High-content fomesafen aqueous solution and preparation method thereof

Abstract

The invention relates to a high-content fomesafen aqueous solution and a preparation method thereof. The preparation method comprises the following steps: adding deionized water into a container, stirring, adding a 97% fomesafen raw medicine, slowly dropping a 99% 2-(2-aminoethoxy) ethanol solution, after dropping is completed, continuously stirring for more than 10 minutes to sufficiently react and neutralize the fomesafen raw medicine with 2-(2-aminoethoxy) ethanol so as to form a transparent solution, finally adding an alkyl glycoside surfactant aid, and uniformly stirring to obtain a fomesafen aqueous solution product.

Description

technical field [0001] The invention relates to a high-content fomesafen aqueous agent and a preparation method thereof, belonging to the technical field of pesticide preparation. Background technique [0002] Fomesafen: English Common name: Fomesafen Chemical name: 5-2(2-chloro-a,a,a-trifluoro-p-tolyloxy)-N-methylsulfonyl-2-nitrobenzamide CAS NO.: 72178-02-0. [0003] Relative molecular weight: 438.8 Molecular formula: C15H10ClF3N2O6S Physical and chemical properties: The original drug is light yellow solid. Solubility: 120mg / L in water (23-25°C); 600mg / L in acetone, 500mg / L in ethanol, 50mg / L in dichloroethane, xylene, kerosene <10g / kg (25°C). Stability: Decompose at 235°C. It is stable at a temperature of 40°C and a pH of 3-9. [0004] Toxicology: The acute oral LD50 of rats is 2025mg / kg, the acute oral LD50 of female rats is 1370mg / kg, the acute oral LD50 of male mice is 2050mg / kg, and the acute oral LD50 of female mice is 1370mg / kg. The acute percutaneous LD50 o...

AI Technical Summary

Problems solved by technology

Potassium salt has the best medicinal effect, but the water solubility of potassium salt is very small, so it cannot be formulated into a high-content water solution, and the cost of raw materials for making potassium salt is very high, so potassium salt solution is generally rarely prepared

Ammonia, the raw material for making ammonium salts, is readily available and cheap, but ammonium salts and potassium salts have the same disadvantages, that is, the water solubility is too low to be formulated into high-content water preparations. Generally, ammonium salts are only used to prepare granules product

[0010] At present, there are some high-content fomesafen aqueous preparations on the market, such as 480g / l sodium saline solution, but a large amount of polar organic solvents must be added to the preparations, such as dimethylformamide, N-methylpyrrolidone, etc. To inhibit the precipitation of active ingredients in the preparation at low temperature, although it is an environmentally friendly water formulation in name, the solvent used in it is not environmentally friendly, very unfriendly to the environment, and there is a great environmental risk

There are other high-content fomesafen aqueous products, although the content is as high as 400~500g / l, but it is actually just a kind of mother liquor, which lacks the essential surfactant in pesticide preparation products, and the product must be used In addition, add a surfactant, otherwise the efficacy will be extremely poor

Although this product has increased the content of the product and saved a small amount of packaging costs, it has increased the usage of the mu product at the expense of the performance of the drug, and increased the cost of use for consumers in a disguised form.

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