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Recombinant humanized type I collagen gel scaffold for vaginal relaxation and preparation method thereof

A collagen and vaginal relaxation technology, applied in the field of medical gel, can solve problems such as lack of medicines, achieve the effects of improving sexual life satisfaction, improving vaginal relaxation symptoms, and increasing vaginal elasticity

Inactive Publication Date: 2016-12-14
易金阳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of lack of relevant drugs in the treatment of female vaginal relaxation, the present invention provides a recombinant human type I collagen gel scaffold for vaginal relaxation, which contains various components with the following mass concentrations:

Method used

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  • Recombinant humanized type I collagen gel scaffold for vaginal relaxation and preparation method thereof
  • Recombinant humanized type I collagen gel scaffold for vaginal relaxation and preparation method thereof
  • Recombinant humanized type I collagen gel scaffold for vaginal relaxation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] A recombinant human-sourced soluble high-activity type I collagen gene dressing, calculated by mass parts, the ingredients include: recombinant human-sourced soluble high-activity type I collagen 0.5%; poloxamer 407 25%; poloxamer 188 8%; Glycerin 6%; Sodium Hyaluronate 2.5%; Sodium Nepalgold Methyl Ethanate 0.02%; Phenoxyethanol 1%;

[0013] Take the preparation of 100kg gene auxiliary materials as an example, 0.5% of recombinant human-sourced soluble high-activity type I collagen, that is, 100kg dressing contains recombinant human-sourced soluble high-activity type I collagen 500g, poloxamer 407 25kg; Mu 188 8kg; glycerin 6kg; sodium hyaluronate 2.5kg; Nepal gold methyl ester sodium 20g; bacteria; add Poloxamer 407, Poloxamer 188, and glycerin to the batching tank according to the above dosage and stir intermittently for 5 minutes until uniformly dispersed; add sodium hyaluronate according to the above dosage, close the tank cover, turn on the vacuum pump, and stir H...

Embodiment 2

[0015] A recombinant human-sourced soluble high-activity type I collagen gene dressing, calculated by mass parts, the ingredients include: recombinant human-sourced soluble high-activity type I collagen 0.05%; poloxamer 407 20%; poloxamer 188 5%; Glycerin 3%; Sodium Hyaluronate 1.5%; Sodium Nepalgold Methyl Ethanate 0.05%; Phenoxyethanol 0.08%;

[0016] Take the preparation of 100kg gene auxiliary materials as an example, 0.1% of recombinant human-sourced soluble high-activity type I collagen, that is, 100kg of recombinant human-sourced soluble high-activity type I collagen, poloxamer 407 20kg; 188 5kg; glycerin 3kg; sodium hyaluronate 1.5kg; Nepal gold methyl ester sodium 50g; Sterilize; add poloxamer 407, poloxamer 188, and glycerin to the batching tank according to the above dosage and stir intermittently for 5 minutes until uniformly dispersed; add sodium hyaluronate according to the above dosage, close the tank cover, turn on the vacuum pump, and Stir and homogenize inte...

Embodiment 3

[0018] A recombinant human-sourced soluble high-activity type I collagen gene dressing, calculated by mass parts, the ingredients include: recombinant human-sourced soluble high-activity type I collagen 0.05%; poloxamer 407 15%; poloxamer 188 5%; Glycerin 3%; Sodium Hyaluronate 1.5%; Sodium Nepalgold Methyl Ethanate 0.05%; Phenoxyethanol 0.08%;

[0019] Take the preparation of 100kg gene auxiliary material as an example, 0.1% of recombinant human source soluble high activity type I collagen, that is, 100kg dressing contains recombinant human source soluble high activity type I collagen 100g, poloxamer 407 10kg; 188 5kg; glycerin 3kg; sodium hyaluronate 1.5kg; Nepal gold methyl ester sodium 50g; Sterilize; add poloxamer 407, poloxamer 188, and glycerin to the batching tank according to the above dosage and stir intermittently for 5 minutes until uniformly dispersed; add sodium hyaluronate according to the above dosage, close the tank cover, turn on the vacuum pump, and Stir an...

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Abstract

The invention relates to a recombinant humanized type I collagen gel scaffold for vaginal relaxation, as well as a preparation method and application of the recombinant humanized type I collagen gel scaffold for the vaginal relaxation. The gel scaffold comprises the following components in concentration by mass: 0.002 to 0.5% of recombinant humanized soluble high-activity type I collagen, 15 to 25% of poloxamer 407, 1 to 8% of poloxamer 188, 2 to 6% of glycerin, 0.5 to 2.5% of sodium hyaluronate, 0.02 to 2% of Nepal sodium methyl ester, 0.3 to 1% of phenoxy ethanol and the balance of deionized water. The recombinant humanized type I collagen gel scaffold for the vaginal relaxation disclosed by the invention has an obvious effect in significantly improving the vaginal relaxation, further can repair the problems of itching, scorching hot, chapping and the like caused by vaginal dryness, and further has the effects of increasing the vaginal elasticity, relieving pains during sexual intercourse, increasing the sexual satisfaction and vaginal secretions, reducing vaginal inflammatory responses, enhancing the vaginal micro environment moisture, improving the vaginal dryness and maintaining the vaginal micro environment pH. The combination is free of adverse stimulus allergic reactions and immune rejection, and can be used for being prepared into suppository dressings, gel dressings and lotions, and is worthy of being popularized clinically.

Description

technical field [0001] The invention relates to the technical field of medical gel, in particular to a recombinant human type I collagen gel scaffold for vaginal relaxation, its preparation method, and its use in improving vaginal relaxation treatment. Background technique [0002] Vagina is a muscular tube composed of mucous membrane, muscular layer and outer membrane, rich in extensibility, connecting the uterus and external genitalia. It is the sexual organ of women and the conduit for menstruation and delivery of the fetus. Vaginal relaxation is a physiological condition that occurs in women with age, and the main population is postpartum women. Severe vaginal relaxation will reduce the quality of life of couples. With the gradual change of modern people's understanding, more and more women pay attention to vaginal relaxation, and vaginal reduction products are becoming more and more popular. There are many reasons for women's vaginal relaxation in life. The most commo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/14A61L31/18A61K38/39A61K9/06A61P15/02A61P15/00
CPCA61L31/06A61K9/0034A61K9/06A61K38/39A61K47/10A61L31/042A61L31/044A61L31/145A61L31/18
Inventor 易金阳
Owner 易金阳
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