Modulators of toll-like receptors for the treatment of hiv

Abstract

Provided are methods, uses, pharmaceutical regimens, pharmaceutical compositions, and kits comprising modulators of TLR7, including those of Formula (II); and pharmaceutically acceptable salts thereof, useful in treating HIV infections.

Description

technical field [0001] The present application relates generally to compounds and pharmaceutical compositions that selectively modulate toll-like receptors, such as TLR7, and methods of using these compounds to treat human immunodeficiency virus (HIV) infection. Background technique [0002] The innate immune system provides the body's first line of defense against invading pathogens. In the innate immune response, invading pathogens are recognized by germline-encoded receptors, whose activation initiates a signaling cascade that induces cytokine expression. Innate immune system receptors have broad specificity, recognizing molecular structures that are highly conserved among different pathogens. One family of these receptors is known as Toll-like receptors (TLRs) because of their homology to receptors first identified and named in Drosophila and are present in cells such as macrophages, dendritic cells and in epithelial cells. [0003] There are at least ten different TL...

AI Technical Summary

Problems solved by technology

Although combination antiretroviral therapy (cART) and highly active antiretroviral therapy (HAART) have been able to reduce HIV viral reactivation, usually below 50 HIV RNA copies / ml plasma, no therapy has been able to eliminate non-actively replicating HIV ( HIV-infected cells, often referred to as the patient's HIV latent reservoir

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