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Composition with the effect of treating osteoporosis and its preparation method and application

An osteoporosis and composition technology, which is applied in the field of compositions with the effect of treating osteoporosis, can solve the problems of single Chinese medicine, different prescriptions, insignificant effects on osteoporosis, inconsistent treatment rules, etc., and achieves effective extraction. High content of ingredients, maintenance of bone mineral content, and the effect of preventing and treating osteoporosis

Active Publication Date: 2020-09-01
浙江海富海洋生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, western medicine and traditional Chinese medicine for osteoporosis are not effective in the treatment of osteoporosis, and western medicine can also cause damage to the body to some extent. Traditional Chinese medicine has different prescriptions and proven prescriptions, and the treatment principles are not uniform.

Method used

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  • Composition with the effect of treating osteoporosis and its preparation method and application
  • Composition with the effect of treating osteoporosis and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation method of the composition with the effect of treating osteoporosis, comprising the following steps:

[0032] (1) Take four-cornered clam shells, wash and dry them, calcinate them in a muffle furnace at 600°C for 4 hours, and then crush and sieve to obtain active calcium powder CaO. According to aspartic acid and active calcium powder CaO in Ca 2+ The molar ratio is 1:3, pH=4, after 3 hours of reaction at 50 °C, centrifugation to obtain the supernatant, concentrated, adding ethanol to make the final concentration of ethanol 65%, precipitation, filtration to obtain ethanol precipitate, drying, Get calcium aspartate chelate;

[0033] (2) Take Epimedium, Lycium barbarum and Polygonatum in a 1:1:1 ratio, add 5 times the amount of water to extract 3 times, each time for 2 hours, combine the filtrates, concentrate to obtain an aqueous extract, and dry to obtain a mixed extract of traditional Chinese medicine ;

[0034] (3) After mixing calcium aspartate chel...

Embodiment 2

[0036] The preparation method of the composition with the effect of treating osteoporosis, comprising the following steps:

[0037] (1) Take the four-cornered clam shells, wash and dry, calcinate in a muffle furnace at 1000°C for 1 hour, crush and sieve after cooling to obtain active calcium powder CaO. According to aspartic acid and active calcium powder CaO in Ca 2+ The molar ratio is 3:1, pH=6, after reaction at 80 °C for 1 h, centrifugation to obtain the supernatant, concentrated, adding ethanol to make the final concentration of ethanol 80%, precipitation, filtration to obtain ethanol precipitate, drying, Get calcium aspartate chelate;

[0038] (2) Take Epimedium, Lycium barbarum and Polygonatum at a ratio of 10:10:10, add 10 times the amount of water to extract twice, 1 hour each time, combine the filtrates, concentrate to obtain a water extract, and dry to obtain a mixed extract of traditional Chinese medicine ;

[0039] (3) After mixing calcium aspartate chelate with ...

Embodiment 3

[0041] The preparation method of the composition with the effect of treating osteoporosis, comprising the following steps:

[0042] (1) Take four-cornered clam shells, wash and dry, calcinate in a muffle furnace at 750°C for 3 hours, cool, pulverize and sieve to obtain active calcium powder CaO. According to aspartic acid and active calcium powder CaO in Ca 2+ The molar ratio is 1:1.5, pH=4.5, after reaction at 70°C for 1.5 hours, centrifugation to obtain the supernatant, concentrated, adding ethanol to make the final concentration of ethanol 75%, precipitation, filtration to obtain ethanol precipitate, and drying , get calcium aspartate chelate;

[0043] (2) Get Epimedium, Lycium barbarum and Polygonatum chinensis at a ratio of 10:1:1, add 6 times of water to extract for 2 times, each time for 2 hours, combine the filtrates, concentrate to obtain an aqueous extract, and dry to obtain a traditional Chinese medicine extract;

[0044] (3) After mixing calcium aspartate chelate...

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Abstract

The invention discloses a composition with a function of treating osteoporosis. The composition is prepared from the following raw materials in parts by weight: 1 to 10 parts of aspartic acid chelated calcium and 1 to 10 parts of extract of herba epimedii, fructus lycii and rhizoma polygonati. According to the composition screened through a lot of experiments, a calcium element supplement is matched with amino acid organic calcium by adopting a traditional Chinese medicine composition under the guidance of traditional Chinese medical theories; the proportion is scientific and novel; an experiment result shows that the composition provided by the invention can be used for effectively treating the osteoporosis, reinforcing kidney and strengthening bone, alleviating the loss of bones, improving the bone mineralization, promoting calcium absorption and maintaining calcium metabolic balance and the like; the composition is safe and effective and can be developed into a medicine for treating the osteoporosis.

Description

technical field [0001] The present invention relates to a composition, in particular to a composition with the effect of treating osteoporosis, its preparation method and its application. Background technique [0002] According to statistics, there are more than 200 million people with osteoporosis in the world, ranking seventh in the world's incidence of common diseases. my country is the country with the largest number of osteoporosis patients in the world, and the current number of patients is as high as 90 million. Among them, the incidence of osteoporosis in women over 60 years old is as high as 70%. With the aging of the population, the incidence of osteoporosis is also increasing. It is estimated that by 2050, the number of osteoporosis patients in my country will surge to more than 200 million, accounting for 13.2% of the population. With the prolongation of human lifespan and the advent of an aging society, the occurrence of osteoporosis is increasing, and there ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61P19/10A61K31/198A61K33/06A61K36/296A61K36/815
CPCA61K31/198A61K33/06A61K36/296A61K36/815A61K36/8969A61K2236/331A61K2236/51A61K2300/00
Inventor 刘睿吴皓王青程建明
Owner 浙江海富海洋生物科技有限公司
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