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Method for preparing medicinal transdermal material

A technology of transdermal and preparation steps, which is applied in the field of preparation of medicinal transdermal materials, which can solve the problems of secondary infection of wounds, adhesive wounds, poor permeability, etc., and achieve comfortable application, good affinity, and large drug loading capacity. Effect

Inactive Publication Date: 2017-01-18
CHANGZHOU YAHUAN ENVIRONMENTAL PROTECTION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem mainly solved by the present invention: Aiming at the defects that the traditional transdermal materials have poor permeability, low drug loading capacity, and absorbing the pollution of wound exudate will cause the secondary infection of the wound, and the wound will stick to the wound when it is removed, the present invention After mixing the urine of a lactating baby with sodium hydroxide, the supernatant was reacted with ammonium sulfate and centrifuged to obtain the lower precipitate, which was dissolved and then eluted with an elution column. The eluate was collected, spray-dried and set aside for later use Heat degumming of silk and sodium carbonate, add calcium chloride and stir and dialyze with double distilled water, mix the supernatant after centrifugation with sodium alginate, calcium carbonate, etc. to obtain a gel, then stir with spare dry solids, etc. The medicinal transdermal material is obtained. The transdermal material obtained in the present invention has strong transdermal effect, good air permeability, closer affinity with the skin, can efficiently penetrate the stratum corneum of the skin, reduce the dosage of drugs, moderate drug loading, and target The effect is more significant, no irritation to the skin, no allergic reaction, comfortable to use and can be peeled off repeatedly, and has a broad application prospect

Method used

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Examples

Experimental program
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Effect test

example 1

[0017] First, take 300mL of the urine of a lactating baby and add it to the beaker, then add 20% sodium hydroxide solution to adjust the pH to 7.2, let it stand for 1 hour, draw 100mL of the supernatant with a syringe, add it to the beaker, and add it while stirring 30g of ammonium sulfate was then placed in a centrifuge, centrifuged at 3000r / min for 20min, and the lower precipitate was collected; the above lower precipitate was added to a beaker, and 100mL of deionized water was added, stirred for 20min, and dissolved to obtain a solution. The solution was added to a diethylaminoethyl cellulose column, eluted with 100mL mass fraction of 30% ammonium chloride as a solvent, collected the eluate, and placed in a spray dryer to spray dry to obtain a solid, which was used for subsequent use; Take 20g of silk and add it to a beaker, then add 400mL of 10% sodium carbonate solution by mass fraction, heat to boiling, keep warm for 1h, filter to obtain degummed silk, and add it to the b...

example 2

[0020]First, take 400mL of lactating infant urine and add it to the beaker, then add 20% sodium hydroxide solution to adjust the pH to 7.4, let it stand for 2 hours, draw 200mL of the supernatant with a syringe, add it to the beaker, and add it while stirring 35g of ammonium sulfate was then placed in a centrifuge, centrifuged at 4000r / min for 30min, and the lower precipitate was collected; the above lower precipitate was added to a beaker, and then 200mL of deionized water was added, stirred for 30min, and dissolved to obtain a solution. The solution was added to a diethylaminoethyl cellulose column, eluted with 200mL mass fraction of 30% ammonium chloride as a solvent, collected the eluate, and placed in a spray dryer to spray dry to obtain a solid, which was used for subsequent use; Take 30g of silk and put it into a beaker, then add 500mL of 10% sodium carbonate solution by mass fraction, heat to boiling, keep warm for 2h, filter to obtain degummed silk, and add it to the b...

example 3

[0023] First, take 350mL of the urine of a lactating baby and add it to a beaker, then add 20% sodium hydroxide solution to adjust the pH to 7.3, let it stand for 1.5h, draw 150mL of the supernatant with a syringe, add it to the beaker, and stir Add 40g of ammonium sulfate, then place it in a centrifuge, centrifuge at 3500r / min for 25min, and collect the lower precipitate; add the above lower precipitate into a beaker, then add 150mL of deionized water, stir for 25min, and dissolve it to obtain a solution. Add the solution to a diethylaminoethyl cellulose column, elute with 150 mL of ammonium chloride with a mass fraction of 30% as a solvent, collect the eluate, and spray dry it in a spray dryer to obtain a solid for subsequent use; Weigh 25g of silk and add it to a beaker, then add 450mL of 10% sodium carbonate solution, heat to boiling, keep warm for 1.5h, filter to obtain degummed silk, and add it to the beaker, then add 250mL of 30% sodium carbonate solution Calcium chlori...

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Abstract

The invention discloses a method for preparing a medicinal transdermal material and belongs to the technical field of medicine external application preparations. After lactation period infant urine and sodium hydroxide are mixed, supernatant liquid is taken to undergo reaction and centrifugation together with ammonium sulfate and then lower layer sediment is obtained, the sediment is dissolved and eluted and then eluent is collected, the eluent undergoes spray drying for standby application, silk and sodium carbonate are taken and heated to perform degumming, calcium chloride is added and double distilled water is used to perform stirring and dialysis, centrifuged supernatant, sodium alginate and calcium carbonate and the like are mixed to obtain gel, the gel and standby dry solid and the like are stirred, and a membrane is manufactured and dried, so that the medicinal transdermal material is obtained. The medicinal transdermal material is high in transdermal effect and good in breathability, closer in affinity with the skin and can very efficiently penetrate cuticle of the skin, a medicine dosage is reduced, the medicine loading capacity is moderate, a targeting effect is remarkable, and the medicinal transdermal material has no stimulation to the skin, has no anaphylaxis, is pasted comfortably and can be pasted and removed repeatedly and has wide application prospect.

Description

technical field [0001] The invention discloses a preparation method of a medicinal transdermal material, which belongs to the technical field of pharmaceutical preparations for external use. Background technique [0002] In recent years, with the development of science and technology, the gradual improvement of medical level, people's understanding of the process of wound care and the understanding of the principle of wound healing, more and more natural polymer materials with special properties have been used in the production and production of medical dressings. in use. At present, the main function of medical dressings is still as a covering material for wounds. At the same time, it is necessary to absorb wound exudate and prevent the wound from being polluted by bacteria and dust particles. There are many types of medical dressings, and the most common one is traditional gauze, which is widely used. However, gauze dressings have a fatal weakness that they are easy to s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/46A61K47/42A61K47/36
CPCA61K9/7023A61K47/36A61K47/42A61K47/46
Inventor 高玉梅孟中立陆娜
Owner CHANGZHOU YAHUAN ENVIRONMENTAL PROTECTION TECH
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