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Electrochemical bio-sensing test paper, biosensor device and analyte measuring system

An analyte and biological sensing technology, applied in the field of analyte measurement, can solve the problems of increasing operation complexity, noise interference, increasing reaction time, etc., and achieve the effect of reducing measurement complexity, accurate analyte concentration, and shortening measurement time

Inactive Publication Date: 2011-07-20
TAIDOC TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, the method disclosed in the '811 patent for correcting hematocrit by blood glucose level is to provide AC and DC signals to the biological specimen in the same reaction area, and use an electrode set for detection together, because the DC signal and the AC signal are in the same reaction The area and the same electrode group are prone to noise interference or mutual interference. In addition, the hematocrit ratio and uncorrected blood glucose value obtained by separately providing AC signal plus DC offset to the specimen in the same reaction area will also interfere with each other, affecting the accuracy of measurement. , and temperature correction is required to obtain the correct blood sugar level. In addition, the AC signal provided by the method disclosed in the '811 patent needs to use more than one frequency to achieve the purpose, increasing the reaction time and increasing the complexity of the operation. In summary , the method disclosed in the '811 patent still has some defects to be further improved
[0010] In addition, in many electrochemical biosensing test papers on the market, the volume of the sample obtained will also affect the accuracy of the test; for example, when measuring the concentration of glucose in blood, it is quite sensitive to the volume of the blood sample obtained. If insufficient specimens are obtained, it will affect the operation of the entire calculation and cause misjudgment, so it is necessary to overcome this shortcoming

Method used

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  • Electrochemical bio-sensing test paper, biosensor device and analyte measuring system
  • Electrochemical bio-sensing test paper, biosensor device and analyte measuring system
  • Electrochemical bio-sensing test paper, biosensor device and analyte measuring system

Examples

Experimental program
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Effect test

Embodiment 1

[0084] Example 1: Hematocrit ratios obtained by stimulating whole blood and plasma specimens with signals of different frequencies, amplitudes and times

[0085] This embodiment provides the sample-AC plus DC offset signal on the electrochemical biosensing test paper, and provides signals of different frequencies, which are respectively 1kHz, 2kHz, 3kHz, 4kHz, and provides different amplitudes of 0.5Vpp, 0.5Vpp, 1Vpp, 1.5Vpp, and use whole blood and plasma samples respectively, and then measure the current values ​​at different time points of 5 seconds and 10 seconds respectively, and obtain the blood volume ratio through calculation, the results are as follows Figure 7 and Figure 8 shown.

[0086] Please refer to Figure 7 As shown, the left point is the whole blood sample, and the right point is the plasma sample. After providing AC signals with different frequencies and different amplitudes, and measuring the current value obtained after 5 seconds, and comparing the who...

Embodiment 2

[0088] Embodiment 2: Carrying out the correlation test of current value and hematocrit ratio

[0089] use as figure 2 The shown electrochemical biosensing test paper is tested, and the present embodiment provides an AC plus DC offset signal for the specimen of the electrochemical biosensing test paper. The frequency provided by the signal is 2kHz, and the amplitude provided is 1Vpp, and Samples with different hematocrit ratios were used respectively, and the current value after 5 seconds was measured, repeated three times, and the correlation with the corresponding hematocrit ratio was compared. The results are as follows: Figure 9 shown.

[0090] refer to Figure 9 As shown, the correlation curve between the current value and the blood volume ratio can be obtained by plotting the current value and the blood volume ratio obtained by three repetitions of the same sample and different samples.

Embodiment 3

[0091] Example 3: Hematocrit ratio calculated by using the electrochemical biosensing test paper with both the first group and the second group of electrodes covering the reaction layer

[0092] This example uses something like figure 2 The structure of the electrochemical biosensing test paper shown is tested, but the first set of electrodes and the second set of electrodes are designed to cover the reaction layer, and the samples with hematocrit ratios of 0, 20, 45, and 65 are used for testing .

[0093] During the measurement, the appropriate amount of sample is sucked into the reaction layer by capillary phenomenon on the test paper, and a direct current is provided to the first group of electrodes, and a voltage including AC voltage and DC offset is provided on the second group of electrodes, and the measurement time point is current value, and eight repetitions were performed.

[0094] Please refer to Figure 10 As shown, the first group of electrodes and the second ...

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Abstract

The invention discloses analyte measuring electrochemical bio-sensing test paper with a blood volume ratio correcting function, a biosensor device, a system and a method. The test paper comprises a first group of electrodes for detecting the concentration of an analyte and a second group of electrodes for detecting a blood volume ratio concentration, wherein the first group of electrodes and the second group of electrodes correspond to different reaction regions respectively; a reaction layer reacting with a substance to be measured is only covered on the first group of electrodes; and first signals including a direct current signal are supplied to the first group of electrodes and second signals including a fixed-frequency alternating current signal are supplied to the second group of electrodes, so that an analyte concentration and a blood volume ratio which are not corrected are further measured respectively and a more accurate analyte concentration corrected by a blood volume ratio is obtained.

Description

technical field [0001] The present invention relates to a method and system for measuring analyte with the function of correcting hematocrit (Hematocrit, Hct), in particular to a system and method for measuring the concentration of analyte in liquid, which is achieved by measuring hematocrit with another set of electrodes For the purpose of removing hematocrit interference, it can also be used to detect whether the sample volume is sufficient. Background technique [0002] With the advancement of technology and the change of living habits, some tests that used to be carried out in hospitals have now moved towards the direction of home measurement. In particular, changes in living habits have led to an increase in patients with chronic diseases, which has accelerated the development of this industry. The measurement of blood sugar is one of the testing items, and the measurement of blood sugar concentration is an important step in effective monitoring and treatment of diabete...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/66G01N27/26G01N33/50
Inventor 周泰成吴佳其李彩云陈朝旺
Owner TAIDOC TECH CORP
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