[0045] a. Weigh 3g of MMT powder into a beaker, add 40mL of deionized water, and disperse evenly to obtain solution A;
[0046] b. Add 3 g of GdCl to solution A 3 Disperse uniformly to obtain solution B;
[0047] C, put into baking oven after the solution B is transferred into the high temperature reaction kettle, and place at 180 DEG C for 24 hours to obtain reaction solution C;
[0048] d, the reaction solution C is centrifuged, and the product obtained is transferred to a freeze dryer and taken out after 24 hours of freeze drying to obtain a MMT-Gd complex;
[0049] e. Weigh 2.5 g of MMT-Gd complex into a beaker, add 40 mL of deionized water, and disperse evenly to obtain solution D;
[0050] f. Add 2.5 g of DTPA into solution D, and after stirring and ultrasonically dispersing uniformly, solution E is obtained;
[0051] g. At 75°C, the solution E prepare...
Embodiment 3
[0055] The present embodiment carries out the preparation of MMT-Gd-DTPA complex according to the following steps:
[0056] a. Weigh 1.5g of MMT powder into a beaker, add 40mL of deionized water, and disperse evenly to obtain solution A;
[0057] b. Add 1.5 g of GdCl to solution A 3 Disperse uniformly to obtain solution B;
[0058] C, put into baking oven after the solution B is transferred into the high-temperature reaction kettle, place 16 hours at 180 ℃, obtain reaction solution C;
[0059] d, the reaction solution C is centrifuged, and the product obtained is transferred to a freeze dryer and taken out after 24 hours of freeze drying to obtain a MMT-Gd complex;
[0060] e. Weigh 1 g of MMT-Gd complex into a beaker, add 40 mL of deionized water, and disperse evenly to obtain solution D;
[0061] f. Add 1 g of DTPA to solution D, and after stirring and ultrasonically dispersing uniformly, solution E is obtained;
[0062] g. At 70°C, the solution E prepared in step f was ...
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