Vitacoenzyme composition, hard capsules containing same and preparation method of hard capsules

A technology of vizyme and composition, which is applied in the field of medicine, can solve the problems of granules sticking to the net, granules not entering the capsule mold, affecting the quality of medicines, etc., to achieve the effect of ensuring effectiveness and moderate granule viscosity

Inactive Publication Date: 2017-01-04
华夏国药(菏泽)制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this formula has the following problems in the process of preparing capsule granules: 1. The granulation process is difficult to granulate, and the granules stick to the net severely, causing the sieve to often break during the granulation process, and the broken sieve wires are mixed into the medicine, seriously The quality of the medicine is affected; ②Due to the light weight of the granules in the capsule filling process, the granules often do not enter the capsule mold; ③The capsules made by the capsule absorb moisture seriously, and the quality control of the finished product is seriously affected

Method used

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  • Vitacoenzyme composition, hard capsules containing same and preparation method of hard capsules
  • Vitacoenzyme composition, hard capsules containing same and preparation method of hard capsules

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Effect test

Embodiment 1

[0019] 1) Weigh 80kg of vizyme, 6kg of calcium carbonate, 9kg of sucrose, 2kg of starch, 1kg of hydroxypropyl cellulose, 1kg of dextrin, and povidone K 30 0.5kg, 0.5kg of micropowder silica gel, 2kg of beeswax, and 1.2kg of grape seed oil for standby;

[0020] 2) Mix vizyme, calcium carbonate, sucrose and starch evenly, then heat and dissolve grape seed oil and beeswax to obtain a liquid oil wax liquid, and add the mixture of vizyme, calcium carbonate, sucrose and starch while maintaining the temperature In liquid oil wax liquid, after stirring for about 1 hour;

[0021] 3) Then add hydroxypropyl cellulose, dextrin, povidone K 30 and micropowder silica gel, continue to stir for about 1 hour, then cool to room temperature;

[0022] 4) Then use a 16-mesh sieve to make granules, dry at 65°C, and then use a 14-mesh sieve to size the granules. The sized granules and capsule liquid pass through an automatic capsule filling machine to make hard capsules. During the preparation pro...

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Abstract

The invention relates to the technical field of medicine, in particular to vitacoenzyme composition, hard capsules containing same and a preparation method of the hard capsules. The vitacoenzyme composition comprises vitacoenzyme, calcium carbonate, sucrose, starch, hydroxypropyl cellulose, dextrin, povidone K30, aerosil, beeswax and grape seed oil. According to the vitacoenzyme composition, the effectiveness of the vitacoenzyme ingredient is guaranteed, beeswax, grape seed oil and other ingredients are added to the components, so that granules have mediate viscosity, cannot break when passing a screen and cannot damage the scree due to hanging, and the granules can be put into a bag mold conveniently.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a visin composition, a hard capsule containing the composition and a preparation method thereof. Background technique [0002] Vizyme uses soybean as the main raw material and is refined and processed by biological fermentation. Its main components are riboflavin and riboflavin derivatives. Among them, there are 12 kinds of vitamins, B2 and VE are the most, 18 kinds of amino acids, and trace amounts There are 23 kinds of elements, and others include sugar, crude fiber, etc. Clinically, Vizyme capsules or tablets are mainly used for atrophic gastritis, and can also be used for esophageal epithelial hyperplasia and other diseases. [0003] At present, vizyme capsules often use vizyme, talcum powder, magnesium stearate, and starch as raw materials, and use purified water as a wetting agent to stir them into soft materials, then sieve them into granules, and dry them Finally, it i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61K9/48A61K47/44A61P1/04A61P1/00
CPCA61K36/48A61K9/4858
Inventor 陈长印马朝霞王星星
Owner 华夏国药(菏泽)制药有限公司
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