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Ciclopirox olamine film-spraying agent and preparation method thereof

A technology of ciclopirox olamine spray film agent and ciclopirox olamine, which is applied in antifungal agents, pharmaceutical formulas, medical preparations of non-active ingredients, etc., can solve problems such as unavoidable discomfort and reduce skin moisture evaporation , Easy to use and easy to apply

Inactive Publication Date: 2017-04-26
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ciclopirox olamine is a poorly soluble drug. Most of the commercially available preparations are solid or semi-solid preparations. The common ones are creams or suppositories. At present, studies on new dosage forms such as ciclopirox olamine film-coating agents and nanoemulsions have also been reported. , but unavoidable discomfort during external use, such as itching and trauma pain when externally applied to the affected area

Method used

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  • Ciclopirox olamine film-spraying agent and preparation method thereof
  • Ciclopirox olamine film-spraying agent and preparation method thereof
  • Ciclopirox olamine film-spraying agent and preparation method thereof

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Embodiment 1

[0030] composition:

[0031]

[0032] Preparation:

[0033] Dissolve Tween 80 in ethanol first, then add ciclopirox olamine and stir until dissolved, add purified water drop by drop to form a clear and transparent drug solution; mix 20kD chitosan, PVP k30 Sequentially add to the drug solution, stir until completely dissolved; add glycerin, azone, and lactic acid under stirring to form a homogeneous viscous drug-containing solution; dispense it into a spray bottle to obtain the ciclopirox amine spray film agent.

Embodiment 2

[0035] composition:

[0036]

[0037] Preparation:

[0038] Dissolve Tween 80 in ethanol first, then add ciclopirox olamine and stir until dissolved, add purified water drop by drop to form a clear and transparent drug solution; add 20kD chitosan and PVA1788 to the drug solution in sequence, and stir until completely dissolved; Add glycerin, azone, and lactic acid under stirring to form a homogeneous viscous drug-containing solution; distribute it into spray bottles to obtain ciclopirox olamine spray film agent.

Embodiment 3

[0040] composition:

[0041]

[0042] Preparation:

[0043] Dissolve Tween 80 in ethanol first, then add ciclopirox olamine and stir until dissolved, add purified water drop by drop to form a clear and transparent drug solution; mix 50kD chitosan, PVP k30 Sequentially add to the drug solution, stir until completely dissolved; add glycerin, peppermint oil, and acetic acid under stirring to form a homogeneous viscous drug-containing solution; dispense it into a spray bottle to obtain the ciclopirox olamine spray film agent.

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Abstract

The invention especially relates to a ciclopirox olamine film-spraying agent and a preparation method thereof, belonging to the field of medicinal preparations. Ciclopirox olamine is a wide-spectrum pyridone antifungal agent and has strong antifungal and fungicidal effect. The ciclopirox olamine film-spraying agent prepared in the invention is clear and transparent in appearance and uniform in color; medicinal liquid can be sprayed in the form of mist and then form a film, so dual physical and biochemical protection and treatment effects are exerted on an affected part and discomfort produced during external application is avoided; and the preparation method is simple in process, low in cost and convenient to use.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a ciclopirox amine film spray agent and a preparation method thereof. Background technique [0002] Skin disease is a general term for diseases that occur on the skin and skin appendages. It is often contagious, which not only affects health, but also causes panic and social discrimination. In recent years, the prevalence of skin diseases in my country has been increasing year by year. In 2013 and 2014, the sales of dermatology drugs in the retail pharmacy market were 9.196 billion yuan and 9.881 billion yuan, accounting for 56.3% and 53.5% of the total market size. %. [0003] Ciclopirox olamine (ciclopirox olamine) is a new type of broad-spectrum pyridone antifungal drug, which has strong antibacterial and bactericidal effects, and has strong penetration into the stratum corneum on which skin fungi depend. Good efficacy on local fungal diseases or vulvovaginal diseas...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4412A61K47/32A61K47/34A61K47/38A61K47/36A61P31/10A61P17/00A61P15/02A61P15/00
CPCA61K9/7015A61K9/0014A61K9/0034A61K31/4412A61K47/32A61K47/34A61K47/36A61K47/38
Inventor 丁杨周建平李昊天
Owner CHINA PHARM UNIV
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