Nalmefene hydrochloride nasal medicine administration preparation

Abstract

The invention provides a nalmefene nasal medicine administration preparation, which is prepared from nalmefene hydrochloride, nalmefene free alkali or pharmaceutically acceptable other nalmefene pharmaceutical salts and sorbefacients. A great number of experiments show that the nasal medicine administration preparation provided by the invention realizes the medicine absorption through a tunica mucosa nasi path, and the medicine enters blood circulation to achieve the effect; the advantages of stable performance, quality controllability and no stimulation on the tunica mucosa nasi can be realized. The nasal medicine administration preparation provided by the invention belongs to the intranasal medicine administration preparation capable of being used for shock resistance, overdose anesthesia rescue in an operation, morphine medicine poisoning and drug dependence person diagnosis, and prevention or treatment on stress diseases of acute alcoholism, cerebral infarction, neonatal asphyxia, drug poisoning and the like.

Description

technical field [0001] The invention relates to a preparation for nasal cavity administration, in particular to a preparation for nasal cavity administration of nalmefene hydrochloride. Background technique [0002] Nalmefene hydrochloride (nalmefene hydrochloride) is an opioid antagonist, created by the American Ivax / Ohmeda company, and listed in the United States in 1995. It is another new pure opioid receptor antagonist synthesized after naloxone (NALOXONE) and naltrexone (Naltrexone). It can bind to opioid receptors μ, κ, and δ, and has the strongest binding effect on μ receptors. [0003] Nalmefene hydrochloride is a pure opioid receptor antagonist and a derivative of water-soluble naltrexone. Its 6-methylene chemical structure makes it exhibit stronger physiological activity and easier penetration of biological membranes. Its plasma elimination half-life (t 1 / 2 ) is 8.2-8.9h, and similar compound naltrexone (F=5%-20%, t 1 / 2 =2-5h) and naltrexone (F=0%-5%, t 1 / 2 =1...

AI Technical Summary

Problems solved by technology

[0005] Practice has also proved that although the nalmefene hydrochloride injection and oral preparations used clinically have a certain therapeutic effect, the onset of effect is slow, and the onset of effect is 30 minutes after administration. max 1.5 hours or more

However, intravenous and intramuscular injections must be operated by professional medical personnel.