A kind of medical titanium-based metal material and its manufacturing method

A metal-based, medical technology, which is applied in the field of manganese-doped medical titanium metal materials and its manufacturing, can solve the problems of insufficient antibacterial and osteogenic healing performance, and achieve improved antibacterial and osteogenic performance, good antibacterial performance, and stable preparation process controllable effect

Active Publication Date: 2019-04-12
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the problems of insufficient antibacterial properties and osteogenic healing properties of existing medical titanium-based metal materials, the present invention provides a method for manufacturing medical titanium-based metal materials to meet the antibacterial and rapid growth rate of medical titanium-based metal materials available for clinical use. Bone Performance Requirements

Method used

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  • A kind of medical titanium-based metal material and its manufacturing method
  • A kind of medical titanium-based metal material and its manufacturing method
  • A kind of medical titanium-based metal material and its manufacturing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] After a 10mm×10mm×1mm pure titanium sheet was ultrasonically treated twice (5 minutes each time) with mixed acid (hydrofluoric acid: nitric acid: deionized water = 1:5:34), it was washed with acetone, ethanol and deionized water in sequence. Ultrasonic cleaning was performed twice for 5 minutes each time. Using plasma immersion ion implantation technology, the manganese element is implanted into the titanium substrate. The specific process parameters are shown in Table 1:

[0043] Table 1 Manganese ion implantation parameters

[0044] Injection voltage (kV)

30

Pulse width (μs)

500

Injection time (h)

1h

Background vacuum (Pa)

5×10 -3

Frequency (Hz)

5

[0045] figure 1 It is a comparison diagram of the scanning electron microscope morphology of the titanium metal material obtained through the modification treatment of this embodiment and the pure titanium surface. In the figure: a / c is pure titanium, and b / d is...

Embodiment 2

[0048] After a 10mm×10mm×1mm pure titanium sheet was ultrasonically treated twice (5 minutes each time) with mixed acid (hydrofluoric acid: nitric acid: deionized water = 1:5:34), it was washed with acetone, ethanol and deionized water in sequence. Ultrasonic cleaning was performed twice for 5 minutes each time. Using plasma immersion ion implantation technology, the manganese element is implanted into the titanium substrate. The specific process parameters are shown in Table 2:

[0049] Table 2 Manganese ion implantation parameters

[0050] Injection voltage (kV)

30

Pulse width (μs)

800

Injection time (h)

1h

Background vacuum (Pa)

5×10 -3

Frequency (Hz)

5

[0051] image 3 It is the manganese element XPS depth distribution diagram of the manganese doped modified layer obtained through the modification treatment of this embodiment. Depend on image 3 It can be seen that the manganese ion implantation depth of the ...

Embodiment 3

[0055] After a 10mm×10mm×1mm pure titanium sheet was ultrasonically treated twice (5 minutes each time) with mixed acid (hydrofluoric acid: nitric acid: deionized water = 1:5:34), it was washed with acetone, ethanol and deionized water in sequence. Ultrasonic cleaning was performed twice for 5 minutes each time. Using plasma immersion ion implantation technology, the manganese element is implanted into the titanium substrate. The specific process parameters are shown in Table 3:

[0056] Table 3 Manganese ion implantation parameters

[0057] Injection voltage (kV)

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Abstract

The invention relates to a medical titanium based metal material and a manufacturing method thereof. According to the method, manganese is directly injected into the surface and subsurface of the base of the titanium based metal material through a plasma immersion ion injection method. After manganese injection modification is conducted through the plasma immersion ion injection method, the medical titanium based metal material comprises a manganese doping modification layer. The material can continuously and slowly release manganese ions, has a certain inhibiting effect on growing of gram-negative escherichia coli and pseudomonas aeruginosa and can improve the osteogenic differentiation ability of mesenchymal stem cells among bone marrow, so that the problem that the antibacterial property and osteogenic property of an existing medical titanium material are poor is solved.

Description

technical field [0001] The invention belongs to the field of medical metal materials, and relates to a manganese-doped medical titanium metal material and a manufacturing method thereof. Background technique [0002] Due to their good mechanical properties and biocompatibility, titanium and its alloys have become the preferred hard tissue replacement materials for plastic surgery [Progress in Materials Science 2009,54:397-425.]. However, long-term clinical studies have found that the main factors leading to the failure of titanium material implant surgery today include the following two aspects: ①The biological activity of the implant surface is not ideal, resulting in poor bone regeneration ability (or slow regeneration) of the hard tissue implant, and the surrounding Poor tissue integration; ②The surface of the implant has no antibacterial properties, resulting in frequent occurrence of implant-related bacterial infections. The surface of the material plays a very importa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C14/48C23C14/16A61L27/30A61L27/06A61L27/54
CPCA61L27/06A61L27/306A61L27/54A61L2300/404A61L2300/412A61L2300/602A61L2430/02A61L2430/24C23C14/16C23C14/48
Inventor 刘宣勇
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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