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Electrospray ionization source device and system for mass spectrometers

An electrospray ionization source and mass spectrometer technology, which is applied in the field of mass spectrometer systems, can solve problems such as complexity, increased instrument volume, and reduced sample ionization efficiency, achieving lower detection limits and high sensitivity

Inactive Publication Date: 2017-05-17
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] During the formation of sample ions, if the ion clusters cannot be vaporized and separated sufficiently, the ionization efficiency of the sample will be reduced
In many commercial instruments, the sensitivity is improved by heating the auxiliary gas or wrapping a heating tape outside the ion transmission device. Although these methods can improve the sensitivity of the ion source to varying degrees, they are either too complicated or greatly increase the instrument’s sensitivity. The volume is not conducive to the miniaturization research of mass spectrometry instruments

Method used

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  • Electrospray ionization source device and system for mass spectrometers
  • Electrospray ionization source device and system for mass spectrometers
  • Electrospray ionization source device and system for mass spectrometers

Examples

Experimental program
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Effect test

Embodiment 1

[0095] Electrospray Ionization Source Device Coupled with Commercial Atmospheric Pressure Interface Time-of-Flight Mass Spectrometry

[0096] see figure 2 , figure 2 A schematic structural diagram of an electrospray ionization source system for a mass spectrometer provided in Example 1 of the present invention. Among them, micro injection pump 1, glass syringe 2, stainless steel metal capillary 3, metal shrapnel 4, PEEK two-way adapter 5, FEP insulating capillary sleeve 6, fused silica capillary 7, high voltage power supply 10, three-dimensional displacement adjustment frame 11, The horizontal direction adjustment device 12 and the vertical direction adjustment device 13 are composed of components such as.

[0097] The fused silica capillary 7 has an inner diameter of 0.1 mm and an outer diameter of 0.19 mm, and is placed in a FEP insulating capillary sleeve 6 with an inner diameter of 0.20 mm and an outer diameter of 1 / 16 inch. A stainless steel metal capillary 3 with an...

Embodiment 2

[0105] Electrospray ionization source device combined with self-developed rectangular ion trap mass spectrometer

[0106] Example 2 uses the above-mentioned electrospray ionization source coupled with a self-developed rectangular ion trap mass spectrometer,

[0107] see Figure 5 , Figure 5 A diagram of the overall experimental device provided for Example 2 of the present invention. Among them, 1 to 13 are the same figure 2 , 21 is a sample inlet, 22 is a metal capillary transmission line, 23 is an octopole guide rod, 24 is a hexapole rod, 25 is a low-temperature rectangular ion trap, and 26 is a photomultiplier detector.

[0108] Such as Figure 5 As shown, when using the above-mentioned electrospray ionization source device to analyze samples, first prepare the solution of the system to be studied. In this embodiment, the polypropylene glycol PPG sample is dissolved in acetonitrile, and the volume ratio of water is CH 3 CN: H 2 In the solvent of O=1:3, prepare a PPG ...

Embodiment 3

[0114] Using Electrospray Ionization Sources for Electrospray Extraction Ionization Sources

[0115] Electrospray extraction ionization (EESI) is a new type of atmospheric pressure open ion source developed on the basis of electrospray ionization source (ESI) and desorption electrospray ionization source (DESI). The EESI source is mainly composed of an electrospray channel and a sample introduction channel. The primary charged droplets ejected from the electrospray channel collide with the sample droplets ejected from the sample channel in the ion source space, and the analyte in the sample is extracted into the charged droplets, and then the desolvation process is completed to obtain the The ions of the analyte are used for subsequent mass spectrometry detection.

[0116] see Figure 7 , Figure 7 A schematic diagram of the experimental structure provided in Example 3 of the present invention. where the designation of the illustrated structure is equivalent to figure 2 ...

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Abstract

The invention provides an electrospray ionization source device for mass spectrometers. The electrospray ionization source device comprises an injector, a metal capillary tube, an insulating material capillary tube and a high-voltage power supply, wherein one end of the metal capillary tube is connected with an outlet of the injector; one end of the insulating material capillary tube is connected with the other end of the metal capillary tube; and a positive electrode or a negative electrode of the high-voltage power supply is in contact with the metal capillary tube. The electrospray ionization source device is simple, limits the size of a taylor cone by adopting the capillary tubes, controls the volume of a liquid drop and generates stable spray from the perspective of an electrospray nozzle on the premise that an electrospray ionization source does not have a heating device, thereby effectively carrying out a desolvation process, improving the electrospray efficiency and lowering the detection limit of an instrument. The electrospray ionization source device for the mass spectrometers is simple in structure and relatively high in sensitivity, and can be seamlessly connected with various types of mass spectrometers.

Description

technical field [0001] The invention relates to the technical field of mass spectrometer systems, in particular to an electrospray ionization source device and system for mass spectrometers, and in particular to an electrospray ionization source device and system for atmospheric pressure interface mass spectrometers. Background technique [0002] Mass spectrometry is currently known as one of the most sensitive and widely used analytical instruments, and is widely used in many fields such as chemistry, environment, food, and life sciences. A complete set of mass spectrometer usually consists of ionization source, mass analyzer, detector, vacuum system, electrical system and other parts, among which the most basic structural units are ionization source and mass analyzer. The progress of the mass spectrometer is essentially the progress of these two basic structural units. The research object of the mass analyzer is mainly ions, and finally the information of the mass-to-charg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/16H01J49/24
CPCH01J49/167H01J49/24
Inventor 黄伟文辉黄腾张杨
Owner UNIV OF SCI & TECH OF CHINA
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