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Omidazole injection

A technique for ornidazole injection and ornidazole, which is applied in the field of supersaturated ornidazole injection, can solve problems such as difficulty in accurate use by clinicians, unfavorable operation, etc., and achieves low nitrite content and compatibility stability. Good results

Inactive Publication Date: 2017-01-11
BEIJING JINGKE TAILAI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the composition with the lowest organic solvent is 1g of ornidazole, 1g of propylene glycol, and 2g of ethanol. This solution reduces the amount of organic solvent used by about 1 / 3, and the volume of the drug solution is about 4.3ml. It is difficult for clinicians to use it accurately.
Secondly, this preparation method needs to go through two heating and cooling cycles in the preparation process, which is not conducive to the operation during production.

Method used

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  • Omidazole injection
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] prescription:

[0024] Element Dosage Ornidazole 1kg Propylene Glycol 0.7kg Absolute ethanol Add to 4L

[0025] Weigh, the total amount is 3.69kg.

[0026] Preparation:

[0027] (1) ornidazole is mixed with propylene glycol and dehydrated alcohol;

[0028] (2) Heating the uniformly mixed material to 30-40°C;

[0029] (3) 0.22μm membrane filtration sterilization, potting, the specification is 4ml;

[0030] (4) Sterilize at 122°C for 12 minutes.

Embodiment 2

[0032] prescription:

[0033] Element Dosage Ornidazole 1kg Propylene Glycol 0.78kg Absolute ethanol Add to 4L

[0034] Weigh, the total amount is 3.73kg.

[0035] Preparation:

[0036] (1) ornidazole is mixed with propylene glycol and dehydrated alcohol;

[0037] (2) Heating the uniformly mixed material to 30-40°C;

[0038] (3) 0.22μm membrane filtration sterilization, potting, the specification is 4ml;

[0039] (4) Sterilize at 122°C for 12 minutes.

Embodiment 3

[0041] prescription:

[0042] Element Dosage Ornidazole 1kg Propylene Glycol 0.91kg Absolute ethanol Add to 4L

[0043] Weigh, the total amount is 3.75kg.

[0044] Preparation:

[0045] (1) ornidazole is mixed with propylene glycol and dehydrated alcohol;

[0046] (2) Heating the uniformly mixed material to 30-40°C;

[0047] (3) 0.22μm membrane filtration sterilization, potting, the specification is 4ml;

[0048] (4) Sterilize at 122°C for 12 minutes.

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PUM

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Abstract

The invention provides an over-saturated omidazole injection which comprises 1 g of omidazole, 0.7-1.1 g of propylene glycol and alcohol added to 4ml. Content of propylene glycol is 0.7-1.02g preferably, 0.78-0.91g further preferably and 0.78g optimally. The over-saturated omidazole injection is high in combining stability and low in content of nitrite in the process of storage.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a supersaturated ornidazole injection. Background technique [0002] Ornidazole, namely 1-(3-chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole, belongs to the third generation of nitroimidazole antibacterial drugs, and its mechanism of action is through the nitroimidazole in its molecule. In an anaerobic environment, it is reduced to amino groups or through the formation of free radicals, and interacts with cell components, resulting in the death of microorganisms. Therefore, it has a strong effect on diseases caused by anaerobic bacteria, trichomonas, amoeba, etc. Therapeutic effect. [0003] Ornidazole injection is widely used in clinical practice, and it is the drug of choice for the treatment of anaerobic infection, and it also has a certain inhibitory effect on some aerobic bacteria. It can be used to prevent infection before surgery and treat anaerobic infection...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4164A61K47/10A61P31/04A61P33/02A61P31/00
CPCA61K9/0019A61K9/08A61K31/4164A61K47/10
Inventor 不公告发明人
Owner BEIJING JINGKE TAILAI TECH
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