Quantitative method for testing p-hydroxybenzoate alkyl ester compounds in sediment

A technology for parahydroxybenzoic acid and methyl hydroxybenzoate, which is applied in the field of analytical chemistry, can solve the problems of long analysis time, inconvenience of simultaneous qualitative and quantitative analysis, etc., and achieves the effect of simple steps and shortened measurement time.

Inactive Publication Date: 2017-05-17
HENAN NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem solved by the present invention is to provide a simple, efficient and time-consuming quantitative method for measuring paraben compounds in sediments. It is convenient to realize the shortcomings of simultaneous qualitative and quantitative

Method used

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  • Quantitative method for testing p-hydroxybenzoate alkyl ester compounds in sediment
  • Quantitative method for testing p-hydroxybenzoate alkyl ester compounds in sediment
  • Quantitative method for testing p-hydroxybenzoate alkyl ester compounds in sediment

Examples

Experimental program
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Embodiment

[0021] The instrument used in the experiments in this example is an Agilent 1260 / 6460 liquid chromatography-mass spectrometer.

[0022] 1. Establish and optimize mass spectrometry conditions

[0023] Dilute the single-standard stock solution of each target component to 0.2mg / L on the machine. N 2 As the collision gas, the temperature is 340°C, the flow rate is 11L / min; the pressure of the spray needle is 40Psi; the temperature of MS1 and MS2 are both set to 100°C; the scanning mode adopts multiple ion reaction detection (MRM).

[0024] The selected electrospray ion source (ESI) mode is the negative ion mode, and the capillary voltage is 3500V. According to the sensitivity of each target in the mass spectrum, the corresponding residence time is set, and the optimized paraben, p-hydroxybenzene The mass spectrometry parameters of formic acid and internal standard are shown in Table 1.

[0025] Table 1 Mass Spectrometry Conditions

[0026]

[0027] 2. Determine the chromato...

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Abstract

The invention discloses a quantitative method for testing p-hydroxybenzoate alkyl ester compounds in sediment. The p-hydroxybenzoate alkyl ester compounds comprise methyl parahydroxybenzoat MeP, ethyl p-hydroxybenzoate EtP, propyl p-hydroxybenzoate PrP, butyl p-hydroxybenzoate BuP, n-heptyl 4-hydroxybenzoate HeP and p-hydroxybenzoic acid P-HB, a monostandard of the p-hydroxybenzoate alkyl ester compounds is taken as a quantitative substance, 13C-marked methyl parahydroxybenzoat is taken as an internal standard substance, and an internal standard method is adopted for quantification. The quantitative method disclosed by the invention is relatively simple in whole steps, the testing time of a sample to be tested can be shortened to be 10 minutes, and reference data can be provided for the content of the p-hydroxybenzoate alkyl ester compounds in water body sediment.

Description

technical field [0001] The invention belongs to the technical field of analytical chemistry, and in particular relates to a quantitative method for measuring parabens in sediments, especially for measuring six kinds of parabens and their metabolite p-hydroxybenzoic acid in water sediments quantitative method. Background technique [0002] Parabens (Parabens, also known as parabens) are a class of compounds synthesized based on p-hydroxybenzoic acid and alcohol compounds. According to the different linking groups of alcohol compounds, they can be divided into parabens Methylparaben, ethylparaben, propylparaben, butylparaben, heptylparaben and benzylparaben and other compounds, the general structural formula of which is: [0003] [0004] In the formula, R is an organic group, such as Me, Et, etc. [0005] Parabens are recognized for their excellent spectrum antibacterial activity, low toxicity, and inactivity (in general, parabens are stable in air and resistant to hydro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 冯精兰赵佳慧席楠楠张飞孙剑辉
Owner HENAN NORMAL UNIV
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