Efficient separating device based on chromatographic theory

Abstract

The invention relates to the technical field of organic chemical synthesis and separation, and provides an efficient separating device based on a chromatographic theory. The device is composed of a pentagonal chromatography carrier unit and a fraction collecting unit, and organically integrates a thin-layer column chromatography separating method and a column chromatography separating method, so that the good separating effect of the thin-layer chromatography is kept, and the continuous chromatography characteristic of the column chromatography is also kept, and therefore, the efficient separating device has the characteristics of high separating efficiency, good separating effect and the like. Besides, separating speed can be further increased if the device is connected with a decompression device, so that separating time is reduced, consumption of a used mobile phase is saved, and complex TLC (Thin-Layer Chromatography) tracking work further can be saved, and therefore, the separating working efficiency is greatly improved. Besides, preparation is simple and regulation is convenient, so that the device is expected to be widely applied to the organic chemical field, especially quick separation of micro, semi-micro and small-scale organic compounds.

Description

technical field [0001] The invention relates to the technical field of organic chemical synthesis and separation, in particular to a high-efficiency separation device based on the principle of chromatography. Background technique [0002] Column chromatography is also called column chromatography. In column chromatography, a column is filled with chromatographic silica gel to form a stationary phase, and the mixed sample is added to the column and eluted with a special solvent, which constitutes the mobile phase. During the elution of the sample from the column, according to the different distribution coefficients of the components in the sample mixture in the stationary phase and the mobile phase, after repeated distributions, the different components of the sample will be separated one by one. [0003] There are two main types of packing for column chromatography: wet and dry. That is, wet packing and dry packing, both have their own advantages and disadvantages. No mat...

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Problems solved by technology

[0006] In view of the problems such as large technical difficulty, long separation period and large solvent consumption of the above column chromatography method, and the shortcomings of the thin layer chromatography method such as small separation volume and inability to continue chromatography; the purpose of the present invention is to provide a method based on High-efficiency separation device based on the principle of chromatography, organically combining the advantages of column chromatography and thin-layer chromatography, making use of strengths and circumventing weaknesses, thus effectively improving the chromatographic separation effect of the mixture

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