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Human-like collagen gel for repairing gynecologic mucosa

A human-like collagen and mucous membrane technology, applied in the field of medical devices, can solve problems such as the transdermal absorption speed of collagen that is not concerned with, and achieve the effect of accelerating the transdermal absorption speed, promoting repair and good nourishment

Active Publication Date: 2017-03-15
SHAANXI GIANT BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But unfortunately, relevant researches pay more attention to the transdermal absorption rate of collagen, but not the transdermal absorption rate of collagen

Method used

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  • Human-like collagen gel for repairing gynecologic mucosa
  • Human-like collagen gel for repairing gynecologic mucosa
  • Human-like collagen gel for repairing gynecologic mucosa

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preparation example Construction

[0033] There is no special limitation on the preparation method of the human-like collagen gel of the present invention, and its preparation method may include:

[0034] Step A: preparing phase A, the phase A is composed of 0.9-1.1% by weight of carbomer, 5-10% by weight of glycerin, 0.001-0.01% by weight of sodium hyaluronate and the rest of water;

[0035] Step B: preparing phase B, which is an aqueous sodium hydroxide solution composed of 0.05-0.1% by weight of sodium hydroxide and 1-3% by weight of water;

[0036] Step C: preparing phase C, which is a mixture of 0.1-0.5% by weight of ethylparaben and 20-10% by weight of glycerin;

[0037] Step D: preparing phase D, the phase D is 0.2-1% by weight of chitosan;

[0038] Step E: preparing phase E, the phase E is a humanoid collagen liquid, which contains humanoid collagen so that the content of humanoid collagen in the humanoid collagen gynecological site mucosal repair gel is 0.1-1% by weight Collagen, the medium is water,...

Embodiment 1

[0051] Embodiment 1. Preparation of human-like collagen gynecological site mucosal repair gel of the present invention

[0052] Ingredients: carbomer 1%, glycerin 22%, sodium hyaluronate 0.005%, sodium hydroxide 0.09%, ethylparaben 0.2%, chitosan 0.5%, human-like collagen 0.5%, water balance.

[0053] Process operation:

[0054] ① Add carbomer, sodium hyaluronate, and glycerin (8% by weight) to water first, then slowly add chitosan and stir continuously until they are completely dispersed.

[0055] ② Add sodium hydroxide aqueous solution to the above solution, stir evenly, slowly add the mixture of ethylparaben and glycerin, and human-like collagen solution, stir well, keep warm at 82°C for 90 minutes, after the warming is over, Stir well and cool to room temperature.

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Abstract

The invention relates to a human-like collagen gel for repairing a gynecologic mucosa. The human-like collagen gel comprises the following ingredients: 0.1-1wt% of human-like collagen, 0.9-1.1wt% of Carbomer, 20-25wt% of glycerinum, 0.001-0.01wt% of sodium hyaluronate, 0.05-0.1wt% of sodium hydroxide, 0.1-0.5wt% of ethylparaben, 0.2-1wt% of chitosan and the balance of water. When the human-like collagen gel disclosed by the invention is applied to an epidermis of a gynecologic position with the damaged mucosa, the transdermal absorption of the human-like collagen can speed up more dramatically. Therefore, the human-like collagen gel disclosed by the invention can better nourish and stimulate mucosal cell regeneration and promote the mucosa of the damaged gynecologic position to be repaired.

Description

technical field [0001] The invention relates to a human-like collagen dressing, in particular to a gel containing human-like collagen which is particularly suitable for gynecological mucosal repair, and belongs to the field of medical devices. Background technique [0002] Human-like collagen was invented by Professor Fan Daidi of Northwest University in China (see Chinese Patent Application Publication CN1371919A), so it is also called Fan's Human-like Collagen or Fan's Human-like Collagen (FHLC). Human-like collagen is a highly biocompatible recombinant collagen that is currently widely used in medical or cosmetic fields. [0003] On the other hand, when collagen dressing products are used for moisturizing and protecting the mucous membranes of the nasal cavity, gynecological parts, and gynecological parts, the use of collagen dressing products often needs to be carried out indoors (such as otolaryngology, gynecological parts and gynecology in hospitals). etc.), as a prod...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K38/39A61K47/36A61P17/02A61L26/00
CPCA61K38/39A61K47/36A61L26/0014A61L26/0023A61L26/0033A61L26/008A61K9/06A61L2300/412A61L2300/252C08L5/08C08L33/02
Inventor 范代娣马晓轩严建亚王淑英常海燕王小军杨婵媛
Owner SHAANXI GIANT BIOTECHNOLOGY CO LTD
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