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Method for simultaneous detection of 22 kinds of polycyclic aromatic hydrocarbons in cigarette smoke

A technology for polycyclic aromatic hydrocarbons and substance content, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of low sensitivity and selectivity, tedious and time-consuming pretreatment, and high consumption of organic solvents, and achieve high sensitivity and sample pretreatment Convenience and pollution reduction effect

Active Publication Date: 2019-05-31
YUNNAN TOBACCO QUALITY SUPERVISION MONITORING STATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method faces the shortcomings of cumbersome and time-consuming pretreatment, high consumption of organic solvents, low sensitivity and selectivity, and serious matrix interference.

Method used

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  • Method for simultaneous detection of 22 kinds of polycyclic aromatic hydrocarbons in cigarette smoke
  • Method for simultaneous detection of 22 kinds of polycyclic aromatic hydrocarbons in cigarette smoke
  • Method for simultaneous detection of 22 kinds of polycyclic aromatic hydrocarbons in cigarette smoke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Select a cigarette as sample A, balance and extract the cigarette sample to be tested, and use a rotary smoking machine according to the standard conditions required by GB / T 19609-2004 "Determination of Total Particulate Matter and Tar by Smoking Machine for Routine Analysis of Cigarettes" Smoking, 20 cigarettes per sample.

[0048] The total particulate matter in mainstream cigarette smoke is captured by the Cambridge filter; the Cambridge filter is placed in a 250mL ground-mouth Erlenmeyer flask, and the mixture containing deuterated naphthalene (320ng / mL) and deuterated benzo[a]pyrene is added (320ng / mL) cyclohexane solution 1mL as the internal standard solution, then add 40mL cyclohexane as the extractant; shake and extract the conical flask at room temperature for 40min, pass the extract through a 0.22μm nylon 66 filter membrane, collect The filtrate was stored in a chromatographic vial for GC-MS / MS analysis.

[0049] GC-MS / MS analysis conditions:

[0050] Chromato...

Embodiment 2

[0071] Repeat Example 1, with the following differences:

[0072] Select a cigarette as sample B, balance and extract the cigarette sample to be tested, and use a linear smoking machine according to the standard conditions required by GB / T 19609-2004 "Determination of Total Particulate Matter and Tar by Smoking Machine for Routine Analysis of Cigarettes" Smoking, 20 cigarettes per sample.

[0073] The total particulate matter in mainstream cigarette smoke is captured by the Cambridge filter; the Cambridge filter is placed in a 250mL ground-mouth Erlenmeyer flask, and the mixture containing deuterated benzo[a]anthracene (200ng / mL) and deuterated phenanthrene is added (200ng / mL) methanol solution 0.5mL as the internal standard solution, then add 20mL methanol as the extractant; shake the conical flask at room temperature and extract for 60min, pass the extract through a 0.22μm polyethersulfone (PES) filter membrane, Collect the filtrate in a chromatographic vial for analysis by...

Embodiment 3

[0080] Repeat Example 1, with the following differences:

[0081] Select a cigarette as sample C, balance and extract the cigarette sample to be tested, and use a rotary smoking machine according to the standard conditions required by GB / T 19609-2004 "Determination of Total Particulate Matter and Tar by Smoking Machine for Routine Analysis of Cigarettes" Smoking, 20 cigarettes per sample.

[0082] Collect the total particulate matter of mainstream cigarette smoke through the Cambridge filter; place the Cambridge filter in a 250mL ground-mouth Erlenmeyer flask, and add a dichloromethane solution containing deuterated benzo[a]pyrene (400ng / mL) 2mL was used as the internal standard solution, and then 100mL of dichloromethane was added as the extractant; after shaking and extracting the conical flask at room temperature for 60min, the extract was passed through a 0.45μm nylon 66 filter membrane, and the filtrate was collected in a chromatographic bottle for GC-MS / MS analysis.

...

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Abstract

The invention discloses a method for simultaneously detecting content of 22 polycyclic aromatic hydrocarbon matters in cigarette smoke. The method comprises the following steps: trapping total particular matters in cigarette main stream smoke by adopting a filter; extracting the trapping filter by utilizing an extraction agent; and detecting the filtered extract liquor by adopting gas chromatography-tandem mass spectrum (GC-MS / MS), and simultaneously detecting the contents of 22 polycyclic aromatic hydrocarbon matters, including indene, naphthalene, 1-methylnaphthalene, 2-methylnaphthalene, acenaphthylene, acenaphthene, fluorene, phenanthrene, anthracene, fluoranthene, pyrene, benzo [a] anthracene, chrysene, benzo [b] fluoranthene, benzo [k] fluoranthene, benzo [j] fluoranthene, benzo [e] pyrene, benzo [a] pyrene, perylene, indene [1,2,3-cd] perylene, dibenzo [a, h] anthracene, benzo [g, h, i] pyrene, and the like, in cigarette main stream smoke. The method fills the blank of the prior art, has the characteristics of simple, convenient and quick sample pretreatment, high detection accuracy and repeatability and large analysis test flux and is fit for quick analysis of mass samples.

Description

technical field [0001] The invention belongs to the technical field of cigarette smoke analysis and detection, and specifically relates to a method capable of simultaneously detecting 22 kinds of polycyclic aromatic hydrocarbons in cigarette mainstream smoke, including: indene, naphthalene, 1-methylnaphthalene, 2-methylnaphthalene, Acenaphthylene, acenaphthene, fluorene, phenanthrene, anthracene, fluoranthene, pyrene, benzo[a]anthracene, chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[j]fluoranthene, benzene Content of a[e]pyrene, benzo[a]pyrene, perylene, indeno[1,2,3-cd]pyrene, dibenzo[a,h]anthracene, benzo[g,h,i]pyrene Methods. technical background [0002] Polycyclic Aromatic Hydrocarbons (PAHs) are a class of organic substances commonly found in mainstream cigarette smoke. They are released into the smoke along with the incomplete combustion and thermal cracking of organic substances. damage to the health of the body. PAHs can cause oxidative stress and D...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 蔡洁云李雪梅陈新瑞王惠平张庆刚刘冰王淑华李海燕马慧宇肖燕
Owner YUNNAN TOBACCO QUALITY SUPERVISION MONITORING STATION
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