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Western medicine compound for treating fracture

A technology for the treatment of fractures and western medicine, applied in the field of western medicine, can solve the problems of adverse drug administration limitations, etc., and achieve the effects of inhibiting the formation of glial scars, wide administration window, and long-lasting therapeutic effect

Inactive Publication Date: 2017-03-22
HENAN BALING ELECTRONICS TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although a lot of research has been done on the pathophysiological mechanism of fractures in recent years, and drugs represented by methylprednisolone (MP) have also achieved certain curative effects in clinical application, but the adverse reactions of drugs and their administration Drug limitations make people continue to seek effective treatment drugs

Method used

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  • Western medicine compound for treating fracture
  • Western medicine compound for treating fracture

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Experimental program
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Effect test

Embodiment 1

[0017] In the embodiment of the present invention, a western medicine compound for treating fractures is composed of ulinastatin and levofloxacin; wherein, the mass ratio of ulinastatin and levofloxacin is 0.09:1.

Embodiment 2

[0019] In the embodiment of the present invention, a western medicine compound for treating fractures is composed of ulinastatin and levofloxacin; wherein, the mass ratio of ulinastatin and levofloxacin is 0.10:1.

Embodiment 3

[0021] In the embodiment of the present invention, a western medicine compound for treating fractures is composed of ulinastatin and levofloxacin; wherein, the mass ratio of ulinastatin and levofloxacin is 0.11:1.

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PUM

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Abstract

The invention discloses a western medicine compound for treating fracture. The western medicine compound consists of ulinastatin and levofloxacin, wherein the mass ratio of the ulinastatin to the levofloxacin is 0.09-0.13: 1; when the western medicine compound is used for treating the fracture, the injected dose of the western medicine compound for adults is 1.9-2.1 mg / kg, and the drug administration time is the time of 6-12 hours after fracture. Through testing therapy to fracture molding animals, the western medicine compound can reduce cell apoptosis, promote survival of nerve cells and inhibit formation of glial scar; BBB grade of treated animals is increased remarkably; and the western medicine has remarkable promotion effect on functional recovery of locomotion after fracture. Compared with methylprednisolone as a common drug for treating fracture, the western medicine compound is wider in administration window, is lasting in treatment effect and better in long-term effect.

Description

technical field [0001] The invention relates to the technical field of western medicine, in particular to a compound western medicine for treating fractures. Background technique [0002] Fracture is a serious complication of spinal fractures. Due to the displacement of the vertebral body or the protruding of bone fragments in the spinal canal, the fracture or cauda equina is damaged to varying degrees. It will be accompanied by fractures of the cervical, thoracic, thoracolumbar, lumbar, and sacral vertebrae, resulting in limb movement disorders, sensory disorders, and defecation disorders. It is more common in young adults, mostly males, and the most common injury site is the middle and lower cervical spinal cord, followed by the thoracolumbar junction. [0003] Fracture is composed of primary injury and secondary injury. Primary injury is tissue damage caused by external mechanical force such as impact, cutting, bleeding, etc., and is generally irreversible. Secondary inj...

Claims

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Application Information

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IPC IPC(8): A61K38/57A61P19/08A61K31/5383
CPCA61K38/57A61K31/5383
Inventor 不公告发明人
Owner HENAN BALING ELECTRONICS TECH CO LTD
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