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Composition for improving Alzheimer's disease cognition impairment

A technology for cognitive dysfunction and Alzheimer's disease, which is applied in the field of compositions for improving cognitive dysfunction of Alzheimer's disease, can solve the problems of expensive safety, toxicology, side effects, etc. The effect of reducing the number and improving the ability of spatial learning and memory

Inactive Publication Date: 2017-04-26
INST OF HYGIENE & ENVIRONMENTAL MEDICINE PLA ACAD OF MILITARY MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above drugs all have different degrees of toxic and side effects. If they are used as preventive drugs for Alzheimer's disease for a long time, there are still problems of high price and safety and toxicity.

Method used

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  • Composition for improving Alzheimer's disease cognition impairment
  • Composition for improving Alzheimer's disease cognition impairment
  • Composition for improving Alzheimer's disease cognition impairment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A composition for improving cognitive dysfunction in Alzheimer's disease, comprising: 1000 parts of blueberry extract, 120 parts of ginkgo biloba extract, vitamin B 6 20 servings, vitamin B 12 0.02 parts, vitamin E 60 parts, vitamin C 100 parts, folic acid 0.4 parts, docosahexaenoic acid 200 parts, green tea polyphenol extract 150 parts, zinc lactate 50 parts, selenium yeast 0.05 parts.

Embodiment 2

[0019] A composition for improving cognitive dysfunction in Alzheimer's disease, comprising: 500 parts of blueberry extract, 60 parts of ginkgo leaf extract, vitamin B 6 10 servings, vitamin B 12 0.01 parts, vitamin E 30 parts, vitamin C 50 parts, folic acid 0.2 parts, docosahexaenoic acid 100 parts, green tea polyphenol extract 75 parts, zinc lactate 25 parts, selenium yeast 0.025 parts.

Embodiment 3

[0021] A composition for improving cognitive dysfunction of Alzheimer's disease, comprising by weight: 1500 parts of blueberry extract, 180 parts of ginkgo leaf extract, vitamin B 6 30 servings, vitamin B 12 0.03 parts, vitamin E 90 parts, vitamin C 150 parts, folic acid 0.6 parts, docosahexaenoic acid 300 parts, green tea polyphenol extract 225 parts, zinc lactate 75 parts, selenium yeast 0.075 parts.

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PUM

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Abstract

The invention discloses a composition for improving Alzheimer's disease cognition impairment. The composition comprises blueberry extract, Folium Ginkgo extract, vitamin B6, vitamin B12, vitamin E, vitamin C, folic acid, docosahexenoic acid, green tea polyphenol extract, zinc lactate and selenious yeast. A result of animal experiments shows that compared with AD model groups, the composition has the following advantages: obvious shortening of the latent time and obvious increase of the platform crossing frequency of experiment animal APP / PS1 mice in Morris water labyrinth experiments are realized, that is, the space learning memory ability is obviously improved; and the quantity of senile plaques in hippocampuses and cortical areas is obviously reduced, and the effect of the composition is better than individually supplemented blueberry extract. Above experiment result shows that a proper amount of the composition supplemented to an Alzheimer's disease model obviously improves the learning memory function disorder.

Description

technical field [0001] The invention relates to a composition of nutrients and plant active ingredients, in particular to a composition for improving cognitive dysfunction of Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is a progressive neurodegenerative disease that is highly age-related and difficult to cure. AD was first reported in 1906 by German neurologist Alois Alzheimer, who analyzed the brain tissue of a patient who died of an unknown mental illness. According to statistics from the Alzheimer's Association, currently about 13% of people over 65 years old in developed countries suffer from AD, and it has jumped to become the fifth leading cause of death in elderly patients. The World Health Organization (WHO) recently announced that the number of AD patients in the world will quadruple in 2025, and it is estimated that AD patients will reach 114 million by 2050. [0003] At present, the therapeutic drugs for Alzheimer's disease mainly...

Claims

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Application Information

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IPC IPC(8): A61K36/82A61P25/28A61K31/714A61K31/519A61K31/4415A61K31/375A61K31/355A61K33/30A61K31/202
CPCA61K36/82A61K31/202A61K31/355A61K31/375A61K31/4415A61K31/519A61K31/714A61K33/30A61K36/064A61K36/16A61K36/45A61K2300/00
Inventor 蒋与刚庞伟刘伟杨亚丹谭龙杨红澎孙寿丹
Owner INST OF HYGIENE & ENVIRONMENTAL MEDICINE PLA ACAD OF MILITARY MEDICAL
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