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Intraocular lens for preventing and treating after cataract, and preparation method thereof

A technology of phototherapy and matrix materials, applied in prosthetics, medical science, etc., can solve problems such as not being able to prevent post-failure well

Inactive Publication Date: 2017-02-01
EYEBRIGHT MEDICAL TECH BEIJING +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Therefore, the prior art can not prevent the occurrence of after-disorder well, and there is no effective method to prevent and treat after-disorder in clinical practice at present.

Method used

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  • Intraocular lens for preventing and treating after cataract, and preparation method thereof
  • Intraocular lens for preventing and treating after cataract, and preparation method thereof
  • Intraocular lens for preventing and treating after cataract, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Example 1: Preparation of hydrophobic acrylate intraocular lens

Embodiment 1a

[0096] Step 1: In a 250ml beaker, add 55.0 g butyl acrylate monomer (BA), 40.0 g methyl methacrylate (MMA), 4.5 g butylene glycol dimethacrylate (BDDMA), and 0.25 g initiator (Azobisisobutyronitrile, AIBN), 0.20 g ultraviolet absorber (UVAM), 0.02 g photosensitizer (purpurin 18), after fully stirring, transfer to the forming mold. After injecting nitrogen gas into the monomer solution, seal the mold, put it in a water bath at 65°C for 24 hours of polymerization reaction, and then transfer the mold to an oven at 90°C for 24 hours to obtain a photosensitive compound containing purpurin 18. agent of methyl methacrylate and butyl acrylate copolymer materials. Methyl methacrylate is a hard segment monomer, butyl acrylate is a soft segment monomer, and the two can be copolymerized to obtain a foldable intraocular lens material. The molecular structural formula of purpurin 18 is shown below. Since its molecular structural formula contains ethylenically unsaturated double bonds, it c...

Embodiment 1a-1n

[0100] Reaction condition is substantially identical with embodiment 1a, difference is as follows:

[0101] monomer combination Photosensitizer 1a MMA+BA+BDDMA Purpurin 18 1b EA+EMA+EGDMA Pheophorbide a 1c MMA+EGDMA Chlorin e4 1d EA+EMA+HFIPMA+EGDMA Chlorin e6 1e PEA+PEMA+BDDMA Chlorin p6 1f EA+St+EGDMA Chlorin f 1g EA+MSt+HDDMA Methyl pheophorbide a 1h POEA+BMA+EGDMA Purpurin 18 methyl ester 1i POEA+EMA+BDDMA Chlorin e4 dimethyl ester 1j POEA+BA+St+EGDMA Chlorin e6 trimethyl ester 1k EA+EOEMA+HDDMA Chlorin p6 trimethyl ester 1l EA+EMA+EOEOEMA+BDDMA Chlorin f dimethyl ester 1m POEA+EGDMA Protoporphyrin 1n St+DVB Protoporphyrin dimethyl ester

[0102] MMA: methyl methacrylate

[0103] EA: ethyl acrylate

[0104] EMA: ethyl methacrylate

[0105] BA: butyl acrylate

[0106] EGDMA: Ethylene glycol dimethacrylate

[0107] BDDMA: Butylene glycol dimeth...

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PUM

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Abstract

The present invention relates to medical devices, particularly to an intraocular lens and a preparation method thereof, more particularly to a medical device for light therapy, specifically to an intraocular lens for preventing and / or treating after cataract, and a preparation method thereof.

Description

technical field [0001] The present invention relates to a medical device, especially an intraocular lens and a method for its preparation, more particularly, the present invention relates to a medical device for phototherapy, in particular, an intraocular lens for the prevention and / or treatment of post-cataract and its preparation method. Background technique [0002] In the existing technology, laser-driven phototherapy can be used to treat some diseases. Laser-driven phototherapy has achieved remarkable results in tumor treatment. The field of ophthalmology is also receiving increasing attention. The phototherapy in the prior art activates the photodynamic effect or photothermal effect of nanomaterials through the near-infrared light penetrating the skin to act on the tumor site, so as to kill tumor cells. According to the different mechanism of action after the laser irradiates the material, it can be divided into photodynamic therapy and photothermal therapy. [0003...

Claims

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Application Information

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IPC IPC(8): A61L27/54
Inventor 解江冰王浩朱思泉隋信策王磊魏永吉赵阳
Owner EYEBRIGHT MEDICAL TECH BEIJING
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