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A kind of hydrogel with micro-current and sustained drug release, its preparation method and application

A micro-current and hydrogel technology, applied in electrotherapy, magnetic field generated by permanent magnets, magnetic therapy, etc., can solve the problem of drug slow release ability and healing promotion ability, poor mechanical properties of hydrogel, wound surface No protective effect and other problems, to achieve good electron transport ability, improve mechanical properties, and enrich the effect of surface defects

Active Publication Date: 2019-07-26
广东省科学院生物与医学工程研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, few studies have applied carbon quantum dots to chronic wounds
[0004] Chinese patent CN104177541A discloses a carbon quantum dot / polyacrylamide fluorescent hydrogel, but the hydrogel prepared by this method is a single network structure with poor mechanical properties and low strength
Chinese patent CN105504364A discloses a high-strength fluorescent hydrogel and its preparation method. The hydrogel not only has high strength, but also has excellent fluorescent tracer function, but its drug slow-release ability and healing-promoting ability are not found in the patent. illustrate
[0005] Growth factors have the function of promoting the healing of wounds and ulcers, and can be used in the treatment of wounds, burns, ulcers and other diseases. However, growth factors are mostly administered with water or spray, which requires many dressing changes, short stay time on the wound surface, and no protection for the wound surface. The effect and curative effect are not obvious, and the clinical use is greatly limited

Method used

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  • A kind of hydrogel with micro-current and sustained drug release, its preparation method and application
  • A kind of hydrogel with micro-current and sustained drug release, its preparation method and application
  • A kind of hydrogel with micro-current and sustained drug release, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A hydrogel with micro-current and drug sustained release, the specific preparation method is as follows:

[0050] (1) Dissolve 0.5g epidermal growth factor in 50mL deionized water, add 25g carbon quantum dots, stir magnetically at 30°C and 40rpm for 1h, centrifuge the product at 4000rpm for 10min, discard the supernatant, and The residue was washed successively with ethanol and deionized water, repeated three times, and finally freeze-dried for 24 hours to obtain drug-loaded carbon quantum dots.

[0051] (2) Dissolve 1g of sodium alginate powder and 1g of sodium carboxymethylcellulose powder in 100mL of deionized water respectively. After dissolving, add 1g of polyvinylidene fluoride powder and 1g of permanent magnet nano Granules (magnetic field strength is 0.15 tesla), 1g of drug-loaded carbon quantum dots obtained in step (1) and 3g of anhydrous calcium carbonate powder, after stirring evenly, add carboxymethylcellulose sodium solution.

[0052] (3) Add 6g of glucon...

Embodiment 2

[0054] A hydrogel with micro-current and drug sustained release, the specific preparation method is as follows:

[0055] (1) Dissolve 0.5g of epidermal growth factor in 50mL of deionized water, then add 15g of carbon quantum dots, stir magnetically at 37°C and 40rpm for 2h, centrifuge the product at 4000rpm for 10min, and use ethanol, deionized Water was washed sequentially, repeated 3 times, and finally freeze-dried for 24 hours to obtain drug-loaded carbon quantum dots.

[0056] (2) Dissolve 1.5g of sodium alginate powder and 1.5g of sodium carboxymethylcellulose powder in 100mL of deionized water respectively. After dissolving, add 1.2g of polyvinylidene fluoride powder, 4.8 g permanent magnet nanoparticles (magnetic field strength is 0.25 tesla), 1.5 g of drug-loaded carbon quantum dots obtained in step (1) and 6 g of anhydrous calcium carbonate powder, after stirring evenly, add carboxymethyl cellulose sodium solution.

[0057] (3) Finally, add 12g of gluconolactone, sti...

Embodiment 3

[0059] A hydrogel with micro-current and drug sustained release, the specific preparation method is as follows:

[0060] (1) Dissolve 0.5g of epidermal growth factor in 50mL of deionized water, then add 2.5g of carbon quantum dots, stir magnetically at 45°C and 40rpm for 3h, centrifuge the product at 4000rpm for 10min, and use ethanol, deionized Ionized water was washed sequentially, repeated 3 times, and finally freeze-dried for 24 hours to obtain drug-loaded carbon quantum dots.

[0061] (2) Dissolve 2g of sodium alginate powder and 2g of sodium carboxymethyl cellulose powder in 100mL of deionized water respectively. After dissolving, add 1.67g of polyvinylidene fluoride powder, 8.33g of yam Magnet nanoparticles (the particle magnetic field strength is 0.35 Tesla), 2g of the drug-loaded carbon quantum dots obtained in step (1) and 10g of anhydrous calcium carbonate powder are stirred evenly, and then sodium carboxymethylcellulose solution is added.

[0062] (3) Finally, 20 ...

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Abstract

The invention discloses hydrogel with microcurrent and a medicine slow-release function and a preparation method and application. The preparation method comprises the following steps: carrying out reaction on a medicine and a carbon quantum dot so as to obtain a medicine-carried carbon quantum dot; uniformly mixing a sodium alginate solution, a sodium carboxymethyl cellulose solution, a power generation substance, the medicine-carried carbon quantum dot and anhydrous calcium carbonate powder so as to obtain mixed liquid A; adding glucose lactone into the mixed liquid A, uniformly stirring, performing ultrasonic defoaming, leveling, and drying, thereby obtaining the hydrogel with the microcurrent and the medicine slow-release function. The hydrogel has the advantages of excellent mechanical property, very good medicine slow-release property, very good heal promotion effects, very good swelling property, very good biological security and large market application prospect.

Description

technical field [0001] The invention belongs to the field of medical dressings, and in particular relates to a hydrogel with micro-current and drug slow-release effects, a preparation method and application. Background technique [0002] Hydrogels are polymeric materials that can swell in water and hold large amounts of water without dissolving. Sodium carboxymethyl cellulose is a water-soluble cellulose ether with good biocompatibility and biodegradability, and is widely used in the fields of medicine, food and daily chemicals. The molecular structure of sodium carboxymethyl cellulose contains a large number of carboxyl groups and hydroxyl groups, which has good hydrophilicity. Sodium alginate is a non-toxic natural polysaccharide macromolecule extracted from brown algae kelp or sargassum. Under certain conditions, it can form a hydrogel with good adsorption performance and mild gelation conditions. It is suitable as a drug carrier. Using sodium alginate and sodium carbo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00A61N1/00A61N2/08C08J3/075
CPCA61L26/0004A61L26/0014A61L26/0023A61L26/0061A61L26/0066A61L26/008A61L26/0085A61L26/009A61L2300/102A61L2300/412A61L2300/414A61L2300/604A61N1/00A61N2/002A61N2/06C08J3/075C08J2301/28C08J2305/04C08J2327/16C08J2427/16C08L27/16
Inventor 马年方梁磊李锦荣曾建郭剑雄李昱
Owner 广东省科学院生物与医学工程研究所
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