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A kind of preparation method of Shuxiong granule

A granule and chest-relaxing technology, applied in the field of traditional Chinese medicine pharmacy, can solve the problems of long drug effect cycle and incomplete extraction of active ingredients of drugs, and achieve the effects of quick effect, lower drug production cost, and economic burden.

Active Publication Date: 2020-01-24
JIANGXI JUWANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation method of the drug has defects such as incomplete extraction of the active ingredients of the drug, which leads to a long drug effect cycle.

Method used

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  • A kind of preparation method of Shuxiong granule
  • A kind of preparation method of Shuxiong granule

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Effect test

Embodiment 1

[0014] A preparation method of Shuxiong granule, including 100Kg of Panax notoginseng, 100Kg of safflower, and 200 Kg of Rhizoma Chuanxiong. First, the volatile oil of Ligusticum chuanxiong is extracted by alcohol extraction, and 80% ethanol is used as the extraction solvent, and the extraction is performed twice, and the amount of alcohol added is 8 times respectively. , 6 times the amount, and the extraction time is 2 hours and 1.5 hours respectively. The volatile oil is set aside, then the Rhizoma Chuanxiong after extracting the volatile oil is fully mixed with the safflower crushed into fine powder, and alcohol extraction is carried out 3 times with 60%-80% ethanol, and the amount of ethanol added for the first alcohol extraction is 3 -6 times for 2 hours, 2-4 times for the second time, 1.5 hours for 1.5 hours, 2 times for the third time, 1 hour for the time, combine the extracts, recover ethanol, filter to obtain filtrate A and medicinal residues; Add water to the slag an...

Embodiment 2

[0016] A preparation method of Shuxiong Granules, including 300Kg of Panax notoginseng, 200 Kg of safflower, and 400 Kg of Rhizoma Chuanxiong. First, the volatile oil of Ligusticum Chuanxiong is extracted by supercritical fluid extraction, and the medicinal materials of Ligusticum Chuanxiong are crushed to 20-40 meshes, dried, and put into supercritical extraction. In the device, adjust the extraction temperature to 40-60°C, extraction pressure to 15-25Mpa, CO 2 The flow rate is 20-30kg / h, the time is 0.5-2 hours, and the volatile oil is collected for later use. After the volatile oil is extracted, the Ligusticum chuanxiong is fully mixed with the safflower that is crushed into fine powder, and the alcohol extraction is performed 3 times with 60%-80% ethanol The amount of ethanol added for the first time in alcohol extraction is 3-6 times of the drug weight for 2 hours, 2-4 times for the second time for 1.5 hours, 2 times for the third time for 1 hour, combine the extracts, and...

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Abstract

The invention provides a preparation method of new Shuxiong particles, and relates to the field of pharmaceutical technology for traditional Chinese medicines. Volatile oil is extracted from Szechuan lovage rhizomes for standby, and the Szechuan lovage rhizomes whose volatile oil is extracted and safflowers are extracted; after extraction, an obtained extract and notoginseng are mixed for preparing particles; and finally the extracted volatile oil is added into the particles by inclusion technology. The volatile oil is extracted from the Szechuan lovage rhizomes at first, routine preparation steps are used for preparation, and finally the extracted volatile oil is added into the particles; the new Shuxiong particles are used for chest discomfort, chest distress, precordialgia, coronary heart disease, angina pectoris and other symptoms with obvious curative effects and fast effectiveness, and the particles have obvious relaxation effects for aorta ring tension. The particles can obviously improve coronary flow.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, and specifically belongs to a traditional Chinese medicine preparation for stagnation of blood stasis, chest obstruction and heart pain, bruises, swelling and pain due to blood stasis, coronary heart disease, angina pectoris, arrhythmia and soft tissue contusion. Background technique [0002] Studies in recent years have shown that chest-relieving preparations can significantly protect myocardial damage, improve myocardial ischemia, reduce myocardial oxygen consumption, expand coronary arteries, and increase coronary blood flow. In compound Danshen tablets and Xintongding tablets. [0003] At present, the chest-relieving preparations sold on the market are all prepared by first extracting Rhizoma Chuanxiong and Safflower, and then mixing the extracted extract with Radix Notoginseng. However, the preparation method of the medicine has defects such as incomplete extra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/286A61P9/10
CPCA61K9/16A61K36/236A61K36/258A61K36/286A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2300/00
Inventor 胡葵游贵德
Owner JIANGXI JUWANG PHARMA IND
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