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A kind of on-line detector of propofol in blood and its application

A detection instrument, propofol technology, applied in the direction of instruments, measuring devices, scientific instruments, etc., can solve the problems of time-consuming, etc., and achieve the effect of improving detection sensitivity, low operating cost, and high cost performance

Active Publication Date: 2019-02-15
苏州邦伊医疗科技有限公司
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Problems solved by technology

However, as a complex biological sample, blood must be pretreated before chromatographic separation, which makes the above methods time-consuming and mostly offline analysis, which cannot fully meet the needs of clinical anesthesia monitoring.

Method used

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  • A kind of on-line detector of propofol in blood and its application

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Experimental program
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Embodiment Construction

[0020] The detection of propofol in blood adopts the traditional uniform field migration spectrum, and its structure diagram is shown in figure 1 . This instrument mainly includes the following parts: 1 is a human or animal waste blood storage room, 2 is a blood sample, 3 is a blood sample to be tested, 4 is an anticoagulant (sodium heparin), 5 is a high pressure (0.1-0.3) MPa) gas inlet, 6 is the blood inlet tube to be tested, 7 is sealed silica gel, 8 is carrier gas inlet, 9 is thermal analysis chamber, 10 is blood slide, 11 is heat lamp thermal analysis, 12 is fixed screw, 13 is The carrier gas outlet, 14 is the spring, 15 is the fixed screw nut, 16 is the migration tube outlet, 17 is the migration tube sample gas inlet, 18 is the migration tube ionization zone, 19 is the migration tube ion gate, 20 is the migration tube migration zone, 21 is the migration tube grid, 22 is the ion receiver of the migration tube, and 23 is the drift gas inlet.

[0021] Anesthetized human or a...

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Abstract

The invention designs an online detector for propofol in blood. The instrument uses ion mobility spectrometry as the basic detection technology, combined with sample thermal analysis and headspace sampling technology. The medical waste blood in the clinical operation of the hospital is taken as the blood sample, without complicated blood sample pretreatment, and the blood sample is sprayed to the surface of the sampling piece in the thermal analysis chamber by using a high-pressure air source. During the blood injection process, the propofol in the blood is rapidly vaporized in the thermal analysis chamber, and then carried by the carrier gas into the detector for online detection and analysis.

Description

Technical field [0001] The present invention designs an online detector for propofol in blood based on ion mobility spectroscopy technology, combined with sample thermal analysis and headspace sampling technology. The detection device and method of the present invention can be widely used in clinical drug administration depth analysis, and guide clinical anesthesiologists to accurately use drugs. Background technique [0002] Propofol is a commonly used intravenous anesthetic, which has been widely used in induction of anesthesia, maintenance of anesthesia, and sedation of critically ill patients in ICU. During the operation, the concentration of propofol in the patient's blood is often closely related to the depth of anesthesia. Therefore, the intraoperative monitoring of the concentration of propofol in the patient's blood is of great significance for anesthesia monitoring. [0003] At present, the methods used to determine propofol in blood mainly include high performance liqui...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/62
Inventor 李海洋王新李恩有张融王祯鑫渠团帅
Owner 苏州邦伊医疗科技有限公司
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