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Injection composition containing coenzyme Q10 and preparation method of injection composition

A technology for injections and compositions, applied in the field of injection compositions containing coenzyme Q10 and its preparation, can solve the problem that the DNA repair mechanism is not as good as nuclear DNA, etc.

Inactive Publication Date: 2017-02-08
温迪熊(上海)儿童用品股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reason may be that the DNA in the mitochondrial matrix is ​​more accessible to endogenous oxygen free radicals, and the DNA repair mechanism in the mitochondria is far inferior to nuclear DNA

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Raw materials (parts by weight) of the injection composition containing coenzyme Q10: 103 parts of reduced coenzyme Q, 6.2 parts of glycerin, 10 parts of hydroxypropyl methylcellulose, 6 parts of cosolvent, 0.21 parts of stabilizer, and 74 parts of deionized water.

[0030] The co-solvent is obtained by stirring and uniformly mixing alanine, arginine and mannitol in a mass ratio of 1:1:1.

[0031] The stabilizer is obtained by stirring and uniformly mixing sodium citrate, sodium dihydrogen phosphate and sodium bisulfite in a mass ratio of 1:1:1.

[0032] The preparation method of the above-mentioned injection composition containing coenzyme Q10 may further comprise the steps:

[0033] Add reduced coenzyme Q10, glycerol, hydroxypropyl methylcellulose, cosolvent, stabilizer, and deionized water to a high-pressure homogenizer (the model provided by Shanghai Taichi Light Industry Equipment Co., Ltd. is GJJ-0.1 / 100 The biopharmaceutical high-pressure homogenizer) was heated...

Embodiment 2

[0035] It is basically the same as in Example 1, except that the co-solvent is obtained by stirring and mixing uniformly alanine and arginine at a mass ratio of 1:1. Obtain the injection composition containing coenzyme Q10 of embodiment 2.

Embodiment 3

[0037] It is basically the same as in Example 1, except that the co-solvent is obtained by arginine and mannitol in a mass ratio of 1:1 and uniformly stirred and mixed. Obtain the injection composition containing coenzyme Q10 of embodiment 3.

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Abstract

The invention discloses an injection composition containing coenzyme Q10 and a preparation method of the injection composition. The injection composition containing the coenzyme Q10 is prepared from the following raw materials in parts by weight: 1 to 10 parts of the reduced coenzyme Q10, 5 to 15 parts of glycerinum, 5 to 15 parts of hydroxypropyl methyl cellulose, 5 to 15 parts of a cosolvent, 0.2 to 2 parts of a stabilizer and 65 to 85 parts of water. According to the injection composition containing the coenzyme Q10, disclosed by the invention, regenerated energy can be injected into skin directly, the injection composition is resistant to oxidation, and the injection composition has active synergism on esophageal tube perfusion therapy for muscular dystrophy, hearing disturbance, neurogenic cystitis, cardiac valve replacement, coronary artery bypass graft, heart transplantation and the like.

Description

technical field [0001] The invention relates to the technical field of injections, in particular to an injection composition containing coenzyme Q10 and a preparation method thereof. Background technique [0002] Since coenzyme Q10 was discovered by scientists in the middle of the last century and its chemical structure was confirmed, its important role in human physiology and life processes has been gradually recognized by us. [0003] Coenzyme Q10, also known as ubiquinone 10, is a fat-soluble quinone. It is an orange-yellow crystal at room temperature, with a melting point of 48°C. It is odorless and tasteless. Its structure is similar to vitamin K. Polyisoprenyl is named after its degree of polymerization is 10) is a quinone compound. Another form of it is a reduced coenzyme, and its physiological functions are mainly derived from the redox properties of the quinone group and the physical properties of the isoprenoid side chain. [0004] With the deepening of human lif...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/675A61K47/38A61K47/10A61P39/06A61P21/00A61P27/16A61P13/10A61P9/00
CPCA61K31/675A61K9/0019A61K9/08A61K47/10A61K47/38
Inventor 张启明张莉
Owner 温迪熊(上海)儿童用品股份有限公司
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