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Liposome and preparation method thereof

A liposome and system technology, which is applied in the directions of liposome delivery, pharmaceutical formulations, and non-active ingredients medical preparations, etc. problems such as poor properties, and achieve good dispersion and stability, good liposome quality, and good stability.

Inactive Publication Date: 2017-02-15
刘彦博
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing method for preparing liposomes from soybean phospholipids also has many defects
For example, in the preparation process, since phospholipids are difficult to be solvents in water, phenomena such as poor dispersibility of phospholipids, easy generation of water-soluble particles, and precipitation of viscous objects will occur; at the same time, the prepared liposomes have poor stability and must be processed under low temperature conditions. storage with a short shelf life

Method used

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  • Liposome and preparation method thereof
  • Liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The liposomes of Example 1 were prepared according to the method described below:

[0043] (1) Under the condition of 20~30℃, according to the ratio of the volume of water to the mass of phospholipid at a ratio of 100:10, add water to the phospholipid and stir and mix for 30 minutes;

[0044] (2) Introduce the mixed system obtained after stirring and mixing into a grinder, and grind for 4 to 5 minutes at 20-40°C;

[0045] (3) The mixed system obtained after grinding is introduced into a grinding machine, and the liposome of Example 1 is obtained by grinding at a temperature of 25-30° C. for 25-35 min.

[0046] At the same time, during the preparation of liposomes in Example 1, turbidity or precipitation was not found in the reaction system; after the liposomes prepared in Example 1 were placed for 60 minutes, no precipitation occurred.

Embodiment 2

[0048] The liposome of Example 2 was prepared according to the method described below:

[0049] (1) Under the condition of 20~30℃, according to the ratio of the volume of water to the mass of phospholipid at a ratio of 100:50, add water to the phospholipid and stir and mix for 30 minutes;

[0050] (2) Introduce the mixed system obtained after stirring and mixing into a grinder, and grind for 4 to 5 minutes at 20-40°C;

[0051] (3) The mixed system obtained after grinding is introduced into a grinding machine, and the liposomes of Example 2 are obtained by grinding at a temperature of 25-30° C. for 25-35 minutes.

[0052] At the same time, during the preparation of liposomes in Example 2, turbidity or precipitation was not found in the reaction system; after the liposomes prepared in Example 2 were placed for 60 minutes, no precipitation occurred.

Embodiment 3

[0054] The liposomes of Example 3 were prepared according to the method described below:

[0055] (1) Under the condition of 20~30℃, according to the ratio of the volume of water to the mass of phospholipid in grams of 100:80, add water to the phospholipid, and stir and mix for 30 minutes;

[0056] (2) Introduce the mixed system obtained after stirring and mixing into a grinder, and grind for 4 to 5 minutes at 20-40°C;

[0057] (3) The mixed system obtained after grinding is introduced into a grinding machine, and the liposomes of Example 3 are obtained by grinding at a temperature of 25-30° C. for 25-35 minutes.

[0058] At the same time, during the preparation of liposomes in Example 3, no turbidity or precipitation was found in the reaction system; after the liposomes prepared in Example 3 were placed for 60 minutes, no precipitation occurred.

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Abstract

The invention provides liposome and a preparation method thereof. According to the method provided by the invention, phospholipid and water are stirred and mixed; then, grinding and polishing are performed, so that the phospholipid can be effectively scattered in the water body, and can be mixed with the water body; further, the prepared phospholipid has high stability; in addition, the liposome can be stored for a long time at normal temperature without deterioration.

Description

Technical field [0001] The invention relates to the field of liposomes, in particular to a liposome and a preparation method thereof. Background technique [0002] Liposomes (Oiposomes) are generally composed of complex phospholipids and have a bilayer structure that mimics biological membranes. As a drug carrier, liposomes can encapsulate water-soluble and fat-soluble substances, and have outstanding characteristics such as targeting, sustained release, non-immunogenicity and easy degradation. [0003] Liposomes can be divided into unilamellar liposomes and multilamellar liposomes according to their structure and the number of phospholipid membrane layers. The unilamellar liposomes are composed of a layer of bimolecular layers. According to the different particle diameters, unilamellar liposomes can be subdivided into large unilamellar liposomes (particle size between 0.1 and 1μm) and small unilamellar liposomes. Comparticular liposomes (with a particle size of 0.02~0.08μm, also...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K47/24
CPCA61K9/1277A61K47/24
Inventor 刘彦博刘军生
Owner 刘彦博
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