Applications of polydatin, and neuron mitochondrion injury treating medicine and preparation method thereof
A polydipside and neuron technology, applied in the field of medicine, can solve the problems that the drug target of polydipside cannot be fully explained, the mechanism research is less, and the mitochondrial damage of polydipside neuron has not been reported.
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Embodiment 1
[0061] Preparation of a drug method for treating neuron mitochondrial damage, comprising the following steps:
[0062] Step 1: react TMC, triphenylphosphine and thionyl chloride in cyclohexanone solution, the reaction temperature is 80°C, the reaction time is 8h, after the reaction is completed, filter, wash the precipitate with distilled water, centrifuge, and vacuum dry to obtain Product 1;
[0063] Step 2: Dissolve the product 1 obtained in Step 1 in an ethyl acetate solution with a volume fraction of 1%, add a genipin solution with a mass fraction of 0.5% dropwise at room temperature, stir while dripping, and react for 6 hours to obtain a mixture solution;
[0064] Step 3: Sterilize the mixed solution obtained in Step 2 through a 0.22 μm filter membrane, and put it in a sterile operating table for use;
[0065] Step 4: Take 1 mL of the mixed solution obtained in Step 3 and add it to centrifuge tube 1, and add polydatin to centrifuge tube 2, add sterile water to centrifug...
Embodiment 2
[0068] Preparation of a drug method for treating neuron mitochondrial damage, comprising the following steps:
[0069] Step 1: react TMC, triphenylphosphine, and thionyl chloride in a cyclohexanone solution with a ratio of 1:1.5:1.5, the reaction temperature is 90°C, and the reaction time is 90h. After the reaction is completed, filter, The precipitate was washed with distilled water, centrifuged, and vacuum-dried to obtain product 1;
[0070] Step 2: Dissolving the product 1 obtained in step 1 in a 1% ethyl acetate solution by volume fraction, adding dropwise a genipin solution with a mass fraction of 0.5% at room temperature, the ratio of the amount of genipin to the product 1 1:1, stirring while dripping, reacted for 10h, and prepared a mixed solution;
[0071] Step 3: Sterilize the mixed solution obtained in Step 2 through a 0.22 μm filter membrane, and put it in a sterile operating table for use;
[0072] Step 4: Take 1 mL of the mixed solution obtained in Step 3 and ad...
Embodiment 3
[0075] Preparation of a drug method for treating neuron mitochondrial damage, comprising the following steps:
[0076] Step 1: react TMC, triphenylphosphine and thionyl chloride in a solution of cyclohexanone with a ratio of 1:1.5:1.5, the reaction temperature is 85°C, and the reaction time is 20h. After the reaction is completed, filter, The precipitate was washed with distilled water, centrifuged, and vacuum-dried to obtain product 1;
[0077] Step 2: Dissolving the product 1 obtained in step 1 in a 1% ethyl acetate solution by volume fraction, adding dropwise a genipin solution with a mass fraction of 0.5% at room temperature, the ratio of the amount of genipin to the product 1 1:1, stirring while dripping, reacted for 8h, and obtained a mixed solution;
[0078] Step 3: Sterilize the mixed solution obtained in Step 2 through a 0.22 μm filter membrane, and put it in a sterile operating table for use;
[0079] Step 4: Take 1 mL of the mixed solution obtained in Step 3 and a...
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