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Anti-aging external skin preparation

A skin external preparation, anti-aging technology, applied in the direction of skin care preparations, cosmetics, cosmetic preparations, etc., to achieve the effect of strengthening tight junction function, maintaining or enhancing skin barrier function, preventing or wrinkling

Active Publication Date: 2017-02-15
HAYASHIBARA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently proposed anti-aging skin external preparations are only pursuing the possibility of realizing a very small part of various possibilities. Different mechanisms for exerting anti-aging effects and good usability are also included. From the point of view of ease, the status quo is still expected to provide new anti-aging skin external preparations from various perspectives

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0040]The skin external preparation of the present invention contains adenosine N1-oxide 5'-phosphate, its analogs and salts thereof as an active ingredient. Such adenosine N1-oxide 5'-phosphate, analogues and salts thereof may be purified from natural products or chemically synthesized, regardless of their origin. The analogs of adenosine N1-oxide 5'-phosphate in the present invention, for example, can include adenosine N1-oxide or 3'-α-glucosyladenosine N1-oxide, 5'-α- Glucosyladenosine N1-oxide, adenosine N1-oxide 5'-diphosphate, adenosine N1-oxide 5'-triphosphate, etc. In addition, salts of adenosine N1-oxide 5'-phosphate in the present invention include, for example, adenosine N1-oxide 5'-sodium phosphate, adenosine N1-oxide 5'-potassium phosphate, etc. . In terms of effects, adenosine N1-oxide 5'-phosphate, adenosine N1-oxide, 3'-α-glucosyladenosine N1-oxide and 5'-α-glucosyladenosine N1 are preferred -oxide, more preferably adenosine N1-oxide 5'-phosphate, adenosine ...

Embodiment 1

[0179] [Example 1: Lotion]

[0180] 【With prescription】

[0181] Compounding ingredients (quality%) (1) Glycerin 4.0 (2) Propylene glycol 3.0 (3) 1,2-pentanediol 0.1 (4) Adenosine N1-oxide 5'-sodium phosphate 1.0 (5) polyoxyethylene (20 moles) oleyl alcohol 0.5 (6) Saxifraga extract 2.0 (7) Ethanol 5.0 (8) Spices Appropriate amount (9) Purified water margin

[0182] After dissolving the ingredients (1) to (4) of the above formulation in purified water (9), a mixture of ingredients (5) to (8) was gradually added and mixed to prepare a lotion. Due to the combination of adenosine N1-oxide 5'-sodium phosphate, this product is an excellent lotion for promoting skin renewal, as the maintenance or enhancement of skin barrier function, the maintenance or enhancement of elastin production, anti-aging It is also useful as an anti-aging lotion with excellent wrinkle effect, anti-fine line effect, anti-slack effect, ...

Embodiment 2

[0183] [Example 2: Emulsion]

[0184] 【With prescription】

[0185] Compounding ingredients (quality%) (1) 1,2-Hexanediol 5.0 (2) Octyldodecanol 4.0 (3) Adenosine N1-oxide 5'-sodium phosphate 0.1 (4) Ascorbic acid 2-glucoside (sold by Hayashibara Co., Ltd., trade name "AA2G") 2.0 (5) Polyoxyethylene oleyl ether (20E.O.) 1.0 (6) stearic acid 0.5 (7) Shea Butter 2.0 (8) Secret wax 4.0 (9) p-Hydroxybenzoate 0.2 (10) Quince Seed Extract 5.0 (11) Xanthan gum 0.1 (12) Phytic acid 0.02 (13)Vitamin E 0.01 (14) Purified water margin

[0186] The above-mentioned components (1), (3), (10), (11) and purified water (14) were mixed to form an aqueous phase. Next, components (2), (5) to (9), (12) and (13) are heated and mixed to form an oil phase. After adding a water phase to an oil phase and mixing uniformly, it cools, adds a component (4), mixes uniformly, and obtains an emulsion. Since t...

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PUM

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Abstract

The present invention addresses the problem of providing an anti-aging external skin preparation that prevents or improves problems with skin appearance such as aging, wrinkles due to aging, fine wrinkles, loose skin, and spots, and maintains or enhances skin barrier functions. The abovementioned problem is solved by providing an anti-aging external skin preparation containing, as an active ingredient, at least one substance selected from adenosine N1- oxide 5'-phosphate, and analogs and salts thereof.

Description

[0001] 【Technical field】 [0002] The present invention relates to an anti-aging skin external preparation, and more specifically, to an anti-aging agent containing, as an active ingredient, one or more kinds selected from the group consisting of adenosine N1-oxide 5'-phosphate, analogues thereof, and salts thereof. Skin external preparation. [0003] 【Background technique】 [0004] Keeping young forever is a common wish of human beings. However, with the increase of age, the changes of wrinkles, fine lines, sagging, and pigmentation on human skin have been experienced by human beings for a long time. With the increase of age, the skin also ages. Changes in the appearance of wrinkles, fine lines, sagging, and stains on the skin are natural and inevitable. [0005] However, in recent years, with the advancement of research on the structure of human skin and its metabolic mechanism, etc., the causes and structures of changes in human skin such as wrinkles, fine lines, sagging, a...

Claims

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Application Information

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IPC IPC(8): A61K8/60A61K8/44A61K8/49A61K8/67A61Q19/02A61Q19/08
CPCA61Q19/02A61Q19/08A61K8/498A61K8/676A61K31/7076A61K31/706A61K31/7064A61K8/44A61K8/606
Inventor 河野惠三宫田聪美花谷利春福田惠温
Owner HAYASHIBARA CO LTD
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