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Injection cefoperazone sodium and sulbactam sodium pharmaceutical composition for reducing allergic reaction

A technology of cefoperazone sodium sulbactam sodium and cefoperazone sodium, which is applied in the compound pharmaceutical composition of cefoperazone sodium sulbactam sodium for injection and its preparation field, can solve the problems such as weak antibacterial activity, and achieve stable product quality, related substances and The content change range is small, and the product solubility is good

Inactive Publication Date: 2017-02-15
福安药业集团庆余堂制药有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Cefoperazone Sodium Sulbactam Sodium for Injection is a third-generation cephalosporin composed of cefoperazone sodium and sulbactam sodium. Sulbactam is a broad-spectrum enzyme inhibitor and has weak antibacterial activity against Staphylococcus aureus and most β-lactamases produced by negative bacilli have strong irreversible inhibitory effects, but are inactive against certain negative chromosome-mediated β-lactamases

Method used

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  • Injection cefoperazone sodium and sulbactam sodium pharmaceutical composition for reducing allergic reaction
  • Injection cefoperazone sodium and sulbactam sodium pharmaceutical composition for reducing allergic reaction
  • Injection cefoperazone sodium and sulbactam sodium pharmaceutical composition for reducing allergic reaction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Cefoperazone Sodium Sulbactam Sodium for Injection (specification: 0.75g, calculated as available acid, 1000 bottles) and preparation:

[0038] Cefoperazone sodium (calculated as cefoperazone) 500g

[0039] Sulbactam sodium (as sulbactam) 250g

[0040] Acetic acid-sodium acetate appropriate amount

[0041] Weigh the prescribed amount of cefoperazone sodium and sulbactam sodium, dissolve them in 1200ml of water for injection, adjust the pH value of the solution to 5.6-5.8 with acetic acid-sodium acetate, add 300ml of water for injection, and add activated carbon for injection to absorb the heat source. 0.45μm and 0.22μm pore size membrane filters are sterile filtered, and the sterile solution is put into a bottle and freeze-dried.

Embodiment 2

[0049] Cefoperazone Sodium and Sulbactam Sodium for Injection (specification: 1.5g, calculated as available acid, 1000 bottles) and preparation:

[0050] Cefoperazone sodium (calculated as cefoperazone) 750g

[0051] Sulbactam sodium (as sulbactam) 750g

[0052] Acetic acid-sodium acetate appropriate amount

[0053] Weigh the prescribed amounts of cefoperazone sodium and sulbactam sodium, dissolve in 3600ml of water for injection, adjust the pH of the solution to 5.4-5.6 with acetic acid-sodium acetate, add 900ml of water for injection, and add activated carbon for injection to absorb the heat source. 0.45μm and 0.22μm pore size membrane filters are sterile filtered, and the sterile solution is put into a bottle and freeze-dried.

Embodiment 3

[0061] Cefoperazone Sodium Sulbactam Sodium for Injection (specification: 3.0g, calculated as available acid, 1000 bottles) and preparation:

[0062] Cefoperazone sodium (calculated as cefoperazone) 1500g

[0063] Sulbactam sodium (as sulbactam) 1500g

[0064] Acetic acid-sodium acetate appropriate amount

[0065] Weigh the prescribed amount of cefoperazone sodium and sulbactam sodium, dissolve in 9600ml of water for injection, adjust the pH value of the solution to 5.6-5.8 with acetic acid-sodium acetate, add 2400ml of water for injection, add activated carbon for injection to absorb the heat source, and use 0.45 It is obtained by sterilizing filtration through membrane filters with pore diameters of μm and 0.22 μm, filling the sterile solution into a bottle, and lyophilizing it.

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Abstract

The invention discloses an injection cefoperazone sodium and sulbactam sodium pharmaceutical composition for reducing allergic reaction and a preparation method thereof; the pharmaceutical composition is made from cefoperazone sodium and sulbactam sodium; in addition, the invention also provides the preparation method of the injection cefoperazone sodium and sulbactam sodium pharmaceutical composition. The injection cefoperazone sodium and sulbactam sodium pharmaceutical composition provided herein has the advantages such as high dissolution speed, low content of related matters, stable product quality, low adverse effect and good clinical application safety.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a compound pharmaceutical composition of cefoperazone sodium and sulbactam sodium for injection and a preparation method thereof. Background technique [0002] Cefoperazone sodium and sulbactam sodium for injection is a third-generation cephalosporin, a compound preparation composed of cefoperazone sodium and sulbactam sodium. Sulbactam is a broad-spectrum enzyme inhibitor and has weak antibacterial activity against Staphylococcus aureus and most The β-lactamase produced by negative bacilli has a strong and irreversible inhibitory effect, but it is inactive to some negative chromosome-mediated β-lactamases. Cefoperazone is a third-generation cephalosporin, which has poor stability to β-lactamase. The combination of the two not only shows obvious synergistic antibacterial activity against negative bacilli, but the combined antibacterial effect is the same as th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K47/12A61K31/546A61P31/04A61K31/43
CPCA61K9/19A61K9/0019A61K31/43A61K31/546A61K47/12A61K2300/00
Inventor 蒋晨胡昌勤周晓东
Owner 福安药业集团庆余堂制药有限公司
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